Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCL13,CCL2
  • Mouse genes Ccl2
  • Rat genes Ccl2
  • Zfish genes ccl38.6,ccl38a.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031727	CCR2 chemokine receptor binding	Ccl2	IPI	UniProtKB:P51683	Mouse	MGI:MGI:80507|PMID:8662823
Molecular Function	GO:0008009	chemokine activity	CCL13	IDA		Human	PMID:10072545
Molecular Function	GO:0008009	chemokine activity	Ccl2	IDA		Rat	PMID:11104723|RGD:2303114
Molecular Function	GO:0008009	chemokine activity	Ccl2	IDA		Rat	PMID:12953273|RGD:2303089
Molecular Function	GO:0008009	chemokine activity	Ccl2	IDA		Rat	PMID:16127145|RGD:2303093
Molecular Function	GO:0005125	cytokine activity	Ccl2	IDA		Mouse	PMID:23395675
Molecular Function	GO:0001664	G protein-coupled receptor binding	Ccl2	IDA		Mouse	PMID:8631787
Molecular Function	GO:0001664	G protein-coupled receptor binding	Ccl2	IDA		Mouse	PMID:9366570
Molecular Function	GO:0008201	heparin binding	Ccl2	IPI	CHEBI:28304	Rat	PMID:16127145|RGD:2303093
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:Q2F862	Human	PMID:26095031
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P80075	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:O00585	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:O14625	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:P02778	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:P47992	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL13	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	Ccl2	IPI	UniProtKB:E9M5R0	Mouse	MGI:MGI:5926971|PMID:26671708
Molecular Function	GO:0005515	protein binding	Ccl2	IPI	PR:P51675	Mouse	PMID:8631787
Cellular Component	GO:0043679	axon terminus	Ccl2	IDA		Rat	PMID:19059387|RGD:2307005
Cellular Component	GO:0044299	C-fiber	Ccl2	IDA		Rat	PMID:18076762|RGD:4890034
Cellular Component	GO:0005737	cytoplasm	Ccl2	IDA		Rat	PMID:14638441|RGD:1358455
Cellular Component	GO:0030425	dendrite	Ccl2	IDA		Rat	PMID:16025454|RGD:8549734
Cellular Component	GO:0030139	endocytic vesicle	Ccl2	IDA		Rat	PMID:12080327|RGD:8549739
Cellular Component	GO:0005576	extracellular region	CCL2	IDA		Human	PMID:20041150
Cellular Component	GO:0005615	extracellular space	Ccl2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Mouse	PMID:22960654
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Mouse	PMID:23395675
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Mouse	PMID:26432893
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Mouse	PMID:23892723
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Mouse	PMID:19139201
Cellular Component	GO:0005615	extracellular space	Ccl2	IDA		Rat	PMID:19060786|RGD:2307004
Cellular Component	GO:0043025	neuronal cell body	Ccl2	IDA		Rat	PMID:15978006|RGD:1625372
Cellular Component	GO:0043204	perikaryon	Ccl2	IDA		Rat	PMID:16025454|RGD:8549734
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ccl2	IDA		Rat	PMID:14512159|RGD:8548859
Cellular Component	GO:0005791	rough endoplasmic reticulum	Ccl2	IDA		Rat	PMID:12080327|RGD:8549739
Cellular Component	GO:0045202	synapse	Ccl2	IDA		Rat	PMID:23010641|RGD:8548887
Biological Process	GO:0007568	aging	Ccl2	IEP		Rat	PMID:20335145|RGD:4891435
Biological Process	GO:0031100	animal organ regeneration	Ccl2	IEP		Rat	PMID:19420110|RGD:2306994
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	CCL13	IDA		Human	PMID:12949249
Biological Process	GO:0043615	astrocyte cell migration	CCL2	IDA		Human	PMID:12271471
Biological Process	GO:0071318	cellular response to ATP	Ccl2	IEP		Rat	PMID:19125410|RGD:8549571
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Ccl2	IEP		Rat	PMID:14512159|RGD:8548859
Biological Process	GO:0071392	cellular response to estradiol stimulus	Ccl2	IEP		Rat	PMID:17237237|RGD:11526151
Biological Process	GO:0071398	cellular response to fatty acid	Ccl2	IEP		Rat	PMID:14656734|RGD:11526147
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071333	cellular response to glucose stimulus	Ccl2	IEP		Rat	PMID:26222724|RGD:11528562
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	Ccl2	IEP		Rat	PMID:18483405|RGD:8549650
Biological Process	GO:0032869	cellular response to insulin stimulus	Ccl2	IEP		Rat	PMID:17180354|RGD:8549642
Biological Process	GO:0071347	cellular response to interleukin-1	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071347	cellular response to interleukin-1	Ccl2	IDA		Mouse	MGI:MGI:3699670|PMID:14662900
Biological Process	GO:0071347	cellular response to interleukin-1	Ccl2	IEP		Rat	PMID:14512159|RGD:8548859
Biological Process	GO:0071354	cellular response to interleukin-6	Ccl2	IEP		Rat	PMID:8921263|RGD:8549522
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ccl2	IDA		Mouse	MGI:MGI:3699670|PMID:14662900
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ccl2	IEP		Rat	PMID:8921263|RGD:8549522
Biological Process	GO:0071402	cellular response to lipoprotein particle stimulus	Ccl2	IEP		Rat	PMID:11473635|RGD:8549581
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	Ccl2	IEP		Rat	PMID:8921263|RGD:8549522
Biological Process	GO:0071407	cellular response to organic cyclic compound	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Ccl2	IEP		Rat	PMID:7589574|RGD:8549588
Biological Process	GO:0071300	cellular response to retinoic acid	Ccl2	IEP		Rat	PMID:11274229|RGD:8549584
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ccl2	IDA		Mouse	MGI:MGI:3699670|PMID:14662900
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ccl2	IEP		Rat	PMID:14512159|RGD:8548859
Biological Process	GO:0071346	cellular response to type II interferon	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071346	cellular response to type II interferon	Ccl2	IDA		Mouse	MGI:MGI:3699670|PMID:14662900
Biological Process	GO:0071346	cellular response to type II interferon	Ccl2	IEP		Rat	PMID:14512159|RGD:8548859
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ccl2	IEP		Rat	PMID:16331110|RGD:2298662
Biological Process	GO:0070098	chemokine-mediated signaling pathway	Ccl2	IMP		Rat	PMID:18584881|RGD:2303073
Biological Process	GO:0002544	chronic inflammatory response	Ccl2	IEP		Rat	PMID:15104336|RGD:11526143
Biological Process	GO:0019221	cytokine-mediated signaling pathway	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ccl2	IMP		Rat	PMID:16174730|RGD:1625370
Biological Process	GO:0007010	cytoskeleton organization	CCL2	IDA		Human	PMID:10072545
Biological Process	GO:0007010	cytoskeleton organization	CCL13	IDA		Human	PMID:10072545
Biological Process	GO:0048245	eosinophil chemotaxis	CCL13	IDA		Human	PMID:10072545
Biological Process	GO:0008347	glial cell migration	Ccl2	IMP		Rat	PMID:23010641|RGD:8548887
Biological Process	GO:0035684	helper T cell extravasation	Ccl2	IDA		Mouse	MGI:MGI:3812298|PMID:18586982
Biological Process	GO:0006954	inflammatory response	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0006954	inflammatory response	Ccl2	IEP		Rat	PMID:11751160|RGD:625742
Biological Process	GO:0006954	inflammatory response	Ccl2	IEP		Rat	PMID:12144807|RGD:2303104
Biological Process	GO:0006954	inflammatory response	Ccl2	IEP		Rat	PMID:16127145|RGD:2303093
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Ccl2	IDA		Rat	PMID:15978006|RGD:1625372
Biological Process	GO:0031640	killing of cells of another organism	CCL13	IDA		Human	PMID:12949249
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Ccl2	IMP		Rat	PMID:8774140|RGD:8549532
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0048247	lymphocyte chemotaxis	Ccl2	IDA		Rat	PMID:11104723|RGD:2303114
Biological Process	GO:0048246	macrophage chemotaxis	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0048246	macrophage chemotaxis	Ccl2	IDA		Rat	PMID:16127145|RGD:2303093
Biological Process	GO:0060056	mammary gland involution	Ccl2	IEP		Rat	PMID:20110414|RGD:4142798
Biological Process	GO:0000165	MAPK cascade	CCL2	IMP		Human	PMID:21147091
Biological Process	GO:0060135	maternal process involved in female pregnancy	Ccl2	IEP		Rat	PMID:8788206|RGD:8549628
Biological Process	GO:0060137	maternal process involved in parturition	Ccl2	IEP		Rat	PMID:18606702|RGD:2307011
Biological Process	GO:0002548	monocyte chemotaxis	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0016525	negative regulation of angiogenesis	Ccl2	IMP		Mouse	MGI:MGI:3840068|PMID:14566334
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	CCL2	IDA		Human	PMID:12753088
Biological Process	GO:2000502	negative regulation of natural killer cell chemotaxis	CCL2	IDA		Human	PMID:7545673
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CCL2	IDA		Human	PMID:12753088
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0030593	neutrophil chemotaxis	Ccl2	IMP		Rat	PMID:16127145|RGD:2303093
Biological Process	GO:0030316	osteoclast differentiation	Ccl2	HEP		Rat	PMID:16304045|RGD:151665775
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	Ccl2	IDA		Mouse	MGI:MGI:4943793|PMID:20691665
Biological Process	GO:0090280	positive regulation of calcium ion import	CCL2	IDA		Human	PMID:10925302
Biological Process	GO:0045785	positive regulation of cell adhesion	Ccl2	IDA		Rat	PMID:8103296|RGD:8549560
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Ccl2	IDA		Rat	PMID:10225970|RGD:8549768
Biological Process	GO:0002693	positive regulation of cellular extravasation	Ccl2	IDA		Rat	PMID:10225970|RGD:8549768
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Ccl2	IDA		Rat	PMID:8663511|RGD:8549527
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Ccl2	IMP		Rat	PMID:14693680|RGD:1580560
Biological Process	GO:0010628	positive regulation of gene expression	Ccl2	IMP		Mouse	MGI:MGI:6294196|PMID:30687013
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	Ccl2	IMP		Mouse	MGI:MGI:3840068|PMID:14566334
Biological Process	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	Ccl2	IMP		Rat	PMID:8103296|RGD:8549560
Biological Process	GO:0002687	positive regulation of leukocyte migration	Ccl2	IMP		Rat	PMID:14512159|RGD:8548859
Biological Process	GO:0002687	positive regulation of leukocyte migration	Ccl2	IDA		Rat	PMID:7943176|RGD:8549570
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Ccl2	IDA		Mouse	MGI:MGI:3840068|PMID:14566334
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Ccl2	IDA		Rat	PMID:9430491|RGD:8549586
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	Ccl2	IDA		Mouse	MGI:MGI:5634870|PMID:25651887
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	Ccl2	IDA		Rat	PMID:1387671|RGD:8549558
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Ccl2	IMP		Mouse	MGI:MGI:4943659|PMID:19164781
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	Ccl2	IGI	UniProtKB:O55193,UniProtKB:P01581	Rat	PMID:27094552|RGD:14397550
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Ccl2	IDA		Rat	PMID:22222817|RGD:9685053
Biological Process	GO:0050806	positive regulation of synaptic transmission	Ccl2	IDA		Rat	PMID:18584881|RGD:2303073
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Ccl2	IDA		Mouse	MGI:MGI:6275444|PMID:29993042
Biological Process	GO:0050870	positive regulation of T cell activation	Ccl2	IMP		Mouse	MGI:MGI:3699670|PMID:14662900
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccl2	IMP		Rat	PMID:24826069|RGD:8661667
Biological Process	GO:0090303	positive regulation of wound healing	Ccl2	IMP		Rat	PMID:12831234|RGD:11526146
Biological Process	GO:0043491	protein kinase B signaling	CCL2	IMP		Human	PMID:21147091
Biological Process	GO:0008360	regulation of cell shape	CCL2	IDA		Human	PMID:10072545
Biological Process	GO:0008360	regulation of cell shape	CCL13	IDA		Human	PMID:10072545
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	Ccl2	IMP		Mouse	MGI:MGI:3840068|PMID:14566334
Biological Process	GO:0014823	response to activity	Ccl2	IEP		Rat	PMID:18797164|RGD:2307007
Biological Process	GO:0043200	response to amino acid	Ccl2	IEP		Rat	PMID:18475188|RGD:2307016
Biological Process	GO:0046677	response to antibiotic	Ccl2	IEP		Rat	PMID:17304115|RGD:2307141
Biological Process	GO:0009617	response to bacterium	Ccl2	IEP		Mouse	PMID:23012479
Biological Process	GO:1905237	response to cyclosporin A	Ccl2	IEP		Rat	PMID:15059785|RGD:11528531
Biological Process	GO:0045471	response to ethanol	Ccl2	IEP		Rat	PMID:17935147|RGD:2307058
Biological Process	GO:0010332	response to gamma radiation	Ccl2	IEP		Rat	PMID:19084914|RGD:2306303
Biological Process	GO:0051384	response to glucocorticoid	Ccl2	IEP		Rat	PMID:19210118|RGD:2306999
Biological Process	GO:0009408	response to heat	Ccl2	IDA		Rat	PMID:18419759|RGD:2307043
Biological Process	GO:0001666	response to hypoxia	Ccl2	IEP		Rat	PMID:19278353|RGD:2306997
Biological Process	GO:0035900	response to isolation stress	Ccl2	IEP		Rat	PMID:33411841|RGD:152998999
Biological Process	GO:0032496	response to lipopolysaccharide	Ccl2	IEP		Rat	PMID:19111613|RGD:2307002
Biological Process	GO:0009612	response to mechanical stimulus	Ccl2	IEP		Rat	PMID:18606702|RGD:2307011
Biological Process	GO:0032570	response to progesterone	Ccl2	IEP		Rat	PMID:18606702|RGD:2307011
Biological Process	GO:0034612	response to tumor necrosis factor	Ccl2	IEP		Rat	PMID:15855648|RGD:11526154
Biological Process	GO:0033552	response to vitamin B3	Ccl2	IEP		Rat	PMID:19420110|RGD:2306994
Biological Process	GO:0009611	response to wounding	Ccl2	IDA		Mouse	PMID:19404405
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl2	IEP		Rat	PMID:18388116|RGD:2301862
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl2	IEP		Rat	PMID:18413153|RGD:2306987
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl2	IEP		Rat	PMID:19390220|RGD:2306996
Biological Process	GO:0019233	sensory perception of pain	Ccl2	IDA		Mouse	MGI:MGI:6275444|PMID:29993042
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Ccl2	IMP		Rat	PMID:14505427|RGD:1582324
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Ccl2	IMP		Rat	PMID:14693680|RGD:1580560

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern