About   Help   FAQ
Dcttm1(cre)Bee
Targeted Allele Detail
Summary
Symbol: Dcttm1(cre)Bee
Name: dopachrome tautomerase; targeted mutation 1, Friedrich Beermann
MGI ID: MGI:2387116
Synonyms: Dct-, DctCre, Dct - KO
Gene: Dct  Location: Chr14:118250202-118289656 bp, - strand  Genetic Position: Chr14, 61.6 cM
Alliance: Dcttm1(cre)Bee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79094
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Dcttm1(cre)Bee expression driven by 1 gene
 
Mutation detailsExon 1, which is the first coding exon, was replaced with a cassette containing cre and neo. RT-PCR indicated an absence of normal transcript in homozygous mice. Normal protein was undetected by Western blot analysis of skin extracts and by immunohistochemical analysis of embryonic retinal pigment epithelium. (J:89896)
Inheritance:    Recessive
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dct (mouse)
Summary of all recombinase alleles driven by Dct.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dct Mutation:  35 strains or lines available
References
Original:  J:79094 Guyonneau L, et al., Expression of cre recombinase in pigment cells. Pigment Cell Res. 2002 Aug;15(4):305-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/05/2024
MGI 6.24
The Jackson Laboratory