55 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Cd4-cre)1Cwi/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2	normal immune system phenotype	J:148747
Hprt1tm1(CAG-Tgfbr1*)Lba/Y Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Cd4-cre)1Cwi/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2	normal immune system phenotype	J:148747
Ifngtm1Ts/Ifngtm1Ts Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL	normal immune system phenotype	J:196160
	normal mortality/aging	J:196160
Krastm4Tyj/Kras+ Tgfbr2tm1.2Hlm/Tgfbr2+ Ptf1atm1.1(cre)Cvw/Ptf1a+ involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2	increased metastatic potential	J:116129
	increased pancreas tumor incidence	J:116129
	increased pancreatic ductal adenocarcinoma incidence	J:116129
	increased pancreatic intraepithelial neoplasia incidence	J:116129
	premature death	J:116129
Krastm4Tyj/Kras+ Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm	abnormal myeloid leukocyte morphology	J:177379
	increased B cell number	J:177379
	increased lung adenocarcinoma incidence	J:177379
	increased metastatic potential	J:177379
	increased T cell number	J:177379
	premature death	J:177379
Krastm4Tyj/Kras+ Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Ptf1atm1.1(cre)Cvw/Ptf1a+ involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal duodenum morphology	J:116129
	abnormal hepatic portal vein morphology	J:116129
	abnormal hepatic portal vein thrombosis	J:116129
	dilated gallbladder	J:116129
	distended abdomen	J:116129
	enlarged spleen	J:116129
	hemorrhagic ascites	J:116129
	hepatic necrosis	J:116129
	increased metastatic potential	J:116129
	increased pancreas tumor incidence	J:116129
	increased pancreatic ductal adenocarcinoma incidence	J:116129
	increased pancreatic intraepithelial neoplasia incidence	J:116129
	jaundice	J:116129
	paralysis	J:116129
	premature death	J:116129
	weight loss	J:116129
Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Tgfbr2tm1Roes/Tgfbr2tm1Roes involves: 129P2/OlaHsd * C57BL/6 * DBA	abnormal cholangiocyte morphology	J:228499
	increased liver weight	J:228499
	liver fibrosis	J:228499
Tg(Acta2-cre/ERT2)#Pcn/0 Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(H2-K-Fosl2,-EGFP)13Wag/0 B6.Cg-Tgfbr2tm1Karl Tg(Acta2-cre/ERT2)#Pcn Tg(H2-K-Fosl2,-EGFP)13Wag	normal cardiovascular system phenotype	J:238723
	lung inflammation	J:238723
	pulmonary fibrosis	J:238723
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Cd4-cre)1Cwi/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL	abnormal abdominal lymph node morphology	J:196160
	abnormal immune serum protein physiology	J:196160
	abnormal immune system morphology	J:196160
	abnormal immune system organ morphology	J:196160
	abnormal immune system physiology	J:196160
	abnormal interleukin secretion	J:196160
	abnormal spleen morphology	J:196160
	decreased interleukin-9 secretion	J:196160
	decreased interleukin-17 secretion	J:196160
	decreased regulatory T cell number	J:196160
	normal immune system phenotype	J:196160
	increased interferon-gamma secretion	J:196160
	increased interleukin-2 secretion	J:196160
	increased interleukin-21 secretion	J:196160
	increased regulatory T cell number	J:196160
	increased susceptibility to autoimmune diabetes	J:196160
	normal mortality/aging	J:196160
	pancreas inflammation	J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Foxp3-EGFP/cre)1cJbs/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL	normal immune system phenotype	J:196160
	increased regulatory T cell number	J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tnfrsf4tm2(cre)Nik/Tnfrsf4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: 129 * C57BL/6 * NOD * SJL	normal immune system phenotype	J:196160
	increased susceptibility to autoimmune diabetes	J:196160
Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(Tagln-cre)1Her/? Gt(ROSA)26Sortm1Sor/? involves: 129 * C57BL/6 * SJL	abnormal heart morphology	J:128498
	abnormal vitelline vasculature morphology	J:128498
	delayed brain development	J:128498
	delayed heart development	J:128498
	embryonic growth retardation	J:128498
	lethality throughout fetal growth and development, complete penetrance	J:128498
	pale yolk sac	J:128498
Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(Tie1-cre)9Ref/? Gt(ROSA)26Sortm1Sor/? involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal pharyngeal arch morphology	J:128498
	abnormal vitelline vasculature morphology	J:128498
	absent vitelline blood vessels	J:128498
	embryonic growth retardation	J:128498
	embryonic lethality during organogenesis, complete penetrance	J:128498
	pericardial effusion	J:128498