About   Help   FAQ
Rho Gene Detail
Summary
  • Symbol
    Rho
  • Name
    rhodopsin
  • Synonyms
    Long Wavelength Sensitive opsin, L opsin, LWS opsin, MGC:21585, MGC:25387, Noerg1, Opn2, Ops, opsin 2, Red Opsin, Rod Opsin, RP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97914
    NCBI Gene: 212541
  • Gene Overview
    MyGene.info: RHO
Location & Maps
more
  • Sequence Map
    Chr6:115931748-115940036 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      8289 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    21 experiments
  • Sequence Tag
    D6Mit44
Homology
more
  • Human Ortholog
    RHO, rhodopsin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHO, rhodopsin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNBAD1, OPN2, RP4
  • Links
    NCBI Gene ID: 6010
    neXtProt AC: NX_P08100
    UniProt: P08100

  • Chr Location
    3q22.1; chr3:129528639-129535344 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Rho mouse models; 3 with human RHO associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 12 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 17 alleles in 21 genetic backgrounds
    19 phenotypes from multigenic genotypes
    12 images
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null homozygotes fail to develop retinal rod outer segments and lose their photoreceptors while heterozygotes exhibit some disorganization of their photoreceptors and a shortening of the outer segments with age. Some point mutants have only light-induced photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    180
  • Tissues
    63
  • cDNA Data
    19
  • Literature Summary
    121
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056681 VEGA Gene Model | MGI Sequence Detail 8289 C57BL/6J ±  kb
transcript OTTMUST00000139898 VEGA | MGI Sequence Detail 4621 Not Applicable  
polypeptide OTTMUSP00000073385 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    118 from dbSNP Build 142
  • PCR
    1
  • RFLP
    5
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 11
    cDNA 22
    Primer pair 9
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-13042, MGD-MRK-13866, MGI:2661843
References
more
  • Summaries
    All 345
    Developmental Gene Expression 121
    Diseases 10
    Gene Ontology 30
    Phenotypes 135
  • Earliest
    J:32330 Baehr W, et al., Isolation and analysis of the mouse opsin gene. FEBS Lett. 1988 Oct 10;238(2):253-6
  • Latest
    J:241542 Athanasiou D, et al., Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15;26(2):305-319
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory