138 phenotypes from 12 alleles in 22 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Jag1Gt(betageo)1Byg/Jag1+ involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:146621
Jag1Mhdahtu/Jag1+ C3HeB/FeJ-Jag1Mhdahtu	abnormal cochlear hair cell morphology	J:72108
	abnormal crista ampullaris morphology	J:72108, J:149467
	abnormal organ of Corti morphology	J:72108
	abnormal semicircular canal ampulla morphology	J:72108
	abnormal semicircular canal morphology	J:72108
	decreased cochlear outer hair cell number	J:72108
	head shaking	J:72108
	head tossing	J:86685
	normal hearing/vestibular/ear phenotype	J:72108
	increased cochlear inner hair cell number	J:72108
Jag1Mhdahtu/Jag1Mhdahtu C3HeB/FeJ-Jag1Mhdahtu	abnormal blood vessel morphology	J:72108
	abnormal vitelline vasculature morphology	J:72108
	embryonic growth retardation	J:72108
	embryonic lethality during organogenesis, complete penetrance	J:72108
	enlarged pericardium	J:72108
	hemorrhage	J:72108
	kinked neural tube	J:72108
Jag1Mhdahtu/Jag1Slalom involves: BALB/c * C3H * C3HeB/FeJ	abnormal vitelline vasculature morphology	J:72108
	embryo tissue necrosis	J:72108
	embryonic lethality during organogenesis	J:72108
	hemorrhage	J:72108
Jag1Ndr/Jag1+ involves: C3HeB/FeJ	head bobbing	J:156172
	impaired balance	J:156172
Jag1Ndr/Jag1Ndr involves: C3HeB/FeJ	abnormal neuron differentiation	J:156172
	abnormal vascular development	J:277896
	decreased embryo size	J:277896
	decreased neuronal precursor cell number	J:156172
	embryonic lethality during organogenesis, complete penetrance	J:156172, J:277896
	hemorrhage	J:277896
	increased neuron number	J:156172
	pale yolk sac	J:277896
	pallor	J:277896
Jag1Ndr/Jag1Ndr involves: C3HeB/FeJ * C57BL/6	abnormal bile duct development	J:277897
	abnormal bile duct morphology	J:277897
	abnormal cholangiocyte morphology	J:277897
	abnormal feces composition	J:277897
	abnormal iris morphology	J:277897
	abnormal liver morphology	J:277897
	abnormal liver physiology	J:277897
	abnormal liver vasculature morphology	J:277897
	atrial septal defect	J:277897
	decreased body size	J:277897
	decreased body weight	J:277897
	decreased circulating serum albumin level	J:277897
	increased circulating alkaline phosphatase level	J:277897
	increased circulating aspartate transaminase level	J:277897
	increased circulating bilirubin level	J:277897
	jaundice	J:277897
	lethality throughout fetal growth and development, incomplete penetrance	J:277897
	lethality, incomplete penetrance	J:277897
	microphthalmia	J:277897
	postnatal lethality, incomplete penetrance	J:277897
	premature death	J:277897
	short snout	J:277897
	slow postnatal weight gain	J:277897
	small lens	J:277897
	ventricular septal defect	J:277897
Jag1Ozz/Jag1+ involves: BALB/cOla * C3H	circling	J:82809
	head bobbing	J:83917
	head shaking	J:82809
Jag1Ozz/Jag1Ozz involves: BALB/cOla * C3H	head bobbing	J:83917
Jag1Slalom/Jag1+ involves: BALB/c * C3H	abnormal cochlear sensory epithelium morphology	J:67728
	abnormal semicircular canal ampulla morphology	J:67728
	abnormal semicircular canal morphology	J:67728
	decreased cochlear outer hair cell number	J:67728
	head shaking	J:67728
	increased cochlear inner hair cell number	J:67728
	positive geotaxis	J:67728
Jag1Slalom/Jag1Slalom involves: BALB/c * C3H	abnormal neural tube morphology	J:67728
	abnormal vitelline vasculature morphology	J:67728
	embryonic lethality during organogenesis, complete penetrance	J:67728
Jag1tm1.1Loo/Jag1tm1.1Loo Tg(Alb1-cre)1Khk/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	no abnormal phenotype detected	J:149131
Jag1tm1Frad/Jag1+ Tg(Six2-EGFP/cre)1Amc/0 involves: 129/Sv * C57BL/6 * CD-1	normal renal/urinary system phenotype	J:198632
Jag1tm1Frad/Jag1tm1Frad Tg(Cdh5-cre)7Mlia/0 B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia	abnormal aorta morphology	J:189213
	abnormal cardiac outflow tract development	J:189213
	abnormal coronary vessel morphology	J:189213
	abnormal heart morphology	J:189213
	abnormal heart valve morphology	J:189213
	abnormal pulmonary trunk morphology	J:189213
	calcified aortic valve	J:189213
	dilated heart	J:189213
	heart right ventricle hypertrophy	J:189213
	increased heart right atrium size	J:189213
	increased heart right ventricle size	J:189213
	increased heart right ventricle wall thickness	J:189213
	increased systemic arterial systolic blood pressure	J:189213
	normal liver/biliary system phenotype	J:166890
	normal mortality/aging	J:166890
	overriding aortic valve	J:189213
	pulmonary valve regurgitation	J:189213
	pulmonary valve stenosis	J:189213
	thick heart valve cusps	J:189213
	ventricular septal defect	J:189213
Jag1tm1Frad/Jag1tm1Frad Tg(Mx1-cre)1Cgn/0 involves: 129 * C57BL/6 * CBA	normal hematopoietic system phenotype	J:98129
Jag1tm1Frad/Jag1tm1Frad Tg(Six2-EGFP/cre)1Amc/0 involves: 129/Sv * C57BL/6 * CD-1	decreased nephron number	J:198632
Jag1tm1Frad/Jag1tm1Frad Tg(Tagln-cre)1Her/0 B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her	abnormal bile duct development	J:166890
	abnormal bile duct morphology	J:166890
	abnormal bile secretion	J:166890
	alopecia	J:166890
	cholestasis	J:166890
	decreased body weight	J:166890
	hepatic necrosis	J:166890
	increased circulating alanine transaminase level	J:166890
	increased circulating alkaline phosphatase level	J:166890
	increased circulating aspartate transaminase level	J:166890
	increased circulating bilirubin level	J:166890
	increased circulating cholesterol level	J:166890
	increased circulating gamma-glutamyl transferase level	J:166890
	increased circulating lactate dehydrogenase level	J:166890
	jaundice	J:166890
	lethargy	J:166890
	liver hemorrhage	J:166890
	neonatal lethality, incomplete penetrance	J:166890
	postnatal growth retardation	J:166890
	postnatal lethality, incomplete penetrance	J:166890
Jag1tm1Grid/Jag1+ involves: 129S1/Sv * C57BL/6 * FVB	abnormal eye morphology	J:54907
	abnormal placement of pupils	J:54907
	corneal opacity	J:54907
	iris coloboma	J:54907
	irregularly shaped pupil	J:54907
Jag1tm1Grid/Jag1tm1.1Loo Tg(Alb1-cre)1Khk/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal bile secretion	J:149131
	bile duct proliferation	J:149131
	dilated bile duct	J:149131
Jag1tm1Grid/Jag1tm1Grid involves: 129S1/Sv * C57BL/6 * FVB	abnormal vascular development	J:54907
	abnormal vitelline vascular remodeling	J:54907
	embryonic lethality during organogenesis, complete penetrance	J:54907
	hemorrhage	J:54907
	pale yolk sac	J:54907
Jag1tm1Grid/Jag1tm2Grid Foxg1tm1(cre)Skm/Foxg1+ involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	abnormal cochlea morphology	J:115783
	abnormal cochlear hair cell morphology	J:115783
	abnormal cochlear hair cell number	J:115783
	abnormal cochlear outer hair cell morphology	J:115783
	abnormal crista ampullaris morphology	J:115783
	abnormal lateral semicircular canal morphology	J:115783
	abnormal superior semicircular canal morphology	J:115783
	abnormal utricular macula morphology	J:115783
	abnormal vestibular saccule morphology	J:115783
	absent cochlear hair cells	J:115783
	absent semicircular canals	J:115783
	absent tunnel of Corti	J:115783
	decreased cochlea coiling	J:115783
	normal hearing/vestibular/ear phenotype	J:115783
	perinatal lethality, complete penetrance	J:115783
	small utricle	J:115783
Jag1tm1Grid/Jag1tm2Grid Tg(Tagln-cre)1Her/0 involves: 129S1/Sv * C57BL/6 * SJL	abnormal vascular smooth muscle morphology	J:166769
	cyanosis	J:166769
	patent ductus arteriosus	J:166769
	perinatal lethality, incomplete penetrance	J:166769
	postnatal lethality, complete penetrance	J:166769
	retroesophageal right subclavian artery	J:166769
Jag1tm1Jlew/Jag1tm1Grid Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal angiogenesis	J:157345
	abnormal blood vessel morphology	J:157345
	abnormal retina vasculature morphology	J:157345
	normal cardiovascular system phenotype	J:157345
	decreased angiogenesis	J:157345
	postnatal growth retardation	J:157345
Jag1tm1Jlew/Jag1tm1Jlew involves: C57BL/6J	abnormal cochlear hair cell morphology	J:107414
	abnormal semicircular canal morphology	J:107414
	abnormal utricular macula morphology	J:107414
	absent cochlear outer hair cells	J:107414
	absent vestibular hair cells	J:107414
	increased cochlear inner hair cell number	J:107414
Jag1tm1Jlew/Jag1tm1Jlew Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 involves: C57BL/6 * CBA	decreased angiogenesis	J:157345
Jag1tm1Jlew/Jag1tm1Jlew Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal vascular branching morphogenesis	J:157345
	fetal growth retardation	J:157345
Jag1tm2.1Grid/Jag1tm2.1Grid involves: 129S1/Sv * C57BL/6	abnormal vitelline vascular remodeling	J:115783
	distended pericardium	J:115783
	embryonic lethality during organogenesis, complete penetrance	J:115783
	intracranial hemorrhage	J:115783
Jag1tm2Grid/Jag1tm2Grid H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * C57BL/6 * CBA	abnormal blood vessel morphology	J:181120
	abnormal eating behavior	J:181120
	abnormal palate morphology	J:181120
	abnormal primary palate development	J:181120
	decreased body size	J:181120
	decreased palatal length	J:181120
	malocclusion	J:181120
	midface hypoplasia	J:181120
	premature death	J:181120
	short maxilla	J:181120
Jag1tm2Grid/Jag1tm2Grid Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6	abnormal vascular smooth muscle morphology	J:166769
	abnormal vitelline vascular remodeling	J:166769
	embryonic lethality during organogenesis, complete penetrance	J:166769
	hemorrhage	J:166769
	pericardial edema	J:166769
Jag1Yo/Jag1+ C3HeB/FeJ-Jag1Yo	abnormal posterior semicircular canal morphology	J:82809
	abnormal superior semicircular canal morphology	J:82809
	decreased cochlear outer hair cell number	J:82809
Jag1Yo/Jag1Yo C3HeB/FeJ-Jag1Yo	embryonic lethality during organogenesis, complete penetrance	J:82809