Cd4tm1(cre/ERT2)Thbu
Targeted Allele Detail
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Symbol: |
Cd4tm1(cre/ERT2)Thbu |
Name: |
CD4 antigen; targeted mutation 1, Thorsten Buch |
MGI ID: |
MGI:5549971 |
Synonyms: |
CD4-CreERt2 |
Gene: |
Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
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Alliance: |
Cd4tm1(cre/ERT2)Thbu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:204579
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Cd4tm1(cre/ERT2)Thbu expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cd4 (MGI:88335) |
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Mutation details: A targeting vector was designed to replace part of exon 2 including the ATG codon of the Cd4 locus with the cre/ERT2 fusion gene and Frt-flanked neo marker. Homologous recombination in ES cells generated the knock-in allele.
(J:204579)
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Generation of Cd4tm1(cre/ERT2)Thbu. |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cd4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd4 Mutation: |
82 strains or lines available
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Original: |
J:204579 Sledzinska A, et al., TGF-beta signalling is required for CD4(+) T cell homeostasis but dispensable for regulatory T cell function. PLoS Biol. 2013 Oct;11(10):e1001674 |
All: |
20 reference(s) |
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