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All mouse models of high grade glioma with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
 | glioblastoma |
\Nf1tm1Fcr/\Nf1tm1Fcr \Trp53tm1Elee/\Trp53tm1Elee \Tg(GFAP-cre)25Mes/0 |
involves: 129S/SvEv * 129S4/SvJae * FVB/N | J:149662 | View | |||
| glioblastoma |
\Trp53tm1Elee/\Trp53tm1Tyj \Tg(GFAP-cre)25Mes/0 |
involves: 129S2/SvPas * 129S4/SvJae * FVB/N | J:149662 | View | ||||
| high grade glioma | \Tg(GFAP-Hras1)2Agu/\Tg(GFAP-Hras1)2Agu | involves: 129S1/Sv * 129X1/SvJ * ICR | J:69129 | View | ||||
| malignant astrocytoma | \Tg(GFAP-Hras1)2Agu/\Tg(GFAP-Hras1)2Agu | involves: 129S1/Sv * 129X1/SvJ * ICR | J:69129 | View | ||||
 | high grade glioma |
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp \Col1a1tm1(CAG-EGFR)Char/\Col1a1tm1(CAG-EGFR)Char \Ptentm1Hwu/\Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | |||
| high grade glioma |
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp \Col1a1tm1(CAG-EGFR)Char/\Col1a1tm2(CAG-EGFR*)Char \Ptentm1Hwu/\Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | ||||
| high grade glioma |
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp \Col1a1tm2(CAG-EGFR*)Char/\Col1a1tm2(CAG-EGFR*)Char \Ptentm1Hwu/\Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | ||||
| high grade glioma |
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sortm1Sor \Ptentm1Mro/\Ptentm1Mro \Slc1a3tm1(cre/ERT2)Mgoe/\Slc1a3+ \Trp53tm1Brn/\Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor | J:229481 | View | ||||
| high grade glioma |
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sortm1Sor \Ptentm1Mro/\Ptentm1Mro \Trp53tm1Brn/\Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJaeSor | J:229481 | View | ||||
| high grade glioma |
\Tg(S100b-v-erbB)4496Waw/0 \Trp53tm1Brd/\Trp53tm1Brd |
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J | J:137800 | View | ||||
| Transgenes and Other Mutations | malignant astrocytoma |
\Ptentm2.1Ppp/\Ptentm2.1Ppp \Tg(GFAP-TAg121)1Tvd/0 |
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N | J:99385 | View | |||
| malignant astrocytoma | \Tg(GFAP-SRC)1Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | \Tg(GFAP-SRC)2Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | \Tg(GFAP-TAg121)1Tvd/0 | involves: C57BL/6 * DBA/2 * FVB/N | J:77132 | View | ||||
| oligodendroglioma |
\Cdkn2atm1Rdp/\Cdkn2a+ \Tg(S100b-v-erbB)4496Waw/0 |
involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL | J:82649 | View | ||||
| oligodendroglioma |
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp \Tg(S100b-v-erbB)4496Waw/0 |
involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL | J:82649 | View | ||||
| oligodendroglioma | \Tg(S100b-v-erbB)4496Waw/0 | involves: C57BL/6J * DBA/2J * FVB/N | J:82649 | View | ||||
| oligodendroglioma |
\Tg(S100b-v-erbB)4496Waw/0 \Trp53tm1Brd/\Trp53+ |
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N | J:82649 | View | ||||
| Additional Complex Models | glioblastoma proneural subtype |
\Gt(ROSA)26Sortm2Thl/\Gt(ROSA)26Sor+ \Ptentm1Hwu/\Ptentm1Hwu \Trp53tm1Thl/\Trp53tm1Thl \Tyrc-Brd/\Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | |||
| glioblastoma proneural subtype |
\Gt(ROSA)26Sortm2Thl/\Gt(ROSA)26Sor+ \Ptentm1Hwu/\Ptentm1Hwu \Tyrc-Brd/\Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | ||||
| malignant astrocytoma |
\Nf1tm1Par/\Nf1+ \Ptentm1Hwu/\Pten+ \Trp53tm1Tyj/\Trp53+ \Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
\Nf1tm1Par/\Nf1+ \Trp53tm1Elee/\Trp53+ \Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
\Nf1tm1Par/\Nf1+ \Trp53tm1Tyj/\Trp53+ \Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
\Nf1tm1Tyj/\Nf1+ \Trp53tm1Tyj/\Trp53+ |
(C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
\Nf1tm1Tyj/\Nf1+ \Trp53tm1Tyj/\Trp53+ |
(CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
\Nf1tm1Tyj/\Nf1+ \Trp53tm1Tyj/\Trp53+ |
(CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
\Nf1tm1Tyj/\Nf1+ \Trp53tm1Tyj/\Trp53+ |
(SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
\Nf1tm1Tyj/\Nf1+ \Trp53tm1Tyj/\Trp53+ |
B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ + | J:64364 | View | ||||
| oligodendroglioma |
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp \Tg(NES-TVA)J12Ech/0 |
involves: 129/Sv * C57BL/6 * FVB/N * SJL | J:153220 | View | ||||