Tnfrsf1a
Gene Detail

Symbol Name ID

Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a MGI:1314884

STS

D6Mit254

Synonyms

CD120a, p55, p55-R, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNFRI, TNF-R-I, TNFRp55

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr6:125349362-125362484 bp, + strand From VEGA annotation of GRCm38   13123 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor type 1
Gene Tree: Tnfrsf1a

Human homologs

Human Homolog		TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A
NCBI Gene ID		7132
neXtProt AC		NX_P19438
Human Synonyms		CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNFR1-d2, TNFR55, TNF-R55, TNFR60, TNF-R-I
Human Chr (Location)		12p13.2; chr12:6328757-6342117 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human TNFRSF1A

Alleles and phenotypes

All alleles(15) : Gene trapped(3) Targeted(12)
 

Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.

 
Human Diseases Modeled Using Mouse Tnfrsf1a (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	apoptotic process, cell surface receptor signaling pathway, ...
Component	axon, cell surface, ...
Function	protease binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)

Data Summary: Results (64)    Tissues (36)    Images (1)
Theiler Stages: 16, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RT-PCR	64

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) Genomic(15) cDNA(15) Primer pair(7) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023806 (Evidence)
Ensembl Gene Model	ENSMUSG00000030341 (Evidence)
Entrez Gene	21937 (Evidence)
DFCI	TC1572978, TC1601214
DoTS	DT.101378558, DT.535985
NIA Mouse Gene Index	U007419
Consensus CDS Project	CCDS20550.1
International Mouse Knockout Project Status	Tnfrsf1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023806	VEGA Gene Model | MGI Sequence Detail	13123	C57BL/6J
transcript	OTTMUST00000058165	VEGA | MGI Sequence Detail	2156	Not Applicable
polypeptide	OTTMUSP00000028139	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(66) RefSeq(2) UniProt(9)

Polymorphisms

All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(76 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR020419	Tumour necrosis factor receptor 1A
Protein Ontology	PR:000001958	tumor necrosis factor receptor superfamily member 1A

References

(Earliest) J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
(Latest) J:209898 Dong X, et al., Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection. Infect Immun. 2014 May;82(5):1833-9
All references(769)

Other accession IDs

MGD-MRK-15155, MGD-MRK-15156, MGI:98781