|
Symbol Name ID |
Tgfbr2
transforming growth factor, beta receptor II MGI:98729 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hepatosplenomegaly |
Peritoneal abscess |
Incisional hernia |
Inguinal hernia |
Umbilical hernia |
Reduced upper to lower segment ratio |
Tall stature |
Disproportionate tall stature |
Weight loss |
| Disease(s) Associated with TGFBR2 | |||||||||
| Loeys-Dietz syndrome 2 | |||||||||
| Lynch syndrome | |||||||||
| Marfan syndrome | |||||||||
| pancreatic cancer |
| Mouse Phenotypes | enlarged heart |
abnormal molar morphology |
abnormal enamel mineralization |
abnormal enamel morphology |
reduced enamel thickness |
abnormal tooth attrition |
abnormal palate development |
abnormal palatal mesenchymal cell proliferation |
abnormal primary palate development |
abnormal palatal shelf morphology |
abnormal palatal shelf fusion at midline |
palatal shelves fail to meet at midline |
palatal shelf hypoplasia |
abnormal palate morphology |
abnormal hard palate morphology |
abnormal soft palate morphology |
abnormal soft palate muscle morphology |
small levator veli palatini muscle |
small tensor veli palatini muscle |
cleft soft palate |
cleft secondary palate |
abnormal nasal septum morphology |
embryonic growth retardation |
decreased embryo size |
growth/size/body region phenotype |
weight loss |
cachexia |
enlarged kidney |
enlarged spleen |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Tgfbr2tm1.1Karl/Tgfbr2tm1.1Karl | ||||||||||||||||||||||||||||||
| Tgfbr2tm1Mmt/Tgfbr2tm1Mmt | ||||||||||||||||||||||||||||||
| Tgfbr2em1(IMPC)Rbrc/Tgfbr2+ | ||||||||||||||||||||||||||||||
| Tg(CD2-Tgfbr2)1Grs/0 | ||||||||||||||||||||||||||||||
| Tg(CD2-Tgfbr2)1Grs/? | ||||||||||||||||||||||||||||||
| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(KRT14-cre)52Smr/0 (conditional) |
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| Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Tgfbr2tm1Karl/Tgfbr2tm1Karl H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(AMELX-cre)A1Kul/0 (conditional) |
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| Cd4tm1(cre/ERT2)Thbu/Cd4+ Tgfbr2tm1Karl/Tgfbr2tm1Karl (conditional) |
* | |||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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