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Transgene Detail
Symbol: Tg(CD2-Stat6*V625A*T626A)78Mhk
Name: transgene insertion 78, Mark H Kaplan
MGI ID: MGI:3845883
Synonyms: Stat6VT, StatVT
Transgene: Tg(CD2-Stat6*V625A*T626A)78Mhk  Location: unknown  
Alliance: Tg(CD2-Stat6*V625A*T626A)78Mhk page
Strain of Origin:  C3H
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(CD2-Stat6*V625A*T626A)78Mhk expresses 1 gene
Mutation detailsThis transgene expresses the human STAT6 gene, with codons V625 and T626 mutated to express alanine and a C-terminal FLAG tag added, under transcriptional control of the CD2 locus control region. This promoter restricted expression of the transgene primarily to B and T lymphocytes. In addition to line 78, founder line 24 was also established. (J:133480)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Phenotypic Similarity to Human Syndrome: Ocular Atopic Dermatitis J:230018.
Original:  J:133480 Bruns HA, et al., Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol. 2003 Apr 1;170(7):3478-87
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory