Cd19tm1(cre)Cgn/Cd19+
Notch2tm1.1Hhi/Notch2+
involves: 129P2/OlaHsd * C57BL/6 * CBA
|
decreased marginal zone B cell number |
J:83476
|
Cd19tm1(cre)Cgn/Cd19+
Notch2tm2Hhi/Notch2tm1.1Hhi
involves: 129P2/OlaHsd * C57BL/6 * CBA
|
abnormal spleen marginal zone morphology |
J:83476
|
|
absent marginal zone B cells |
J:83476
|
|
decreased transitional stage B cell number |
J:83476
|
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
|
abnormal B cell differentiation |
J:179036
|
|
abnormal marginal zone B cell physiology |
J:179036
|
|
abnormal spleen marginal zone morphology |
J:179036
|
|
decreased B cell number |
J:179036
|
|
decreased B-1a cell number |
J:179036
|
|
decreased B-2 B cell number |
J:179036
|
|
decreased follicular B cell number |
J:179036
|
|
decreased IgG1 level |
J:179036
|
|
decreased IgG3 level |
J:179036
|
|
decreased IgM level |
J:179036
|
|
decreased spleen B cell follicle size |
J:179036
|
|
decreased spleen germinal center number |
J:179036
|
|
decreased transitional stage T2 B cell number |
J:179036
|
|
increased B cell proliferation |
J:179036
|
|
increased marginal zone B cell number |
J:179036
|
|
increased spleen weight |
J:179036
|
|
increased T cell number |
J:179036
|
|
increased transitional stage T1 B cell number |
J:179036
|
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
|
abnormal B cell differentiation |
J:179036
|
|
abnormal spleen marginal zone morphology |
J:179036
|
|
decreased follicular B cell number |
J:179036
|
|
decreased mature B cell number |
J:179036
|
|
decreased pre-B cell number |
J:179036
|
|
decreased transitional stage T2 B cell number |
J:179036
|
|
increased marginal zone B cell number |
J:179036
|
|
increased transitional stage T1 B cell number |
J:179036
|
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
involves: 129S6/SvEvTac * BALB/c * C57BL/6J
|
arrested B cell differentiation |
J:179036
|
|
decreased B cell number |
J:179036
|
|
decreased splenocyte number |
J:179036
|
|
increased bone marrow cell number |
J:179036
|
|
increased T cell number |
J:179036
|
Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
|
abnormal kidney development |
J:185844
|
|
abnormal metanephric ureteric bud development |
J:185844
|
|
abnormal nephrogenic zone morphology |
J:185844
|
|
absent metanephric mesenchyme |
J:185844
|
|
dilated proximal convoluted tubule |
J:185844
|
|
dilated renal tubule |
J:185844
|
|
impaired branching involved in ureteric bud morphogenesis |
J:185844
|
|
neonatal lethality, complete penetrance |
J:185844
|
|
renal glomerulus cyst |
J:185844
|
|
small kidney |
J:185844
|
Notch2Gt(AG0498)Wtsi/Notch2+
involves: 129P2/OlaHsd * C57BL/6
|
no abnormal phenotype detected |
J:132939
|
Notch2Gt(betageo)1Byg/Notch2+
B6.129P2-Notch2Gt(betageo)1Byg
|
decreased marginal zone B cell number |
J:146621
|
Notch2tm1.1(cre/ERT2)Sat/Notch2+
C57BL/6-Notch2tm1.1(cre/ERT2)Sat
|
no abnormal phenotype detected |
J:179632
|
Notch2tm1.1(cre/ERT2)Sat/Notch2tm1.1(cre/ERT2)Sat
C57BL/6-Notch2tm1.1(cre/ERT2)Sat
|
embryonic lethality |
J:179632
|
Notch2tm1.1Ecan/Notch2+
involves: 129 * 129S1/Sv * C57BL/6J
|
abnormal compact bone morphology |
J:230045
|
|
abnormal osteoclast differentiation |
J:230045
|
|
abnormal osteoclast morphology |
J:230045
|
|
decreased body weight |
J:230045
|
|
decreased bone mineral density |
J:230045
|
|
decreased bone trabecula number |
J:230045
|
|
decreased bone volume |
J:230045
|
|
decreased compact bone area |
J:230045
|
|
decreased compact bone thickness |
J:230045
|
|
decreased trabecular bone connectivity density |
J:230045
|
|
decreased trabecular bone thickness |
J:230045
|
|
decreased trabecular bone volume |
J:230045
|
|
increased bone mineralization |
J:230045
|
|
increased bone resorption |
J:230045
|
|
increased osteoblast cell number |
J:230045
|
|
increased osteoclast cell number |
J:230045
|
|
short femur |
J:230045
|
Notch2tm1.1Ecan/Notch2tm1.1Ecan
involves: 129 * 129S1/Sv * C57BL/6J
|
perinatal lethality, complete penetrance |
J:230045
|
Notch2tm1.1Hhi/Notch2tm1.1Hhi
Tg(Cd8a-cre)1Itan/0
involves: C57BL/6 * CBA
|
abnormal CD8-positive, alpha-beta T cell physiology |
J:141009
|
|
abnormal cytotoxic T cell physiology |
J:141009
|
|
increased susceptibility to parasitic infection |
J:141009
|
Notch2tm1.1Hhtg/Notch2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
abnormal body composition |
J:311038
|
|
abnormal interleukin level |
J:311038
|
|
abnormal osteoclast differentiation |
J:311038
|
|
abnormal skeleton morphology |
J:311038
|
|
decreased bone mineral density |
J:311038
|
|
decreased bone trabecula number |
J:311038
|
|
decreased diameter of femur |
J:311038
|
|
decreased femur compact bone thickness |
J:311038
|
|
decreased trabecular bone thickness |
J:311038
|
|
decreased trabecular bone volume |
J:311038
|
|
increased bone ossification |
J:311038
|
|
increased bone resorption |
J:311038
|
|
increased circulating interleukin-6 level |
J:311038
|
|
increased circulating type I collagen C-terminal telopeptide level |
J:311038
|
|
increased interleukin-6 secretion |
J:311038
|
|
increased osteoblast cell number |
J:311038
|
|
increased osteoclast cell number |
J:311038
|
|
normal
renal/urinary system phenotype |
J:311038
|
|
short femur |
J:311038
|
|
short tibia |
J:311038
|
|
short vertebral body |
J:311038
|
Notch2tm1.1Hhtg/Notch2tm1.1Hhtg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
abnormal vertebral body morphology |
J:311038
|
|
decreased bone mineral density of femur |
J:311038
|
|
premature death |
J:311038
|
Notch2tm1Frad/Notch2+
Tg(Tyr-cre)2Lru/0
involves: 129/Sv * BALB/c * C57BL/6 * DBA/2
|
normal
pigmentation phenotype |
J:116658
|
Notch2tm1Frad/Notch2tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: BALB/c * C57BL/6 * CBA
|
abnormal B cell differentiation |
J:125373
|
|
absent marginal zone B cells |
J:125373
|
|
normal
hematopoietic system phenotype |
J:125373
|
Notch2tm1Frad/Notch2tm1Frad
Tg(Tyr-cre)2Lru/0
involves: 129/Sv * BALB/c * C57BL/6 * DBA/2
|
diluted coat color |
J:116658
|
Notch2tm1Grid/Notch2tm1Grid
involves: 129S1/Sv * C57BL/6J
|
abnormal bile duct development |
J:74574
|
|
abnormal eye morphology |
J:67157
|
|
abnormal glomerular capillary endothelium morphology |
J:67157
|
|
abnormal hyaloid artery morphology |
J:67157
|
|
abnormal kidney cortex morphology |
J:67157
|
|
abnormal myocardial trabeculae morphology |
J:67157
|
|
abnormal podocyte morphology |
J:67157
|
|
abnormal renal glomerulus morphology |
J:67157
|
|
abnormal ureteric bud morphology |
J:67157
|
|
absent mesangial cell |
J:67157
|
|
decreased kidney cell proliferation |
J:67157
|
|
embryonic growth retardation |
J:67157
|
|
heart hypoplasia |
J:67157
|
|
hemorrhage |
J:67157
|
|
impaired branching involved in ureteric bud morphogenesis |
J:67157
|
|
increased kidney apoptosis |
J:67157
|
|
kidney microaneurysm |
J:67157
|
|
microphthalmia |
J:67157
|
|
neonatal lethality, incomplete penetrance |
J:67157
|
|
pericardial effusion |
J:67157
|
|
persistent hyperplastic primary vitreous |
J:67157
|
|
prenatal lethality, incomplete penetrance |
J:67157
|
|
renal hypoplasia |
J:67157
|
|
skin edema |
J:67157
|
|
small kidney |
J:67157
|
Notch2tm1Rko/Notch2tm1Rko
Tg(Msx2-cre)5Rem/0
Not Specified
|
no abnormal phenotype detected |
J:94517
|
Notch2tm1Yha/Notch2+
B6.129-Notch2tm1Yha
|
abnormal spleen marginal zone morphology |
J:85379
|
|
decreased B-1 B cell number |
J:85379
|
|
decreased marginal zone B cell number |
J:85379
|
Notch2tm1Yha/Notch2tm1Yha
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
abnormal chorionic plate morphology |
J:120082
|
|
abnormal placenta labyrinth morphology |
J:120082
|
|
abnormal placenta morphology |
J:120082
|
|
abnormal placenta size |
J:120082
|
|
abnormal placenta vasculature |
J:120082
|
|
embryonic growth retardation |
J:55841,
J:120082
|
|
embryonic lethality during organogenesis, complete penetrance |
J:55841,
J:120082
|
|
increased embryonic tissue cell apoptosis |
J:55841
|
Notch2tm2.1Ecan/Notch2tm2.1Ecan
involves: C57BL/6J
|
normal
skeleton phenotype |
J:246017
|
Notch2tm2.1Ecan/Notch2tm2.1Ecan
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J
|
normal
skeleton phenotype |
J:246017
|
Notch2tm2.1Ecan/Notch2tm2.1Ecan
Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
involves: 129P2/OlaHsd * C57BL/6J
|
normal
skeleton phenotype |
J:246017
|
Notch2tm2.1Ecan/Notch2tm2.1Ecan
Tg(BGLAP-cre)1Clem/0
involves: C57BL/6J * FVB/NJ
|
abnormal bone trabecula morphology |
J:246017
|
|
abnormal compact bone morphology |
J:246017
|
|
abnormal femur morphology |
J:246017
|
|
abnormal trabecular bone morphology |
J:246017
|
|
decreased bone mineral density |
J:246017
|
|
decreased bone mineralization |
J:246017
|
|
decreased bone trabecula number |
J:246017
|
|
decreased compact bone area |
J:246017
|
|
decreased compact bone thickness |
J:246017
|
|
decreased compact bone volume |
J:246017
|
|
decreased trabecular bone connectivity density |
J:246017
|
|
decreased trabecular bone thickness |
J:246017
|
|
decreased trabecular bone volume |
J:246017
|
|
increased bone trabecular spacing |
J:246017
|
|
increased osteoclast cell number |
J:246017
|
Notch2tm2.2Ecan/Notch2+
involves: 129S1/Sv * C57BL/6J
|
abnormal bone trabecula morphology |
J:246017
|
|
abnormal compact bone morphology |
J:246017
|
|
abnormal femur morphology |
J:246017
|
|
abnormal trabecular bone morphology |
J:246017
|
|
decreased bone mineral density |
J:246017
|
|
decreased bone trabecula number |
J:246017
|
|
decreased compact bone thickness |
J:246017
|
|
decreased compact bone volume |
J:246017
|
|
decreased trabecular bone connectivity density |
J:246017
|
|
decreased trabecular bone thickness |
J:246017
|
|
decreased trabecular bone volume |
J:246017
|
|
increased bone trabecular spacing |
J:246017
|
|
short femur |
J:246017
|
Notch2tm2Grid/Notch2tm2Grid
involves: 129S1/Sv * C57BL/6J
|
abnormal cardiovascular system physiology |
J:105278
|
|
embryonic growth retardation |
J:105278
|
|
embryonic lethality during organogenesis, complete penetrance |
J:105278
|
|
pericardial edema |
J:105278
|
Notch2tm2Grid/Notch2tm3Grid
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * C57BL/6 * DBA
|
abnormal bile duct morphology |
J:133171
|
|
decreased body size |
J:133171
|
|
decreased body weight |
J:133171
|
|
focal hepatic necrosis |
J:133171
|
|
normal
homeostasis/metabolism phenotype |
J:133171
|
|
increased circulating alanine transaminase level |
J:133171
|
|
increased circulating alkaline phosphatase level |
J:133171
|
|
increased circulating bilirubin level |
J:133171
|
Notch2tm2Hhi/Notch2tm1.1Hhi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA
|
decreased marginal zone B cell number |
J:83476
|
|
normal
immune system phenotype |
J:83476
|
Notch2tm2Hhi/Notch2tm2Hhi
involves: C57BL/6 * CBA
|
embryonic lethality during organogenesis, complete penetrance |
J:83476
|
Notch2tm3.1Grid/Notch2tm3.1Grid
involves: 129S1/Sv * C57BL/6J
|
abnormal cardiovascular system physiology |
J:105278
|
|
embryonic growth retardation |
J:105278
|
|
embryonic lethality during organogenesis, complete penetrance |
J:105278
|
|
pericardial edema |
J:105278
|
Notch2tm3Grid/Notch2tm3.1Grid
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6
|
abnormal tooth morphology |
J:132939
|
|
abnormal vascular smooth muscle morphology |
J:132939
|
|
aorta stenosis |
J:132939
|
|
cyanosis |
J:132939
|
|
decreased body weight |
J:132939
|
|
postnatal lethality, incomplete penetrance |
J:132939
|
|
pulmonary artery stenosis |
J:132939
|
|
supravalvar pulmonary trunk stenosis |
J:132939
|
Notch2tm3Grid/Notch2tm3.1Grid
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * C57BL/6 * DBA
|
abnormal bile duct morphology |
J:133171
|
|
decreased body size |
J:133171
|
|
decreased body weight |
J:133171
|
|
focal hepatic necrosis |
J:133171
|
|
normal
homeostasis/metabolism phenotype |
J:133171
|
|
increased circulating alanine transaminase level |
J:133171
|
|
increased circulating alkaline phosphatase level |
J:133171
|
|
increased circulating bilirubin level |
J:133171
|
Notch2tm3Grid/Notch2tm3.1Grid
Tg(Tagln-cre)1Her/?
involves: 129 * C57BL/6
|
abnormal blood flow velocity |
J:132939
|
|
aorta stenosis |
J:132939
|
|
cyanosis |
J:132939
|
|
postnatal lethality, incomplete penetrance |
J:132939
|
|
pulmonary artery stenosis |
J:132939
|
Notch2tm3Grid/Notch2tm3Grid
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
abnormal nervous system physiology |
J:130929
|
|
abnormal olfactory epithelium morphology |
J:130929
|
|
abnormal sensory neuron morphology |
J:130929
|
|
decreased body weight |
J:130929
|
|
increased apoptosis |
J:130929
|
|
increased neuron apoptosis |
J:130929
|
|
increased neuronal precursor cell number |
J:130929
|
|
neuron degeneration |
J:130929
|
|
premature death |
J:130929
|
|
small pituitary gland |
J:130929
|
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv
|
abnormal cell cycle |
J:119907
|
|
abnormal kidney collecting duct morphology |
J:119907
|
|
abnormal kidney development |
J:119907
|
|
abnormal kidney papilla morphology |
J:119907
|
|
abnormal kidney pelvis morphology |
J:119907
|
|
abnormal kidney vasculature morphology |
J:119907
|
|
abnormal proximal convoluted tubule morphology |
J:119907
|
|
abnormal renal glomerulus morphology |
J:119907
|
|
abnormal renal tubule morphology |
J:119907
|
|
abnormal urinary bladder morphology |
J:119907
|
|
absent podocytes |
J:119907
|
|
normal
cellular phenotype |
J:119907
|
|
embryonic lethality during organogenesis, complete penetrance |
J:119907
|
|
kidney failure |
J:119907
|
|
kidney hemorrhage |
J:119907
|
|
renal hypoplasia |
J:119907
|
|
small kidney |
J:119907
|
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * C57BL/6 * SJL
|
neonatal lethality, complete penetrance |
J:198632
|
|
renal hypoplasia |
J:198632
|
Notch2tm3Grid/Notch2tm3Grid
Tg(Tpbpa-cre,-EGFP)5Jcc/0
involves: 129S1/Sv
|
abnormal ovary morphology |
J:173527
|
|
abnormal placenta vasculature |
J:173527
|
|
abnormal pregnancy |
J:173527
|
|
ovarian follicular cyst |
J:173527
|
|
ovary hemorrhage |
J:173527
|
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