102 phenotypes from 7 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ccl2tm1.1Pame/Ccl2tm1.1Pame Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: C57BL/6 * DBA	normal immune system phenotype	J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal leukocyte migration	J:171379
	increased susceptibility to bacterial infection	J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6	abnormal leukocyte migration	J:171379
	increased susceptibility to bacterial infection	J:171379
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos involves: 129S1/Sv	abnormal dendritic cell chemotaxis	J:199611
	abnormal dendritic cell physiology	J:199611
	decreased dendritic cell number	J:199611
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos involves: 129S1/Sv * C57BL/6	abnormal chemokine level	J:151874
	abnormal chemokine secretion	J:151874
	abnormal neutrophil physiology	J:151874
	impaired macrophage chemotaxis	J:151874
Ccl2tm1.2Tyos/Ccl2tm1.2Tyos B6N.129S1(FVB)-Ccl2tm1.2Tyos/J	no abnormal phenotype detected	J:137887
Ccl2tm1Lex/Ccl2tm1Lex involves: 129S5/SvEvBrd * C57BL/6	normal impaired macrophage chemotaxis	J:191510
Ccl2tm1Rol/Ccl2tm1Rol (129S4/SvJae x C57BL/6)F1	abnormal response to injury	J:119615
	decreased macrophage cell number	J:119615
Ccl2tm1Rol/Ccl2tm1Rol B6.129S4-Ccl2tm1Rol	abnormal blood circulation	J:118606
	abnormal Bruch membrane morphology	J:147328
	abnormal chemokine level	J:118606, J:151874
	abnormal chemokine secretion	J:151874
	abnormal choriocapillaris morphology	J:147328
	abnormal conditioned taste aversion behavior	J:102583
	abnormal cytokine secretion	J:68145
	abnormal macrophage chemotaxis	J:109290
	abnormal neutrophil physiology	J:151874
	abnormal optic choroid morphology	J:147328
	abnormal response to injury	J:118606
	abnormal retina pigment epithelium morphology	J:147328
	abnormal skeletal muscle morphology	J:118606
	alcohol aversion	J:102583
	alcohol preference	J:102583
	choroidal neovascularization	J:147328
	decreased alcohol consumption	J:102583
	decreased interferon-gamma secretion	J:68145
	decreased leukocyte cell number	J:68145
	decreased macrophage cell number	J:147328
	decreased physiological sensitivity to xenobiotic	J:110695
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:68145
	impaired macrophage chemotaxis	J:68145, J:118606, J:151874
	impaired righting response	J:102583
	impaired skeletal muscle regeneration	J:118606
	increased alcohol consumption	J:102583
	increased CD4-positive, alpha-beta T cell number	J:68145
	increased fluid intake	J:102583
	increased IgG1 level	J:68145
	increased IgG level	J:147328
	increased interleukin-10 secretion	J:68145
	increased muscle weight	J:118606
	increased neutrophil cell number	J:118606
	increased osteoclast cell number	J:109290
	increased susceptibility to age-related retinal degeneration	J:147328
	lipofuscinosis	J:147328
	premature tooth eruption	J:109290
	retina deposits	J:147328
	retina outer nuclear layer degeneration	J:147328
	retina photoreceptor degeneration	J:147328
	skeletal muscle necrosis	J:118606
Ccl2tm1Rol/Ccl2tm1Rol B6.129S4-Ccl2tm1Rol/J	abnormal action potential	J:326871
	abnormal epididymal fat pad morphology	J:110277
	abnormal gluconeogenesis	J:110277
	abnormal glucose homeostasis	J:126512
	abnormal gonadal fat pad morphology	J:126512
	abnormal microglial cell physiology	J:141739
	abnormal neuron physiology	J:326871
	abnormal touch/ nociception	J:326871
	decreased adiponectin level	J:126512
	decreased body weight	J:126512
	decreased circulating free fatty acids level	J:110277
	decreased circulating insulin level	J:110277
	decreased fat cell size	J:110277
	decreased susceptibility to diet-induced hepatic steatosis	J:110277
	decreased susceptibility to neuronal excitotoxicity	J:141739
	impaired glucose tolerance	J:126512
	improved glucose tolerance	J:110277
	increased adiponectin level	J:110277
	increased circulating glucose level	J:126512
	increased circulating insulin level	J:126512
	increased circulating leptin level	J:126512
	increased insulin sensitivity	J:110277
	increased percent body fat/body weight	J:126512
	increased susceptibility to diet-induced obesity	J:126512
	increased total fat pad weight	J:126512
Ccl2tm1Rol/Ccl2tm1Rol involves: 129S4/SvJae	abnormal macrophage physiology	J:155025
	abnormal monocyte morphology	J:121281
	abnormal posture	J:155025
	decreased inflammatory response	J:155025
	decreased lymphocyte cell number	J:147697
	decreased macrophage cell number	J:147697
	decreased physiological sensitivity to xenobiotic	J:147697
	impaired macrophage chemotaxis	J:147697
	increased circulating interferon-gamma level	J:155025
	increased circulating interleukin-10 level	J:155025
	increased circulating tumor necrosis factor level	J:155025
	increased susceptibility to infection induced morbidity/mortality	J:155025
	increased susceptibility to parasitic infection	J:155025
	increased vasodilation	J:155025
Ccl2tm1Rol/Ccl2tm1Rol involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal monocyte morphology	J:45920
	decreased interferon-gamma secretion	J:45920
	decreased interleukin-4 secretion	J:45920
	decreased interleukin-5 secretion	J:45920
	decreased susceptibility to type IV hypersensitivity reaction	J:45920
	impaired macrophage chemotaxis	J:45920
Ccl2tm1Rol/Ccl2tm1Rol involves: 129S4/SvJae * C57BL/6	abnormal heart left ventricle morphology	J:108533
	abnormal macrophage chemotaxis	J:116878
	abnormal physiological neovascularization	J:107646
	abnormal response to cardiac infarction	J:108533
	abnormal T cell physiology	J:116878
	decreased incidence of tumors by chemical induction	J:56068
	decreased interferon-gamma secretion	J:116878
	decreased interleukin-1 beta secretion	J:116878
	decreased interleukin-12b secretion	J:116878
	decreased susceptibility to induced colitis	J:116878
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:116878
	impaired macrophage chemotaxis	J:108533
Ccl2tm1Rol/Ccl2tm1Rol involves: 129S4/SvJae * C57BL/6 * SJL	decreased angiogenesis	J:70862
	delayed wound healing	J:70862
Ccl2tm1Rol/Ccl2tm1Rol SJL.129S4-Ccl2tm1Rol	decreased susceptibility to experimental autoimmune encephalomyelitis	J:68145
Ccl2tm1Rol/Ccl2tm1Rol Tg(Ccr2-GFP)8Pam/0 involves: 129S4/SvJae * C57BL/6J	abnormal leukocyte migration	J:171379
Ccl2tm1Tyos/Ccl2tm1Tyos involves: 129S1/Sv * C57BL/6	abnormal chemokine level	J:151874
	abnormal chemokine secretion	J:151874
Tg(Fabp4-Ccl2)BYt/0 involves: C57BL/6N	abnormal epididymal fat pad morphology	J:110277
	abnormal gluconeogenesis	J:110277
	abnormal glucose homeostasis	J:110277
	impaired glucose tolerance	J:110277
	increased circulating free fatty acids level	J:110277
	increased circulating glucose level	J:110277
	increased liver triglyceride level	J:110277
	insulin resistance	J:110277