Tnfrsf1a
Gene Detail

Symbol

Name
ID

Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884

STS

D6Mit254

Synonyms

CD120a, p55, p55-R, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNFRI, TNF-R-I, TNFRp55

Feature Type

protein coding gene

Genetic Map

Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr6:125349362-125362484 bp, + strand From VEGA annotation of GRCm38   13123 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor type 1
Gene Tree: Tnfrsf1a

Human
homologs

Human Homolog		TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A
NCBI Gene ID		7132
neXtProt AC		NX_P19438
Human Synonyms		CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNFAR, TNF-R, TNFR1, TNFR1-d2, TNFR55, TNF-R55, TNFR60, TNF-R-I
Human Chr (Location)		12p13.2; chr12:6328757-6342117 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human TNFRSF1A

Mutations,
alleles, and
phenotypes

All mutations/alleles(18) : Gene trapped(3) Targeted(15)
 

Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.

 
Human Diseases Modeled in Mice Using Tnfrsf1a (1)    Mutations Annotated to Human Diseases (3)   

Interactions

Tnfrsf1a interacts with 67 markers (Mir29a, Mir29b-1, Mir29b-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (62 annotations)

Process	apoptotic process, cell surface receptor signaling pathway, ...
Component	axon, cell surface, ...
Function	protease binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)

Data Summary: Results (64)    Tissues (40)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	64

cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(39) Genomic(15) cDNA(15) Primer pair(7) Other(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000023806 (Evidence)
Ensembl Gene Model	ENSMUSG00000030341 (Evidence)
Entrez Gene	21937 (Evidence)
DFCI	TC1572978, TC1601214
DoTS	DT.101378558, DT.535985
NIA Mouse Gene Index	U007419
Consensus CDS Project	CCDS20550.1
International Mouse Knockout Project Status	Tnfrsf1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023806	VEGA Gene Model | MGI Sequence Detail	13123	C57BL/6J
transcript	OTTMUST00000058165	VEGA | MGI Sequence Detail	2156	Not Applicable
polypeptide	OTTMUSP00000028139	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(74) RefSeq(2) UniProt(17)

Polymorphisms

All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(76 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR020419	Tumour necrosis factor receptor 1A
Protein Ontology	PR:000001958	tumor necrosis factor receptor superfamily member 1A

References

(Earliest) J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
(Latest) J:216496 Afanasyeva MA, et al., Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response. PLoS One. 2014;9(5):e98349
All references(793)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-15155, MGD-MRK-15156, MGI:98781