Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables tumor necrosis factor receptor activity. Involved in several processes, including positive regulation of apoptotic process; regulation of lipid metabolic process; and semi-lunar valve development. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of transcription by RNA polymerase II; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; hemolymphoid system; and respiratory system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
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