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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il4
interleukin 4
MGI:96556
74 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
involves: 129 * BALB/cJ * C57BL/6 		decreased basophil cell number J:181313
decreased IgE level J:181313
decreased IgG1 level J:181313
decreased interleukin-4 secretion J:181313
normal immune system phenotype J:181313
Faslpr/Faslpr
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp 		abnormal lymph node size J:39600
abnormal spleen size J:39600
decreased anti-nuclear antigen antibody level J:39600
decreased circulating creatinine level J:39600
decreased IgA level J:39600
decreased IgE level J:39600
decreased IgG1 level J:39600
decreased IgG3 level J:39600
decreased immunoglobulin level J:39600
decreased susceptibility to systemic lupus erythematosus J:39600
enlarged spleen J:39600
increased spleen weight J:39600
spleen hyperplasia J:39600
Faslpr/Faslpr
Il4tm1Cgn/Il4tm1Cgn
MRL.Cg-Il4tm1Cgn Faslpr 		glomerulonephritis J:132514
lacrimal gland inflammation J:132514
Fbn1Tsk/Fbn1+
Il4tm1Nnt/Il4tm1Nnt
involves: C57BL/6 * C57BL/10 * DBA/2 		decreased interleukin-4 secretion J:57957
emphysema J:57957
normal integument phenotype J:57957
Il2tm1Hor/Il2tm1Hor
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal susceptibility to Riboviria infection J:26861
decreased cytotoxic T cell cytolysis J:26861
decreased IgG level J:16662, J:26861
increased B cell proliferation J:16662
increased pre-B cell number J:16662
increased pro-B cell number J:16662
increased T cell proliferation J:16662
Il4/Il13tm1.1Lky/Il4/Il13tm1.1Lky
Il4/Il13tm1.1Lky/Il4/Il13tm1.1Lky
involves: 129P2/OlaHsd * BALB/c 		decreased core body temperature J:178294
decreased fatty acids level J:178294
decreased noradrenaline level J:178294
increased susceptibility to weight loss J:178294
Il4tm1(CD2)Irvr/Il4+
involves: 129P2/OlaHsd * C57BL/6 		normal cellular phenotype J:111440
normal immune system phenotype J:111440
Il4tm1.1Wep/Il4+
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Il4tm1.1Wep 		abnormal T-helper 2 cell differentiation J:138827
decreased IgE level J:138827
impaired eosinophil recruitment J:138827
Il4tm1.1Wep/Il4tm1.1Wep
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Il4tm1.1Wep 		abnormal T-helper 2 cell differentiation J:138827
decreased IgE level J:138827
impaired eosinophil recruitment J:138827
Il4tm1Cgn/Il4tm1Cgn
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
involves: 129P2/OlaHsd 		esophageal epithelium hyperplasia J:205692
esophageal inflammation J:205692
increased CD4-positive, alpha-beta T cell number J:205692
increased eosinophil cell number J:205692
increased inflammatory response J:205692
increased interleukin-2 secretion J:205692
increased neutrophil cell number J:205692
increased T cell number J:205692
lung epithelium hyperplasia J:205692
lung inflammation J:205692
premature death J:205692
Il4tm1Cgn/Il4tm1Cgn
Tg(CD2-Stat6*V625A*T626A)78Mhk/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		normal integument phenotype J:160119
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi 		decreased susceptibility to autoimmune diabetes J:85924
insulitis J:85924
Il4tm1Gru/Il4tm1Gru
C.129-Il4tm1Gru 		no abnormal phenotype detected J:53107
Il4tm1Kopf/Il4tm1Kopf
Lyntm1Ard/Lyntm1Ard
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal circulating complement protein level J:161523
decreased B cell number J:161523
decreased IgE level J:161523
decreased IgG1 level J:161523
increased anti-double stranded DNA antibody level J:161523
increased anti-nuclear antigen antibody level J:161523
increased basophil cell number J:161523
increased IgA level J:161523
increased IgG2a level J:161523
increased IgG2b level J:161523
increased IgM level J:161523
increased mast cell number J:161523
Il4tm1Lky/Il4+
Lattm1.1Mal/Lattm1.1Mal
involves: 129S2/SvPas * C57BL/6 		abnormal T-helper 2 physiology J:151840
Il4tm1Lky/Il4tm1Lky
Itktm1Litt/Itktm1Litt
involves: 129S4/SvJae * BALB/c * C57BL/6J 		abnormal cell death J:129883
abnormal cytokine secretion J:129883
abnormal response to infection J:129883
abnormal T-helper 2 physiology J:129883
normal immune system phenotype J:129883
Il4tm2Nnt/Il4tm2Nnt
Tgfb1tm1Doe/Tgfb1tm1Doe
C.Cg-Tgfb1tm1Doe Il4tm2Nnt 		increased circulating alanine transaminase level J:69346
liver inflammation J:69346
postnatal lethality, complete penetrance J:69346
Il10tm1Cgn/Il10tm1Cgn
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 cell differentiation J:111712
increased interferon-gamma secretion J:111712
Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJae 		decreased eosinophil cell number J:178986
increased susceptibility to parasitic infection J:178986
Il13tm1Anjm/Il13+
Il4tm1.1Wep/Il4+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		decreased interleukin-4 secretion J:69099
Il21rtm1Wjl/Il21rtm1Wjl
Il4tm1Cgn/Il4tm1Cgn
involves: 129 * C57BL/6 		abnormal immunoglobulin level J:80474
abnormal lymph node germinal center morphology J:80474
decreased IgA level J:80474
decreased IgG1 level J:80474
decreased IgG2a level J:80474
decreased IgG2b level J:80474
decreased IgG3 level J:80474
decreased IgM level J:80474
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory