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Ccl2 Gene Detail
Summary
  • Symbol
    Ccl2
  • Name
    chemokine (C-C motif) ligand 2
  • Synonyms
    HC11, MCAF, MCP1, MCP-1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF
  • Feature Type
    protein coding gene
  • IDs
    MGI:98259
    NCBI Gene: 20296
  • Gene Overview
    MyGene.info: CCL2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82035577-82037452 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.82 cM, cytoband C-E1
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98259
protein coding gene Chr11:82035571-82037453 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018821
protein coding gene Chr11:83279601-83281489 (+)
A/J MGP_AJ_G0018788
protein coding gene Chr11:80078529-80080407 (+)
AKR/J MGP_AKRJ_G0018758
protein coding gene Chr11:82470435-82472397 (+)
BALB/cJ MGP_BALBcJ_G0018761
protein coding gene Chr11:80472399-80474281 (+)
C3H/HeJ MGP_C3HHeJ_G0018575
protein coding gene Chr11:82522597-82524479 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019213
protein coding gene Chr11:85777797-85779669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016847
protein coding gene Chr11:77049107-77050956 (+)
CAST/EiJ MGP_CASTEiJ_G0018130
protein coding gene Chr11:83072971-83074835 (+)
CBA/J MGP_CBAJ_G0018546
protein coding gene Chr11:89542585-89544464 (+)
DBA/2J MGP_DBA2J_G0018654
protein coding gene Chr11:79639438-79641388 (+)
FVB/NJ MGP_FVBNJ_G0018643
protein coding gene Chr11:79187173-79189050 (+)
LP/J MGP_LPJ_G0018724
protein coding gene Chr11:83803928-83805796 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018670
protein coding gene Chr11:89720513-89722395 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019253
protein coding gene Chr11:82740307-82742185 (+)
PWK/PhJ MGP_PWKPhJ_G0017900
protein coding gene Chr11:80464543-80466469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017691
protein coding gene Chr11:82351209-82353062 (+)
WSB/EiJ MGP_WSBEiJ_G0018182
protein coding gene Chr11:82614379-82616255 (+)



Homology
more
  • Human Ortholog
    CCL13, C-C motif chemokine ligand 13
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CCL13, C-C motif chemokine ligand 13
    Orthology source: HomoloGene
  • Synonyms
    CKb10, MCP-4, NCC1, NCC-1, SCYA13, SCYL1
  • Links
    NCBI Gene ID: 6357
    neXtProt AC: NX_Q99616
    UniProt: Q99616

  • Chr Location
    17q12; chr17:34356452-34358610 (+)  GRCh38.p7

  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
    Orthology source: HGNC
  • Synonyms
    GDCF-2, HC11, HSMCR30, MCAF, MCP1, MCP-1, SCYA2, SMC-CF
  • Links
    NCBI Gene ID: 6347
    neXtProt AC: NX_P13500
    UniProt: P13500

  • Chr Location
    17q12; chr17:34255277-34257203 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ccl2 mouse models; 2 with human CCL2 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 7 alleles in 18 genetic backgrounds
    35 phenotypes from multigenic genotypes
    5 images
    223 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20296 NCBI Gene Model | MGI Sequence Detail 1876 C57BL/6J ±  kb
    transcript NM_011333 RefSeq | MGI Sequence Detail 806 C57BL/6  
    polypeptide P10148 UniProt | EBI | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 8
      cDNA 38
      Primer pair 4
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14333, MGD-MRK-14413, MGI:2144120
    References
    more
    • Summaries
      All 520
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 25
      Phenotypes 223
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265749 Chen G, et al., Sca-1(+) cardiac fibroblasts promote development of heart failure. Eur J Immunol. 2018 Sep;48(9):1522-1538

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory