Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Kopf mutation
(4 available);
any
Il4 mutation
(42 available)
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immune system
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• following exposure to an antigen, mice exhibit reduced eosinophil infiltration (0.60+/-0.17x105 cells/ml compared to 3.15+/-0.66x105 in wild-type mice)
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• IgE levels are undetectable (less than 10 ng/ml compared to 3300+/-1300 ng/ml in wild-type mice)
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• mice fail to secrete IL-5 after cross-linking of the CD3/TCR complex
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hematopoietic system
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• following exposure to an antigen, mice exhibit reduced eosinophil infiltration (0.60+/-0.17x105 cells/ml compared to 3.15+/-0.66x105 in wild-type mice)
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• IgE levels are undetectable (less than 10 ng/ml compared to 3300+/-1300 ng/ml in wild-type mice)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Kopf mutation
(4 available);
any
Il4 mutation
(42 available)
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immune system
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• unlike in wild-type mice, IgE levels are undetectable prior to and following immunization
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• IgG1 levels are reduced 20-fold compared to in wild-type mice and following immunization IgG1 levels are 12-fold lower than in immunized wild-type mice
• following immunization with DNP-ovalbumin, IgG1 antibodies are 10-fold lower than in wild-type mice
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• following infection with N. brasiliensis, IgG2 and IgG3 levels are slightly higher than in wild-type mice
• following immunization with DNP-ovalbumin, IgG2 and IgG3 levels are 100- to 500-fold higher than in wild-type mice
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• stimulated CD4+ T cells in vitro fail to produce IL-10
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• in stimulated CD4+ T cells, the production of IL-3 is reduced more than 70% of wild-type value
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• stimulated CD4+ T cells in vitro fail to produce IL-4
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• stimulated CD4+ T cells in vitro fail to produce IL-5
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• following infection with N. brasiliensis, CD4+ T cells produce reduced levels of Th2 cytokines, increased levels of interferon-gamma, and reduced blood eosinophilia levels compared to infected wild-type mice
• however, CD8+ T cells do produce IL-5 following infection with N. brasiliensis
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hematopoietic system
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• unlike in wild-type mice, IgE levels are undetectable prior to and following immunization
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• IgG1 levels are reduced 20-fold compared to in wild-type mice and following immunization IgG1 levels are 12-fold lower than in immunized wild-type mice
• following immunization with DNP-ovalbumin, IgG1 antibodies are 10-fold lower than in wild-type mice
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• following infection with N. brasiliensis, IgG2 and IgG3 levels are slightly higher than in wild-type mice
• following immunization with DNP-ovalbumin, IgG2 and IgG3 levels are 100- to 500-fold higher than in wild-type mice
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hematopoietic system
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• in the bone marrow, blood and spleen
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immune system
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• in the bone marrow, blood and spleen
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• increased circulating immune complexes reactive to complement component 1 q
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• yet decreased compared to Lyn single mutant
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• yet decreased compared to Lyn single mutant
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homeostasis/metabolism