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Ccl2
Gene Detail
Symbol

Name
ID
Ccl2
chemokine (C-C motif) ligand 2
MGI:98259
Synonyms
HC11, MCAF, MCP1, MCP-1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF
Feature Type
protein coding gene
Genetic Map
Chromosome 11
49.82 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr11:82035571-82037453 bp, + strand
From VEGA annotation of GRCm38

  1883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: CCL13, CCL2
Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl2

Human
homologs
CCL13, chemokine (C-C motif) ligand 13
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6357
neXtProt AC: NX_Q99616

Human Synonyms: CKb10, MCP-4, NCC1, NCC-1, SCYA13, SCYL1

Human Chr (Location): 17q11.2; chr17:34356452-34358610 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(8) Transgenic(1)
Genomic Mutations involving Ccl2 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet.
 
Human Diseases Modeled in Mice Using Ccl2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Ccl2 interacts with 60 markers (Mir17, Mir20b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process angiogenesis, cellular calcium ion homeostasis, ...
Component axon terminus, C-fiber, ...
Function CCR2 chemokine receptor binding, chemokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (171)    Tissues (61)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 171
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(8) cDNA(37) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000852 (Evidence)
Ensembl Gene Model ENSMUSG00000035385 (Evidence)
Entrez Gene 20296 (Evidence)
UniGene 290320
DFCI TC1580261, TC1580703
DoTS DT.101401330, DT.99860368
NIA Mouse Gene Index U013061
Consensus CDS Project CCDS25139.1
International Mouse Phenotyping Consortium Status Ccl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000852 VEGA Gene Model | MGI Sequence Detail 1883 C57BL/6J ±  kb
transcript OTTMUST00000001659 VEGA | MGI Sequence Detail 813 Not Applicable 
polypeptide OTTMUSP00000000786 VEGA | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms
All PCR and RFLP(11) : PCR(4) RFLP(7) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002122 C-C motif chemokine 2
References
(Earliest) J:7129 Cochran BH, et al., Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul;33(3):939-47
(Latest) J:220493 Ousingsawat J, et al., Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nat Commun. 2015;6:6245
All references(354)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14333, MGD-MRK-14413, MGI:2144120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory