Tnfrsf1a MGI Mouse Gene Detail - MGI:1314884 - tumor necrosis factor receptor superfamily, member 1a

Tnfrsf1a Gene Detail

Symbol

Tnfrsf1a
Name

tumor necrosis factor receptor superfamily, member 1a
Synonyms

CD120a, p55, p55-R, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNFRI, TNF-R-I, TNFRp55

Feature Type

protein coding gene
IDs

MGI:1314884
NCBI Gene: 21937
Gene Overview

MyGene.info: TNFRSF1A

Sequence Map

Chr6:125349362-125362484 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

13123 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.32 cM
Mapping Data

24 experiments
Sequence Tag

D6Mit254

Human Ortholog

TNFRSF1A, TNF receptor superfamily member 1A

Vertebrate Orthologs

10

Human Ortholog

TNFRSF1A, TNF receptor superfamily member 1A
Orthology source: HomoloGene, HGNC
Synonyms

CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNFR1-d2, TNFR55, TNF-R55, TNFR60, TNF-R-I
Links

HGNC:11916

NCBI Gene ID: 7132

neXtProt AC: NX_P19438
Chr Location

12p13.2; chr12:6328757-6342117 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 828
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TNFRSF1A
Protein SuperFamily

tumor necrosis factor receptor type 1
Gene Tree

Tnfrsf1a

Diseases

1 with Tnfrsf1a mouse models; 2 with human TNFRSF1A associations

Human Disease

Mouse Models

Periodic Fever, Familial, Autosomal Dominant OMIM: 142680

View 2 models

Multiple Sclerosis, Susceptibility to, 5; MS5 OMIM: 614810

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

4 with disease annotations

References

3 with disease annotations

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Phenotype Summary

58 phenotypes from 9 alleles in 19 genetic backgrounds
126 phenotypes from multigenic genotypes
1 images
640 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Gene trapped

3
Targeted

16
Transgenic

1

Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.

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All GO Annotations

72
GO References

24

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

64
Tissues

40
cDNA Data

14
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase tnfrsf1a

ZFIN tnfrsf1a

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Tnfrsf1a interacts with 67 markers (Mir29a, Mir29b-1, Mir29b-2, ...) View All

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All Sequences

61
RefSeq

2
UniProt

9
CCDS

CCDS20550.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023806	VEGA Gene Model \| MGI Sequence Detail	13123	C57BL/6J	± kb
transcript	OTTMUST00000058165	VEGA \| MGI Sequence Detail	2156	Not Applicable
polypeptide	OTTMUSP00000028139	VEGA \| MGI Sequence Detail	454	Not Applicable

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SNPs within 2kb

69 from dbSNP Build 142

PCR

2
RFLP

5

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UniProt

9 Sequences
Protein Ontology

PR:000001958 tumor necrosis factor receptor superfamily member 1A
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain

IPR001368 TNFR/NGFR cysteine-rich region

IPR020419 Tumour necrosis factor receptor 1A

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All nucleic 39

Genomic 15

cDNA 15

Primer pair 7

Other 2

Microarray probesets 4

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MGD-MRK-15155, MGD-MRK-15156, MGI:98781

Summaries

All 818

Developmental Gene Expression 22

Diseases 3

Gene Ontology 24

Phenotypes 640
Earliest

J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
Latest

J:233524 Hockendorf U, et al., RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. Cancer Cell. 2016 Jul 11;30(1):75-91

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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