Cd4tm1(cre/ERT2)Thbu/Cd4+
Tgfbr2tm1Karl/Tgfbr2tm1Karl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
normal
growth/size/body region phenotype |
J:204579
|
|
normal
immune system phenotype |
J:204579
|
|
increased memory T cell number |
J:204579
|
|
increased regulatory T cell number |
J:204579
|
Cd19tm1(cre)Cgn/Cd19+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * BALB/c
|
abnormal B cell physiology |
J:90558
|
|
abnormal B-1 B cell morphology |
J:90558
|
|
abnormal B-1 B cell number |
J:90558
|
|
absent plasma cells |
J:90558
|
|
decreased IgA level |
J:90558
|
|
enlarged Peyer's patches |
J:90558
|
|
increased IgG level |
J:90558
|
|
increased IgM level |
J:90558
|
|
increased leukocyte cell number |
J:90558
|
Dcttm1(cre)Bee/Dcttm1(cre)Bee
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Tg(Dct-lacZ)A12Jkn/0
involves: 129/Sv * C57BL/6 * C57BL/6J * CBA
|
abnormal coat/hair pigmentation |
J:157070
|
|
abnormal hair follicle melanocyte morphology |
J:157070
|
|
ectopic hair follicle melanin granules |
J:157070
|
|
ectopic melanocytes |
J:157070
|
|
pigment incontinence |
J:157070
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal pancreas development |
J:116129
|
Tg(CAG-cre/Esr1*)5Amc/0
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S6/SvEvTac * C57BL/6 * CBA
|
abnormal electroretinogram waveform feature |
J:221181
|
|
abnormal pericyte morphology |
J:221181
|
|
abnormal retina blood vessel morphology |
J:221181
|
|
abnormal retina layer morphology |
J:221181
|
|
abnormal retina morphology |
J:221181
|
|
abnormal retina neuronal layer morphology |
J:221181
|
|
abnormal retina vasculature morphology |
J:221181
|
|
decreased a-wave amplitude |
J:221181
|
|
decreased b-wave amplitude |
J:221181
|
|
decreased retina ganglion cell number |
J:221181
|
|
hypoxia |
J:221181
|
|
increased retina apoptosis |
J:221181
|
|
microgliosis |
J:221181
|
|
persistence of hyaloid vascular system |
J:221181
|
|
retina detachment |
J:221181
|
|
retina hemorrhage |
J:221181
|
|
retina microaneurysm |
J:221181
|
|
retina neovascularization |
J:221181
|
|
thin retina outer nuclear layer |
J:221181
|
|
vitreous body hemorrhage |
J:221181
|
Tgfbr2em1(IMPC)Rbrc/Tgfbr2+
C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc
|
abnormal heart morphology |
J:211773
|
|
abnormal kidney morphology |
J:211773
|
|
abnormal liver morphology |
J:211773
|
|
enlarged heart |
J:211773
|
|
enlarged kidney |
J:211773
|
|
small liver |
J:211773
|
Tgfbr2em1(IMPC)Rbrc/Tgfbr2em1(IMPC)Rbrc
C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc
|
preweaning lethality, complete penetrance |
J:211773
|
Tgfbr2tm1.1Hcd/Tgfbr2+
129S6(Cg)-Tgfbr2tm1.1Hcd
|
abnormal aorta bulb morphology |
J:204960
|
|
abnormal aorta elastic fiber morphology |
J:204960
|
|
abnormal aortic arch morphology |
J:204960
|
|
abnormal coronary artery morphology |
J:204960
|
|
aortic dissection |
J:204960
|
|
ascending aorta aneurysm |
J:204960
|
|
dilated aorta bulb |
J:204960
|
|
hemopericardium |
J:204960
|
|
hemothorax |
J:204960
|
|
increased aorta wall thickness |
J:204960
|
|
kyphosis |
J:204960
|
|
premature death |
J:204960
|
Tgfbr2tm1.1Hlm/Tgfbr2tm1.1Hlm
involves: 129S6/SvEvTac * C57BL/6
|
preweaning lethality, complete penetrance |
J:75073
|
Tgfbr2tm1.1Karl/Tgfbr2tm1.1Karl
involves: 129/Sv * C57BL/6
|
abnormal erythropoiesis |
J:77844
|
|
absent vitelline blood vessels |
J:77844
|
|
decreased embryo size |
J:77844
|
|
enlarged pericardium |
J:77844
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S6/SvEvTac * C57BL/6
|
normal
neoplasm |
J:177379
|
|
no abnormal phenotype detected |
J:75073
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
|
normal
cardiovascular system phenotype |
J:164749
|
|
decreased cardiac muscle contractility |
J:164749
|
|
dilated cardiomyopathy |
J:164749
|
|
premature death |
J:164749
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6 * CBA
|
abnormal aortic arch morphology |
J:104325
|
|
abnormal brain dura mater morphology |
J:86042
|
|
abnormal cranium morphology |
J:86042
|
|
abnormal dorsal aorta morphology |
J:104325
|
|
abnormal fourth pharyngeal arch artery morphology |
J:104325
|
|
abnormal mandible morphology |
J:86042
|
|
abnormal neurocranium morphology |
J:86042
|
|
abnormal palatal mesenchymal cell proliferation |
J:86042
|
|
abnormal palate morphology |
J:86042
|
|
abnormal parietal bone morphology |
J:86042
|
|
abnormal soft palate muscle morphology |
J:208431
|
|
absent frontal bone |
J:86042
|
|
absent mandibular angle |
J:86042
|
|
cleft secondary palate |
J:86042
|
|
decreased cranial neural crest cell proliferation |
J:86042
|
|
interrupted aortic arch, type b |
J:104325
|
|
palatal shelf hypoplasia |
J:86042
|
|
palatal shelves fail to meet at midline |
J:86042
|
|
persistent truncus arteriosus |
J:104325
|
|
postnatal lethality, complete penetrance |
J:104325
|
|
retroesophageal right subclavian artery |
J:104325
|
|
small cranium |
J:86042
|
|
small mandible |
J:86042
|
|
small mandibular condyloid process |
J:86042
|
|
small mandibular coronoid process |
J:86042
|
|
small maxilla |
J:86042
|
|
ventricular septal defect |
J:104325
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Acvrl1-cre)L1Spo/0
involves: 129S6/SvEvTac * FVB/N
|
normal
cardiovascular system phenotype |
J:130020
|
|
no abnormal phenotype detected |
J:130020
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD
|
increased inflammatory response |
J:196160
|
|
premature death |
J:196160
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
abnormal T cell activation |
J:148747
|
|
autoimmune response |
J:148747
|
|
liver inflammation |
J:148747
|
|
postnatal lethality, complete penetrance |
J:148747
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J
|
decreased Langerhans cell number |
J:126147
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
increased prostate gland adenocarcinoma incidence |
J:204736
|
|
increased prostate intraepithelial neoplasia incidence |
J:204736
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(KRT14-cre)52Smr/0
involves: 129S6/SvEvTac * C57BL/6J * SJL/J
|
abnormal hard palate morphology |
J:112634
|
|
abnormal nasal septum morphology |
J:112634
|
|
abnormal palatal shelf fusion at midline |
J:112634
|
|
abnormal palatal shelf morphology |
J:112634
|
|
abnormal palate development |
J:112634
|
|
abnormal primary palate development |
J:112634
|
|
abnormal skeletal muscle fiber morphology |
J:208431
|
|
abnormal soft palate morphology |
J:208431
|
|
abnormal soft palate muscle morphology |
J:208431
|
|
absent gastric milk in neonates |
J:112634
|
|
centrally nucleated skeletal muscle fibers |
J:208431
|
|
cleft secondary palate |
J:112634
|
|
cleft soft palate |
J:208431
|
|
neonatal lethality |
J:112634
|
|
small levator veli palatini muscle |
J:208431
|
|
small tensor veli palatini muscle |
J:208431
|
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Twist2tm1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6
|
abnormal branching involved in lung morphogenesis |
J:143910
|
|
abnormal bronchial cartilage morphology |
J:143910
|
|
abnormal bronchus morphology |
J:143910
|
|
abnormal lung lobe morphology |
J:143910
|
|
abnormal tracheal cartilage morphology |
J:143910
|
|
decreased tracheal cartilage ring number |
J:143910
|
|
dilated respiratory conducting tube |
J:143910
|
|
lethality throughout fetal growth and development, complete penetrance |
J:143910
|
Tgfbr2tm1Dgen/Tgfbr2+
involves: 129P2/OlaHsd
|
abnormal fat pad morphology |
J:148831
|
|
increased fatty acids level |
J:148831
|
|
increased total body fat amount |
J:148831
|
Tgfbr2tm1Hlm/Tgfbr2tm1Hlm
involves: 129S6/SvEvTac * C57BL/6
|
preweaning lethality, complete penetrance |
J:75073
|
Tgfbr2tm1Karl/Tgfbr2tm1Karl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
no abnormal phenotype detected |
J:77844
|
Tgfbr2tm1Karl/Tgfbr2tm1Karl
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal aortic arch and aortic arch branch attachment |
J:96359
|
|
abnormal blood vessel physiology |
J:96359
|
|
abnormal cartilage morphology |
J:96359
|
|
abnormal craniofacial bone morphology |
J:96359
|
|
abnormal hindbrain morphology |
J:96359
|
|
abnormal midbrain morphology |
J:96359
|
|
abnormal neural crest cell morphology |
J:96359
|
|
abnormal parathyroid gland morphology |
J:96359
|
|
abnormal vasodilation |
J:96359
|
|
absent parathyroid glands |
J:96359
|
|
blood vessel congestion |
J:96359
|
|
cleft secondary palate |
J:96359
|
|
congestive heart failure |
J:96359
|
|
palatal shelves fail to meet at midline |
J:96359
|
|
parathyroid hypoplasia |
J:96359
|
|
perinatal lethality |
J:96359
|
|
persistent truncus arteriosus |
J:96359
|
|
small thymus |
J:96359
|
|
ventricular septal defect |
J:96359
|
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(AMELX-cre)A1Kul/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NCr
|
abnormal enamel mineralization |
J:205404
|
|
abnormal enamel morphology |
J:205404
|
|
abnormal molar morphology |
J:205404
|
|
abnormal tooth attrition |
J:205404
|
|
reduced enamel thickness |
J:205404
|
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal stationary movement |
J:77844
|
|
eye inflammation |
J:77844
|
|
increased inflammatory response |
J:77844
|
|
liver inflammation |
J:77844
|
|
pancreas inflammation |
J:77844
|
|
paralysis |
J:77844
|
|
premature death |
J:77844
|
|
small thymus |
J:77844
|
|
stomach inflammation |
J:77844
|
|
weight loss |
J:77844
|
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ
|
abnormal vitelline vasculature morphology |
J:98373
|
|
prenatal lethality, complete penetrance |
J:98373
|
Tgfbr2tm1Mmt/Tgfbr2tm1Mmt
involves: 129S2/SvPas * C57BL/6J
|
abnormal embryonic hematopoiesis |
J:73414
|
|
abnormal vitelline vasculature morphology |
J:73414
|
|
embryonic growth retardation |
J:73414
|
|
embryonic lethality during organogenesis, complete penetrance |
J:73414
|
|
pale yolk sac |
J:73414
|
Tgfbr2tm1Sjkm/Tgfbr2+
Not Specified
|
increased hepatocyte proliferation |
J:71591
|
|
increased incidence of tumors by chemical induction |
J:71591
|
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