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Jag1Mhdahtu
Chemically induced Allele Detail
Summary
Symbol: Jag1Mhdahtu
Name: jagged 1; Martin Hrabe de Angelis headturner
MGI ID: MGI:2386949
Synonyms: ABE2, Gsfabe2, headturner, Htu, Jag1Htu
Gene: Jag1  Location: Chr2:136923371-136958440 bp, - strand  
Alliance: Jag1Mhdahtu page
Inner ear of Jag1Mhdahtu/Jag1+ mice at E16.5 shows missing or smaller ampullae

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsGenomic sequence analysis of the coding region revealed a G-to-A missense mutation at coding cDNA nucleotide position 866 (c.866G>A) resulting in a nonconservative amino acid substitution of a glycine by an aspartic acid residue at position 289 of the encoded protein (p.G289D). (J:72108)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:  76 strains or lines available
References
Original:  J:72108 Kiernan AE, et al., The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory