| GO term: | osteoclast differentiation |
| Synonym: | osteoclast cell differentiation |
| GO id: | GO:0030316 |
| Definition: | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
| Number of paths to term: | 30 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationmyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processcellular developmental processcell differentiationmyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationmyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesismyeloid cell differentiationmyeloid leukocyte differentiationgranulocyte differentiation +macrophage differentiation +mast cell differentiation +monocyte differentiation +myeloid dendritic cell differentiation +negative regulation of myeloid leukocyte differentiation +osteoclast differentiation [GO:0030316] (65 genes, 94 annotations)multinuclear osteoclast differentiation +negative regulation of osteoclast differentiationosteoclast development +positive regulation of osteoclast differentiationregulation of osteoclast differentiation +positive regulation of myeloid leukocyte differentiation +regulation of myeloid leukocyte differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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