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Rho
Gene Detail
 Symbol
Name
ID
Rho
rhodopsin
MGI:97914
STS D6Mit44
Synonyms Long Wavelength Sensitive opsin, L opsin, LWS opsin, MGC:21585, MGC:25387, Noerg1, Opn2, Ops, opsin 2, Red Opsin, Rod Opsin, RP4
Feature Type protein coding gene
Genetic Map
Chromosome 6
53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr6:115931927-115938829 bp, + strand
From Ensembl annotation of GRCm38

  6903 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: animal opsin
Gene Tree: Rho

Human
homologs
Human Homolog RHO, rhodopsin
NCBI Gene ID 6010
neXtProt AC  NX_P08100
Human Synonyms  CSNBAD1, OPN2, RP4
Human Chr (Location)  3q21-q24; chr3:129528639-129535344 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human RHO
Alleles
and
phenotypes
All alleles(19) : Chemically induced (ENU)(4) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation fail to develop retinal rod outer segments and lose their photoreceptors. Heterozygotes exhibit some disorganization of their photoreceptors and a shortening of the outer segments with age.
 
Human Diseases Modeled Using Mouse Rho (1)    Alleles Annotated to Human Diseases(9)    Phenotype Images(11)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cellular response to light stimulus, detection of light stimulus, ...
Component cell-cell junction, Golgi apparatus, ...
Function G-protein coupled receptor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (101 records)
Data Summary: Results (151)    Tissues (59)    Images (47)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 45
Northern blot 1
Western blot 8
RT-PCR 73
RNase protection 17
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) Genomic(11) cDNA(22) Primer pair(7) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000030324 (Evidence)
Entrez Gene212541 (Evidence)
DFCITC1573783, TC1604357
DoTSDT.102558053, DT.94402484, DT.94402488, DT.94402494, DT.97375400, DT.97379985
NIA Mouse Gene IndexU007301
Consensus CDS ProjectCCDS20446.1
International Mouse Knockout Project StatusRho
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030324 Ensembl Gene Model | MGI Sequence Detail 6903 C57BL/6J ±  kb
transcript ENSMUST00000032471 Ensembl | MGI Sequence Detail 3235 Not Applicable 
polypeptide ENSMUSP00000032471 Ensembl | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(2)
Polymorphisms All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001760 Opsin
InterPro IPR000732 Rhodopsin
InterPro IPR019477 Rhodopsin, N-terminal
InterPro IPR027430 Visual pigments (opsins) retinal binding site
Protein Ontology PR:000001245 rhodopsin
References (Earliest) J:32330 Baehr W, et al., Isolation and analysis of the mouse opsin gene. FEBS Lett. 1988 Oct 10;238(2):253-6
(Latest) J:207143 Sakami S, et al., P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41
All references(287)
Other
accession IDs
MGD-MRK-13042, MGD-MRK-13866, MGI:2661843

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory