Ccl2
Gene Detail

Symbol Name ID

Ccl2 chemokine (C-C motif) ligand 2 MGI:98259

Synonyms

HC11, MCAF, MCP1, MCP-1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF

Feature Type

protein coding gene

Genetic Map

Chromosome 11

49.82 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(38)

Sequence Map

Chr11:82035571-82037453 bp, + strand From VEGA annotation of GRCm38   1883 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl2

Human homologs

Human Homolog		CCL13, chemokine (C-C motif) ligand 13
NCBI Gene ID		6357
neXtProt AC		NX_Q99616
Human Synonyms		CKb10, MCP-4, NCC1, NCC-1, SCYA13, SCYL1
Human Chr (Location)		17q11.2; chr17:32683471-32685629 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet.

 
Human Diseases Modeled Using Mouse Ccl2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	angiogenesis, cellular calcium ion homeostasis, ...
Component	cytoplasm, extracellular space, ...
Function	CCR2 chemokine receptor binding, chemokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (171)    Tissues (61)    Images (34)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	171

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(8) cDNA(37) Primer pair(4) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000852 (Evidence)
Ensembl Gene Model	ENSMUSG00000035385 (Evidence)
Entrez Gene	20296 (Evidence)
UniGene	290320
DFCI	TC1580261, TC1580703
DoTS	DT.101401330, DT.99860368
NIA Mouse Gene Index	U013061
Consensus CDS Project	CCDS25139.1
International Mouse Knockout Project Status	Ccl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000852	VEGA Gene Model | MGI Sequence Detail	1883	C57BL/6J
transcript	OTTMUST00000001659	VEGA | MGI Sequence Detail	813	Not Applicable
polypeptide	OTTMUSP00000000786	VEGA | MGI Sequence Detail	148	Not Applicable

All sequences(41) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(11) : PCR(4) RFLP(7) SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000827	CC chemokine, conserved site
InterPro	IPR001811	Chemokine interleukin-8-like domain
Protein Ontology	PR:000002122	C-C motif chemokine 2

References

(Earliest) J:7129 Cochran BH, et al., Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul;33(3):939-47
(Latest) J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
All references(327)

Other accession IDs

MGD-MRK-14333, MGD-MRK-14413, MGI:2144120