Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tnfrsf1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TNFRSF1A
- Mouse genes Tnfrsf1a
- Rat genes Tnfrsf1a
- Zfish genes si:ch211-112c15.8,tnfrsf1a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfrsf1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002020	protease binding	Tnfrsf1a	IPI	RGD:620945	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0002020	protease binding	Tnfrsf1a	IPI	RGD:708542	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P42224	Human	PMID:10848577
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P51397	Human	PMID:1087798
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q9NXR7	Human	PMID:15465831
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546	Human	PMID:16611992
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:16611992
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546	Human	PMID:18022363
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:19641494
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q969G6	Human	PMID:19641494
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546	Human	PMID:19781631
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:19781631
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:20080539
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:20103630
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:22028622
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546	Human	PMID:22817896
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:24070898
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P28799	Human	PMID:24070898
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q13546\|UniProtKB:Q15628	Human	PMID:24130170
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q8TEC5	Human	PMID:24130170
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q9D1X0	Human	PMID:24440909
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:25911380
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:2848815
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:7758105
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:8565075
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q15628	Human	PMID:8943045
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:P78560	Human	PMID:8985253
Molecular Function	GO:0005515	protein binding	TNFRSF1A	IPI	UniProtKB:Q8WXG6	Human	PMID:9115275
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:5512838\|PMID:18022363
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:P01375	Mouse	MGI:MGI:5706670\|PMID:26649818
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:Q05910	Mouse	MGI:MGI:4831059\|PMID:20826683
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:Q31125	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:P27958:PRO_0000037566\|UniProtKB:P39429\|UniProtKB:Q15628	Mouse	MGI:MGI:5616328\|PMID:11374864
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:Q60855\|UniProtKB:Q9EQY0	Mouse	MGI:MGI:5508636\|PMID:16680093
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:3806433\|PMID:18719121
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	PR:O88522	Mouse	PMID:17702576
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	PR:Q8K3K8	Mouse	PMID:17702576
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	PR:Q8CFV9	Mouse	PMID:19641494
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	PR:Q60855	Mouse	PMID:17702576
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	RGD:620888	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	RGD:621313	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0005515	protein binding	Tnfrsf1a	IPI	RGD:628700	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0044877	protein-containing complex binding	Tnfrsf1a	IPI	RGD:621313\|RGD:1560875	Rat	PMID:12786973\|RGD:2298728
Molecular Function	GO:0044877	protein-containing complex binding	Tnfrsf1a	IPI	RGD:621313\|RGD:1310457	Rat	PMID:15590916\|RGD:1624191
Molecular Function	GO:0043120	tumor necrosis factor binding	TNFRSF1A	IPI	UniProtKB:P01375	Human	PMID:9435233
Molecular Function	GO:0043120	tumor necrosis factor binding	Tnfrsf1a	IPI	RGD:3876	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf1a	IPI	UniProtKB:P01374	Mouse	PMID:1645445
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf1a	IPI	UniProtKB:P06804	Mouse	PMID:1645445
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf1a	IMP	MGI:MGI:1861040	Mouse	PMID:11588035
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf1a	IMP		Rat	PMID:20649583\|RGD:5130976
Cellular Component	GO:0030424	axon	Tnfrsf1a	IDA		Rat	PMID:11240015\|RGD:5130963
Cellular Component	GO:0009986	cell surface	Tnfrsf1a	IDA		Mouse	MGI:MGI:5306543\|PMID:21410936
Cellular Component	GO:0009986	cell surface	Tnfrsf1a	IDA		Rat	PMID:20649583\|RGD:5130976
Cellular Component	GO:0005829	cytosol	Tnfrsf1a	IDA		Rat	PMID:21741934\|RGD:8661758
Cellular Component	GO:0005615	extracellular space	TNFRSF1A	IDA		Human	PMID:13130484
Cellular Component	GO:0005615	extracellular space	Tnfrsf1a	IDA		Rat	PMID:20649583\|RGD:5130976
Cellular Component	GO:0000139	Golgi membrane	TNFRSF1A	IDA		Human	PMID:22801493
Cellular Component	GO:0045121	membrane raft	TNFRSF1A	IDA		Human	PMID:17010968
Cellular Component	GO:0045121	membrane raft	Tnfrsf1a	IDA		Mouse	MGI:MGI:3828392\|PMID:17010968
Cellular Component	GO:0045121	membrane raft	Tnfrsf1a	IDA		Rat	PMID:15590916\|RGD:1624191
Cellular Component	GO:0005739	mitochondrion	Tnfrsf1a	IDA		Rat	PMID:21741934\|RGD:8661758
Cellular Component	GO:0005634	nucleus	Tnfrsf1a	IDA		Rat	PMID:11240015\|RGD:5130963
Cellular Component	GO:0032991	protein-containing complex	Tnfrsf1a	IDA		Rat	PMID:15590916\|RGD:1624191
Cellular Component	GO:0032991	protein-containing complex	Tnfrsf1a	IDA		Rat	PMID:20967881\|RGD:5130945
Cellular Component	GO:0043235	receptor complex	TNFRSF1A	IDA		Human	PMID:23382219
Cellular Component	GO:0045202	synapse	Tnfrsf1a	IDA		Rat	PMID:22522145\|RGD:8661759
Biological Process	GO:0003176	aortic valve development	Tnfrsf1a	IGI	UniProtKB:P25119	Mouse	MGI:MGI:6158728\|PMID:26491108
Biological Process	GO:0007166	cell surface receptor signaling pathway	Tnfrsf1a	IMP	MGI:MGI:1857468	Mouse	PMID:9551933
Biological Process	GO:0071392	cellular response to estradiol stimulus	Tnfrsf1a	IEP		Rat	PMID:21252492\|RGD:5130896
Biological Process	GO:0071260	cellular response to mechanical stimulus	TNFRSF1A	IEP		Human	PMID:19593445
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Tnfrsf1a	IMP	MGI:MGI:1861040	Mouse	PMID:11588035
Biological Process	GO:0006952	defense response	Tnfrsf1a	IMP	MGI:MGI:1857261	Mouse	PMID:8387893
Biological Process	GO:0042742	defense response to bacterium	Tnfrsf1a	IMP	MGI:MGI:1857261	Mouse	PMID:9324362
Biological Process	GO:0042742	defense response to bacterium	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-080326-1,ZFIN:ZDB-MRPHLNO-080326-2	Zfish	PMID:18691913
Biological Process	GO:0031101	fin regeneration	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-161223-1	Zfish	PMID:28796253
Biological Process	GO:0006954	inflammatory response	Tnfrsf1a	IMP	MGI:MGI:1857468	Mouse	PMID:9551933
Biological Process	GO:0006954	inflammatory response	Tnfrsf1a	IMP	MGI:MGI:1857468	Mouse	PMID:9843922
Biological Process	GO:0006954	inflammatory response	Tnfrsf1a	IEP		Rat	PMID:14552870\|RGD:737662
Biological Process	GO:0045087	innate immune response	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-080326-1,ZFIN:ZDB-MRPHLNO-080326-2	Zfish	PMID:18691913
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Tnfrsf1a	IMP		Mouse	PMID:17242187
Biological Process	GO:0043066	negative regulation of apoptotic process	Tnfrsf1a	IMP		Rat	PMID:23028454\|RGD:7245942
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	Tnfrsf1a	IGI	UniProtKB:P25119	Mouse	MGI:MGI:6158728\|PMID:26491108
Biological Process	GO:0003332	negative regulation of extracellular matrix constituent secretion	Tnfrsf1a	IGI	UniProtKB:P25119	Mouse	MGI:MGI:6158728\|PMID:26491108
Biological Process	GO:0010629	negative regulation of gene expression	Tnfrsf1a	IDA		Rat	PMID:20501675\|RGD:5130988
Biological Process	GO:0050728	negative regulation of inflammatory response	TNFRSF1A	IMP		Human	PMID:13130484
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tnfrsf1a	IDA		Rat	PMID:20501675\|RGD:5130988
Biological Process	GO:0030593	neutrophil chemotaxis	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-161223-1	Zfish	PMID:27806130
Biological Process	GO:0045766	positive regulation of angiogenesis	Tnfrsf1a	IMP		Rat	PMID:14970118\|RGD:1624195
Biological Process	GO:1902339	positive regulation of apoptotic process involved in morphogenesis	Tnfrsf1a	IGI	UniProtKB:P25119	Mouse	MGI:MGI:6158728\|PMID:26491108
Biological Process	GO:0010628	positive regulation of gene expression	Tnfrsf1a	IMP		Rat	PMID:20700128\|RGD:5130967
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TNFRSF1A	IEP		Human	PMID:12761501
Biological Process	GO:0050729	positive regulation of inflammatory response	Tnfrsf1a	IMP	MGI:MGI:1861040	Mouse	PMID:11588035
Biological Process	GO:0050729	positive regulation of inflammatory response	Tnfrsf1a	IMP	MGI:MGI:1857261,MGI:MGI:2652655	Mouse	PMID:24211183
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Tnfrsf1a	IMP		Rat	PMID:22522145\|RGD:8661759
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Tnfrsf1a	IMP		Rat	PMID:20967881\|RGD:5130945
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TNFRSF1A	IMP		Human	PMID:21410936
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tnfrsf1a	IMP	MGI:MGI:1861040	Mouse	PMID:11588035
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tnfrsf1a	IMP		Rat	PMID:20967881\|RGD:5130945
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	TNFRSF1A	IMP		Human	PMID:21410936
Biological Process	GO:0072659	protein localization to plasma membrane	TNFRSF1A	IMP		Human	PMID:25816133
Biological Process	GO:0003177	pulmonary valve development	Tnfrsf1a	IGI	UniProtKB:P25119	Mouse	MGI:MGI:6158728\|PMID:26491108
Biological Process	GO:0042981	regulation of apoptotic process	Tnfrsf1a	IMP		Rat	PMID:20967881\|RGD:5130945
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	TNFRSF1A	IMP		Human	PMID:25816133
Biological Process	GO:0002631	regulation of granuloma formation	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-161223-1	Zfish	PMID:27806130
Biological Process	GO:0002631	regulation of granuloma formation	tnfrsf1a	IGI	ZFIN:ZDB-GENE-081104-317	Zfish	PMID:27806130
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Tnfrsf1a	IGI	MGI:MGI:1916971,MGI:MGI:1919216	Mouse	PMID:25220458
Biological Process	GO:0043279	response to alkaloid	Tnfrsf1a	IEP		Rat	PMID:20717874\|RGD:5130964
Biological Process	GO:0043200	response to amino acid	Tnfrsf1a	IEP		Rat	PMID:20828607\|RGD:5130959
Biological Process	GO:0009617	response to bacterium	tnfrsf1a	IGI	ZFIN:ZDB-GENE-081104-317	Zfish	PMID:27806130
Biological Process	GO:0009617	response to bacterium	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-161223-1	Zfish	PMID:27806130
Biological Process	GO:0045471	response to ethanol	Tnfrsf1a	IEP		Rat	PMID:15353169\|RGD:1624193
Biological Process	GO:0001666	response to hypoxia	Tnfrsf1a	IEP		Rat	PMID:21404274\|RGD:5130888
Biological Process	GO:0032496	response to lipopolysaccharide	Tnfrsf1a	IEP		Rat	PMID:15509749\|RGD:1624192
Biological Process	GO:0009615	response to virus	tnfrsf1a	IMP	ZFIN:ZDB-MRPHLNO-080326-2	Zfish	PMID:27351838
Biological Process	GO:0009611	response to wounding	Tnfrsf1a	IEP		Rat	PMID:14552870\|RGD:737662
Biological Process	GO:0006366	transcription by RNA polymerase II	Tnfrsf1a	IMP	MGI:MGI:1861040	Mouse	PMID:11588035
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	TNFRSF1A	IMP		Human	PMID:25816133
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Tnfrsf1a	IMP		Rat	PMID:20967881\|RGD:5130945

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.