| GO term: | intrinsic apoptotic signaling pathway in response to DNA damage |
| Synonym: | DNA damage response, signal transduction resulting in induction of apoptosis |
| GO id: | GO:0008630 |
| Definition: | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
| Number of paths to term: | 27 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA damage checkpoint +DNA damage induced protein phosphorylationDNA damage response, detection of DNA damage +DNA repair +histone H3-K56 acetylation in response to DNA damagehistone H4 acetylation involved in response to DNA damage stimulus +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatornegative regulation of response to DNA damage stimulus +positive regulation of response to DNA damage stimulus +regulation of response to DNA damage stimulus +replication fork processing +signal transduction in response to DNA damage +telomere maintenance in response to DNA damage +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA damage checkpoint +DNA damage induced protein phosphorylationDNA damage response, detection of DNA damage +DNA repair +histone H3-K56 acetylation in response to DNA damagehistone H4 acetylation involved in response to DNA damage stimulus +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatornegative regulation of response to DNA damage stimulus +positive regulation of response to DNA damage stimulus +regulation of response to DNA damage stimulus +replication fork processing +signal transduction in response to DNA damage +telomere maintenance in response to DNA damage +biological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimulusresponse to stresscellular response to stressresponse to DNA damage stimulusDNA damage checkpoint +DNA damage induced protein phosphorylationDNA damage response, detection of DNA damage +DNA repair +histone H3-K56 acetylation in response to DNA damagehistone H4 acetylation involved in response to DNA damage stimulus +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatornegative regulation of response to DNA damage stimulus +positive regulation of response to DNA damage stimulus +regulation of response to DNA damage stimulus +replication fork processing +signal transduction in response to DNA damage +telomere maintenance in response to DNA damage +biological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA damage checkpoint +DNA damage induced protein phosphorylationDNA damage response, detection of DNA damage +DNA repair +histone H3-K56 acetylation in response to DNA damagehistone H4 acetylation involved in response to DNA damage stimulus +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatornegative regulation of response to DNA damage stimulus +positive regulation of response to DNA damage stimulus +regulation of response to DNA damage stimulus +replication fork processing +signal transduction in response to DNA damage +telomere maintenance in response to DNA damage +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630] (49 genes, 62 annotations)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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