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Tgfbr2
Gene Detail
 Symbol
Name
ID
Tgfbr2
transforming growth factor, beta receptor II
MGI:98729
Synonyms 1110020H15Rik, TbetaRII, TbetaR-II, TBR-II
Feature Type protein coding gene
Genetic Map
Chromosome 9
68.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:116087698-116175363 bp, - strand
From Ensembl annotation of GRCm38

  87666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor-beta receptor, type II
Gene Tree: Tgfbr2

Human
homologs
Human Homolog TGFBR2, transforming growth factor, beta receptor II (70/80kDa)
NCBI Gene ID 7048
neXtProt AC  NX_P37173
Human Synonyms  AAT3, FAA3, LDS1B, LDS2B, MFS2, RIIC, TAAD2, TGFbeta-RII, TGFR-2
Human Chr (Location)  3p22; chr3:30606502-30694142 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human TGFBR2
Alleles
and
phenotypes
All alleles(10) : Targeted(10)
 
Homozygotes for targeted null mutations die in midgestation with impaired yolk sac hematopoiesis and vasculogenesis. Selective knockouts in bone marrow cells and cranial neural crest show inflammation and cleft palate/calvarial defects, respectively.
 
Human Diseases Modeled Using Mouse Tgfbr2 (4)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (101 annotations)
Process activation of protein kinase activity, apoptotic process, ...
Component caveola, cell surface, ...
Function ATP binding, glycosaminoglycan binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (307)    Tissues (180)    Images (46)
Theiler Stages: 2, 3, 9, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 162
Western blot 22
RT-PCR 87
RNase protection 19
cDNA source data(122)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(131) Genomic(1) cDNA(122) Primer pair(8)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032440 (Evidence)
Entrez Gene21813 (Evidence)
UniGene172346
DFCITC1575335, TC1579112, TC1607433, TC1621595, TC1737701
DoTSDT.101379137, DT.491510, DT.94381729, DT.97368389, DT.97376912
EC2.7.11.30
Consensus CDS ProjectCCDS23601.1, CCDS23602.1
International Mouse Knockout Project StatusTgfbr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032440 Ensembl Gene Model | MGI Sequence Detail 87666 C57BL/6J ±  kb
transcript ENSMUST00000061101 Ensembl | MGI Sequence Detail 4785 Not Applicable 
polypeptide ENSMUSP00000062333 Ensembl | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(678 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR015013 Transforming growth factor beta receptor 2 ectodomain
InterPro IPR017194 Transforming growth factor-beta receptor, type II
Protein Ontology PR:000000005 TGF-beta receptor type-2
References (Earliest) J:1339 Massague J, Receptors for the TGF-beta family. Cell. 1992 Jun 26;69(7):1067-70
(Latest) J:206729 Fan Q, et al., Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res. 2014 Jan 15;74(2):471-83
All references(273)
Other
accession IDs
MGD-MRK-15071, MGI:1923554, MGI:2143233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory