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Rho Gene Detail
Summary
  • Symbol
    Rho
  • Name
    rhodopsin
  • Synonyms
    Long Wavelength Sensitive opsin, L opsin, LWS opsin, MGC:21585, MGC:25387, Noerg1, Opn2, Ops, opsin 2, Red Opsin, Rod Opsin, RP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97914
    NCBI Gene: 212541
  • Gene Overview
    MyGene.info: RHO
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115931748-115940036 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    21 experiments
  • Sequence Tag
    D6Mit44
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97914
 protein coding gene Chr6:115926754-115940036 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031159
 protein coding gene Chr6:118578343-118586623 (+)
A/J MGP_AJ_G0031129
 protein coding gene Chr6:114028195-114036483 (+)
AKR/J MGP_AKRJ_G0031059
 protein coding gene Chr6:117080115-117088409 (+)
BALB/cJ MGP_BALBcJ_G0031139
 protein coding gene Chr6:113833454-113841742 (+)
C3H/HeJ MGP_C3HHeJ_G0030569
 protein coding gene Chr6:67212947-67221237 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031598
 protein coding gene Chr6:121598640-121606930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028762
 protein coding gene Chr6:111026744-111034486 (+)
CAST/EiJ MGP_CASTEiJ_G0030246
 protein coding gene Chr6:117455981-117464282 (+)
CBA/J MGP_CBAJ_G0030825
 protein coding gene Chr6:126369705-126377996 (+)
DBA/2J MGP_DBA2J_G0030979
 protein coding gene Chr6:112944488-112952768 (+)
FVB/NJ MGP_FVBNJ_G0030932
 protein coding gene Chr6:112124125-112132406 (+)
LP/J MGP_LPJ_G0031058
 protein coding gene Chr6:118581998-118590278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030967
 protein coding gene Chr6:130532061-130540341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031626
 protein coding gene Chr6:117106037-117114317 (+)
PWK/PhJ MGP_PWKPhJ_G0029962
 protein coding gene Chr6:111960302-111968813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029790
 protein coding gene Chr6:115831371-115839641 (+)
WSB/EiJ MGP_WSBEiJ_G0030330
 protein coding gene Chr6:117369837-117378125 (+)



Homology
more
  • Human Ortholog
    RHO, rhodopsin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHO, rhodopsin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNBAD1, OPN2, RP4
  • Links
    NCBI Gene ID: 6010
    neXtProt AC: NX_P08100
    UniProt: P08100

  • Chr Location
    3q22.1; chr3:129528639-129535344 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Rho mouse models; 3 with human RHO associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 13 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 18 alleles in 22 genetic backgrounds
    19 phenotypes from multigenic genotypes
    17 images
    151 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted null homozygotes fail to develop retinal rod outer segments and lose their photoreceptors while heterozygotes exhibit some disorganization of their photoreceptors and a shortening of the outer segments with age. Some point mutants have only light-induced photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    222
  • Tissues
    67
  • cDNA Data
    20
  • Literature Summary
    144
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030324 Ensembl Gene Model | MGI Sequence Detail 8289 C57BL/6J ±  kb
    transcript ENSMUST00000032471 Ensembl | MGI Sequence Detail 4621 Not Applicable  
    polypeptide ENSMUSP00000032471 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 11
      cDNA 23
      Primer pair 11
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13042, MGD-MRK-13866, MGI:2661843
    References
    more
    • Summaries
      All 398
      Developmental Gene Expression 144
      Diseases 11
      Gene Ontology 31
      Phenotypes 151
    • Earliest
      J:32330 Baehr W, et al., Isolation and analysis of the mouse opsin gene. FEBS Lett. 1988 Oct 10;238(2):253-6
    • Latest
      J:275842 Garnai SJ, et al., Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice. PLoS Genet. 2019 May;15(5):e1008130
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory