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Tnfrsf1a Gene Detail
Summary
  • Symbol
    Tnfrsf1a
  • Name
    tumor necrosis factor receptor superfamily, member 1a
  • Synonyms
    CD120a, p55, p55-R, TNF-alpha-R1, TNF-alphaR1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNF-R-I, TNFRI, TNFRp55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314884
    NCBI Gene: 21937
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125326686-125339446 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314884
 protein coding gene Chr6:125326325-125339447 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031296
 protein coding gene Chr6:128698509-128711653 (+)
A/J MGP_AJ_G0031267
 protein coding gene Chr6:123838081-123851241 (+)
AKR/J MGP_AKRJ_G0031195
 protein coding gene Chr6:127212912-127226368 (+)
BALB/cJ MGP_BALBcJ_G0031274
 protein coding gene Chr6:123432716-123446076 (+)
C3H/HeJ MGP_C3HHeJ_G0030998
 protein coding gene Chr6:127287812-127302166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031731
 protein coding gene Chr6:132099144-132112306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028880
 protein coding gene Chr6:121047837-121060364 (+)
CAST/EiJ MGP_CASTEiJ_G0030379
 protein coding gene Chr6:127506064-127522182 (+)
CBA/J MGP_CBAJ_G0030959
 protein coding gene Chr6:137142075-137157982 (+)
DBA/2J MGP_DBA2J_G0031115
 protein coding gene Chr6:122764599-122777692 (+)
FVB/NJ MGP_FVBNJ_G0031064
 protein coding gene Chr6:121679745-121693129 (+)
LP/J MGP_LPJ_G0031195
 protein coding gene Chr6:128857270-128871355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031103
 protein coding gene Chr6:141178058-141193062 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031766
 protein coding gene Chr6:127125865-127138987 (+)
PWK/PhJ MGP_PWKPhJ_G0030094
 protein coding gene Chr6:121014536-121027839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029923
 protein coding gene Chr6:125202144-125217116 (+)
WSB/EiJ MGP_WSBEiJ_G0030464
 protein coding gene Chr6:127500608-127514933 (+)



Homology
more
  • Human Ortholog
    TNFRSF1A, TNF receptor superfamily member 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF1A, TNF receptor superfamily member 1A
  • Synonyms
    CD120a, FPF, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNF-R55, TNFR55, TNFR60, TNF-R-I
  • Links
    NCBI Gene ID: 7132
    UniProt: P19438

  • Chr Location
    12p13.31; chr12:6328757-6342114 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfrsf1a mouse models; 9 with human TNFRSF1A associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 11 alleles in 21 genetic backgrounds
    138 phenotypes from multigenic genotypes
    1 images
    904 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    110
  • cDNA Data
    15
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21937 NCBI Gene Model | MGI Sequence Detail 12761 C57BL/6J ±  kb
    transcript NM_011609 RefSeq | MGI Sequence Detail 2186 ZRU/MplStud  
    polypeptide P25118 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 15
      cDNA 18
      Primer pair 12
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15155, MGD-MRK-15156, MGI:98781
    References
    more
    • Summaries
      All 1195
      Developmental Gene Expression 32
      Diseases 3
      Gene Ontology 42
      Phenotypes 904
    • Earliest
      J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
    • Latest
      J:366276 Fei X, et al., Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis. Cell Commun Signal. 2025 Jan 6;23(1):6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory