About   Help   FAQ
Gene Detail
tumor necrosis factor receptor superfamily, member 1a
STS D6Mit254
Synonyms CD120a, p55, p55-R, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNFRI, TNF-R-I, TNFRp55
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM

Mapping data(24)
Sequence Map
Chr6:125349362-125362484 bp, + strand
From VEGA annotation of GRCm38

  13123 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor type 1
Gene Tree: Tnfrsf1a

Human Homolog TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A
NCBI Gene ID 7132
neXtProt AC  NX_P19438
Human Synonyms  CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNFR1-d2, TNFR55, TNF-R55, TNFR60, TNF-R-I
Human Chr (Location)  12p13.2; chr12:6328757-6342117 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TNFRSF1A
alleles, and
All mutations/alleles(18) : Gene trapped(3) Targeted(15)
Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.
Human Diseases Modeled Using Mouse Tnfrsf1a (1)    Alleles Annotated to Human Diseases(3)   
Tnfrsf1a interacts with 67 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Gene Ontology
All GO classifications: (61 annotations)
Process apoptotic process, cell surface receptor signaling pathway, ...
Component axon, cell surface, ...
Function protease binding, protein binding, ...
External Resources: FuncBase
Literature Summary: (21 records)
Data Summary: Results (64)    Tissues (40)    Images (1)
Theiler Stages: 16, 18, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(39) Genomic(15) cDNA(15) Primer pair(7) Other(2)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000023806 (Evidence)
Ensembl Gene ModelENSMUSG00000030341 (Evidence)
Entrez Gene21937 (Evidence)
DFCITC1572978, TC1601214
DoTSDT.101378558, DT.535985
NIA Mouse Gene IndexU007419
Consensus CDS ProjectCCDS20550.1
International Mouse Knockout Project StatusTnfrsf1a
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023806 VEGA Gene Model | MGI Sequence Detail 13123 C57BL/6J ±  kb
transcript OTTMUST00000058165 VEGA | MGI Sequence Detail 2156 Not Applicable 
polypeptide OTTMUSP00000028139 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(9)
Polymorphisms All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(76 from dbSNP Build 137)
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020419 Tumour necrosis factor receptor 1A
Protein Ontology PR:000001958 tumor necrosis factor receptor superfamily member 1A
References (Earliest) J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
(Latest) J:212609 Oshima H, et al., TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. Oncogene. 2014 Jul 17;33(29):3820-9
All references(774)
Disease annotation references (1)
accession IDs
MGD-MRK-15155, MGD-MRK-15156, MGI:98781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory