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Ccl2 Gene Detail
Summary
  • Symbol
    Ccl2
  • Name
    chemokine (C-C motif) ligand 2
  • Synonyms
    HC11, MCAF, MCP1, MCP-1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF
  • Feature Type
    protein coding gene
  • IDs
    MGI:98259
    NCBI Gene: 20296
  • Gene Overview
    MyGene.info: CCL2
Location & Maps
more
  • Sequence Map
    Chr11:82035571-82037453 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1883 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CCL13, C-C motif chemokine ligand 13
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CCL13, C-C motif chemokine ligand 13
    Orthology source: HomoloGene
  • Synonyms
    CKb10, MCP-4, NCC1, NCC-1, SCYA13, SCYL1
  • Links
    NCBI Gene ID: 6357
    neXtProt AC: NX_Q99616

  • Chr Location
    17q11.2; chr17:34356452-34358610 (+)  GRCh38.p2

  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
    Orthology source: HGNC
  • Synonyms
    GDCF-2, HC11, HSMCR30, MCAF, MCP1, MCP-1, SCYA2, SMC-CF
  • Links
    NCBI Gene ID: 6347
    neXtProt AC: NX_P13500

  • Chr Location
    17q11.2-q12; chr17:34255277-34257203 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ccl2 mouse models; 4 with human CCL2 associations

Human Disease Mouse Models
       Macular Degeneration, Age-Related, 2; ARMD2   OMIM: 153800 View 1 model
       Chemokine, Cc Motif, Ligand 2; CCL2   OMIM: 158105
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Neural Tube Defects, Susceptibility To; NTD   OMIM: 182940
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 7 alleles in 18 genetic backgrounds
    35 phenotypes from multigenic genotypes
    5 images
    195 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    2 involving Ccl2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000852 VEGA Gene Model | MGI Sequence Detail 1883 C57BL/6J ±  kb
transcript OTTMUST00000001659 VEGA | MGI Sequence Detail 813 Not Applicable  
polypeptide OTTMUSP00000000786 VEGA | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002122 C-C motif chemokine 2
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 53
    Genomic 8
    cDNA 37
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14333, MGD-MRK-14413, MGI:2144120
References
more
  • Summaries
    All 362
    Developmental Gene Expression 13
    Diseases 3
    Gene Ontology 19
    Phenotypes 195
  • Earliest
    J:7129 Cochran BH, et al., Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul;33(3):939-47
  • Latest
    J:229556 Niemi JP, et al., Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism. Exp Neurol. 2016 Jan;275 Pt 1:25-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory