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Ccl2
Gene Detail
 Symbol
Name
ID
Ccl2
chemokine (C-C motif) ligand 2
MGI:98259
Synonyms HC11, MCAF, MCP1, MCP-1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF
Feature Type protein coding gene
Genetic Map
Chromosome 11
49.82 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr11:82035571-82037453 bp, + strand
From VEGA annotation of GRCm38

  1883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl2

Human
homologs
Human Homolog CCL13, chemokine (C-C motif) ligand 13
NCBI Gene ID 6357
neXtProt AC  NX_Q99616
Human Synonyms  CKb10, MCP-4, NCC1, NCC-1, SCYA13, SCYL1
Human Chr (Location)  17q11.2; chr17:34356452-34358610 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet.
 
Human Diseases Modeled Using Mouse Ccl2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process angiogenesis, cellular calcium ion homeostasis, ...
Component axon terminus, C-fiber, ...
Function CCR2 chemokine receptor binding, chemokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (171)    Tissues (61)    Images (34)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 171
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(53) Genomic(8) cDNA(37) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000852 (Evidence)
Ensembl Gene ModelENSMUSG00000035385 (Evidence)
Entrez Gene20296 (Evidence)
UniGene290320
DFCITC1580261, TC1580703
DoTSDT.101401330, DT.99860368
NIA Mouse Gene IndexU013061
Consensus CDS ProjectCCDS25139.1
International Mouse Knockout Project StatusCcl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000852 VEGA Gene Model | MGI Sequence Detail 1883 C57BL/6J ±  kb
transcript OTTMUST00000001659 VEGA | MGI Sequence Detail 813 Not Applicable 
polypeptide OTTMUSP00000000786 VEGA | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms All PCR and RFLP(11) : PCR(4) RFLP(7) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002122 C-C motif chemokine 2
References (Earliest) J:7129 Cochran BH, et al., Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul;33(3):939-47
(Latest) J:210252 Ma F, et al., The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol. 2014 Apr 1;192(7):3365-73
All references(344)
Other
accession IDs
MGD-MRK-14333, MGD-MRK-14413, MGI:2144120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory