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Gene Ontology Browser
Term Detail
GO term:chemokine activity
GO id:GO:0008009
Definition:The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
CommentsSee also the molecular function term 'cytokine activity ; GO:0005125'.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aprotein binding
                                is-areceptor binding
                                        is-acytokine activity
                                                is-achemokine activity [GO:0008009] (38 genes, 45 annotations)


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aprotein binding
                                is-areceptor binding
                                        is-acytokine receptor binding
                                                is-achemokine receptor binding
                                                        is-aCCR chemokine receptor binding +
                                                        is-achemokine activity [GO:0008009] (38 genes, 45 annotations)
                                                        is-aCXCR chemokine receptor binding +
                                                        is-aXCR1 chemokine receptor binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aprotein binding
                                is-areceptor binding
                                        is-aG-protein coupled receptor binding
                                                is-achemokine receptor binding
                                                        is-aCCR chemokine receptor binding +
                                                        is-achemokine activity [GO:0008009] (38 genes, 45 annotations)
                                                        is-aCXCR chemokine receptor binding +
                                                        is-aXCR1 chemokine receptor binding


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory