| GO term: | vascular endothelial growth factor receptor signaling pathway |
| Synonym: | VEGF receptor signaling pathway |
| Synonym: | VEGF receptor signalling pathway |
| Synonym: | VEGFR signaling pathway |
| GO id: | GO:0048010 |
| Definition: | Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
| Comments | In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayenzyme linked receptor protein signaling pathwaytransmembrane receptor protein tyrosine kinase signaling pathwayactivation of transmembrane receptor protein tyrosine kinase activitybrain-derived neurotrophic factor receptor signaling pathway +collagen-activated tyrosine kinase receptor signaling pathwayephrin receptor signaling pathway +ERBB signaling pathway +fibroblast growth factor receptor signaling pathway +glial cell-derived neurotrophic factor receptor signaling pathway +growth hormone receptor signaling pathway +hepatocyte growth factor receptor signaling pathwayinsulin receptor signaling pathway +insulin-like growth factor receptor signaling pathway +Kit signaling pathway +neurotrophin TRK receptor signaling pathway +platelet-derived growth factor receptor signaling pathway +sevenless signaling pathway +Tie signaling pathwaytorso signaling pathwayvascular endothelial growth factor receptor signaling pathway [GO:0048010] (43 genes, 64 annotations)negative regulation of vascular endothelial growth factor receptor signaling pathwaypositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwaypositive regulation of vascular endothelial growth factor receptor signaling pathwayregulation of vascular endothelial growth factor receptor signaling pathway +vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitmentvascular endothelial growth factor receptor-1 signaling pathwayvascular endothelial growth factor receptor-2 signaling pathwayvascular endothelial growth factor receptor-3 signaling pathwayvascular endothelial growth factor signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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