Gt(ROSA)26Sortm2(Notch2)Ryn
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2(Notch2)Ryn |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ryuichi Nishinakamura |
MGI ID: |
MGI:5430391 |
Synonyms: |
Gt(Rosa)26Sortm1(Notch2)Nis, Gt(ROSA)26Sortm2(Notch2)Ryni, R26Notch2 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2(Notch2)Ryn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:185844
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm2(Notch2)Ryn expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Notch2 (MGI:97364) |
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Mutation details: The floxed neo/STOP cassette and a flag-tagged Notch2 fragment, which encompassed amino acids 1701 to 2470 and lacked the transmembrane domain or S3 cleavage site but contained the intact transactivation domain and C-terminal PEST sequences, were knocked into the locus.
(J:185844)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:185844 Fujimura S, et al., Notch2 activation in the embryonic kidney depletes nephron progenitors. J Am Soc Nephrol. 2010 May;21(5):803-10 |
All: |
5 reference(s) |
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