|
Symbol Name ID |
Tgfbr2
transforming growth factor, beta receptor II MGI:98729 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukemia |
Hematological neoplasm |
Lymphoma |
Non-Hodgkin lymphoma |
T-cell lymphoma |
Adenoma sebaceum |
Salivary gland neoplasm |
Breast carcinoma |
Esophageal carcinoma |
Neoplasm of the rectum |
Adenocarcinoma of the colon |
Hereditary nonpolyposis colorectal carcinoma |
Adenomatous colonic polyposis |
Colon cancer |
Intestinal polyposis |
Neoplasm of the stomach |
Neoplasm of the liver |
Hepatocellular carcinoma |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Adenocarcinoma of the small intestine |
Pituitary adenoma |
Neoplasm of the thyroid gland |
Ovarian neoplasm |
Ovarian carcinoma |
Endometrial carcinoma |
Renal neoplasm |
Malignant genitourinary tract tumor |
Urinary tract neoplasm |
Neoplasm of the skin |
Basal cell carcinoma |
Plexiform neurofibroma |
Rhabdomyosarcoma |
Neoplasm of the skeletal system |
Astrocytoma |
Pleomorphic xanthoastrocytoma |
Ependymoma |
Glioblastoma multiforme |
Oligodendroglioma |
Benign neoplasm of the central nervous system |
Medulloblastoma |
Neuroblastoma |
Laryngeal carcinoma |
Melanoma |
| Disease(s) Associated with TGFBR2 | ||||||||||||||||||||||||||||||||||||||||||||
| esophageal cancer | ||||||||||||||||||||||||||||||||||||||||||||
| hereditary nonpolyposis colorectal cancer type 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||||||||||||||||
| mismatch repair cancer syndrome | ||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | neoplasm |
increased prostate gland adenocarcinoma incidence |
increased prostate intraepithelial neoplasia incidence |
increased T cell derived lymphoma incidence |
increased incidence of tumors by chemical induction |
increased leukemia incidence |
|
| Availability | Mouse Genotype | ||||||
| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm | * | ||||||
| Tgfbr2tm1Sjkm/Tgfbr2+ | |||||||
| Tg(CD2-Tgfbr2)1Grs/? | |||||||
| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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