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Gene Ontology Browser
Term Detail
GO term:vascular endothelial growth factor receptor signaling pathway
Synonym: VEGF receptor signaling pathway
Synonym: VEGF receptor signalling pathway
Synonym: VEGFR signaling pathway
GO id:GO:0048010
Definition:Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
CommentsIn GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                                negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                                positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                                is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                                is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                        is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                                negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                                positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                                is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                                is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                        is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                        negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                        positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                        regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                        is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                        is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                is-avascular endothelial growth factor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway [GO:0048010] (44 genes, 66 annotations)
                                                                                negatively-regulatesnegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                is-apositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
                                                                                positively-regulatespositive regulation of vascular endothelial growth factor receptor signaling pathway
                                                                                regulatesregulation of vascular endothelial growth factor receptor signaling pathway +
                                                                                is-avascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
                                                                                is-avascular endothelial growth factor receptor-1 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-2 signaling pathway
                                                                                is-avascular endothelial growth factor receptor-3 signaling pathway
                                                                        is-avascular endothelial growth factor signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory