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Tnfrsf1a
Gene Detail
Symbol

Name
ID
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884
STS
Synonyms
CD120a, p55, p55-R, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNFRI, TNF-R-I, TNFRp55
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr6:125349362-125362484 bp, + strand
From VEGA annotation of GRCm38

  13123 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNFRSF1A
Protein SuperFamily: tumor necrosis factor receptor type 1
Gene Tree: Tnfrsf1a

Human
homologs
TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7132
neXtProt AC: NX_P19438

Human Synonyms: CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNFR1-d2, TNFR55, TNF-R55, TNFR60, TNF-R-I

Human Chr (Location): 12p13.2; chr12:6328757-6342117 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TNFRSF1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(3) Targeted(15)
 
Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.
 
Human Diseases Modeled in Mice Using Tnfrsf1a (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Tnfrsf1a interacts with 67 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process apoptotic process, cell surface receptor signaling pathway, ...
Component axon, cell surface, ...
Function protease binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (64)    Tissues (40)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 64
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnfrsf1a ; ZFIN tnfrsf1a    NEW 
Molecular
reagents
All nucleic(39) Genomic(15) cDNA(15) Primer pair(7) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023806 (Evidence)
Ensembl Gene Model ENSMUSG00000030341 (Evidence)
Entrez Gene 21937 (Evidence)
DFCI TC1572978, TC1601214
DoTS DT.535985, DT.101378558
NIA Mouse Gene Index U007419
Consensus CDS Project CCDS20550.1
International Mouse Phenotyping Consortium Status Tnfrsf1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023806 VEGA Gene Model | MGI Sequence Detail 13123 C57BL/6J ±  kb
transcript OTTMUST00000058165 VEGA | MGI Sequence Detail 2156 Not Applicable 
polypeptide OTTMUSP00000028139 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(2) UniProt(9)
Polymorphisms
All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020419 Tumour necrosis factor receptor 1A
Protein Ontology PR:000001958 tumor necrosis factor receptor superfamily member 1A
References
(Earliest) J:11097 Lewis M, et al., Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2830-4
(Latest) J:219965 Ehedego H, et al., p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis. Cancer Res. 2015 Mar 15;75(6):1144-55
All references(791)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15155, MGD-MRK-15156, MGI:98781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory