About   Help   FAQ
Il4tm1Kopf
Targeted Allele Detail
Summary
Symbol: Il4tm1Kopf
Name: interleukin 4; targeted mutation 1, Manfred Kopf
MGI ID: MGI:2176268
Synonyms: IL-4-, IL-4null
Gene: Il4  Location: Chr11:53503287-53509492 bp, - strand  Genetic Position: Chr11, 31.97 cM
Alliance: Il4tm1Kopf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:14593
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into the third exon of the gene. (J:14593)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  42 strains or lines available
References
Original:  J:14593 Kopf M, et al., Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 1993 Mar 18;362(6417):245-8
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory