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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbkbem1Smoc
endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI:6758512
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ikbkbem1Smoc/Ikbkbem1Smoc C57BL/6J-Ikbkbem1Smoc MGI:6758514


Genotype
MGI:6758514
hm1
Allelic
Composition		 Ikbkbem1Smoc/Ikbkbem1Smoc
Genetic
Background		 C57BL/6J-Ikbkbem1Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbem1Smoc mutation (0 available); any Ikbkb mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:309163 )
N
• mice are fertile

immune system
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:309163 )
• slight decrease in the percentage of regulatory T cells in the thymus and spleen

embryo
embryo phenotype ( J:309163 )
N
• mice born at normal Mendelian ratios

behavior/neurological
behavior/neurological phenotype ( J:309163 )
N
• mice exhibit no behavioral abnormalities

hematopoietic system
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:309163 )
• slight decrease in the percentage of regulatory T cells in the thymus and spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory