Rho
Gene Detail

Symbol Name ID

Rho rhodopsin MGI:97914

STS

D6Mit44

Synonyms

Long Wavelength Sensitive opsin, L opsin, LWS opsin, MGC:21585, MGC:25387, Noerg1, Opn2, Ops, opsin 2, Red Opsin, Rod Opsin, RP4

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr6:115931927-115938829 bp, + strand From Ensembl annotation of GRCm38   6903 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: animal opsin
Gene Tree: Rho

Human homologs

Human Homolog		RHO, rhodopsin
NCBI Gene ID		6010
neXtProt AC		NX_P08100
Human Synonyms		CSNBAD1, OPN2, RP4
Human Chr (Location)		3q21-q24; chr3:129247482-129254187 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human RHO

Alleles and phenotypes

All alleles(17) : Targeted(13) Chemically induced(4)
 

Homozygotes for a targeted null mutation fail to develop retinal rod outer segments and lose their photoreceptors. Heterozygotes exhibit some disorganization of their photoreceptors and a shortening of the outer segments with age.

 
Human Diseases Modeled Using Mouse Rho (1)    Alleles Annotated to Human Diseases(8)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	cellular response to light stimulus, detection of light stimulus, ...
Component	Golgi apparatus, integral to membrane, ...
Function	G-protein coupled receptor activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (99 records)
Data Summary: Results (148)    Tissues (59)    Images (44)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	45
Northern blot	1
Western blot	8
RT-PCR	73
RNase protection	17

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(11) cDNA(22) Primer pair(7) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000030324 (Evidence)
Entrez Gene	212541 (Evidence)
DFCI	TC1573783, TC1604357
DoTS	DT.102558053, DT.94402484, DT.94402488, DT.94402494, DT.97375400, DT.97379985
NIA Mouse Gene Index	U007301
Consensus CDS Project	CCDS20446.1
International Mouse Knockout Project Status	Rho

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030324	Ensembl Gene Model | MGI Sequence Detail	6903	C57BL/6J
transcript	ENSMUST00000032471	Ensembl | MGI Sequence Detail	3235	Not Applicable
polypeptide	ENSMUSP00000032471	Ensembl | MGI Sequence Detail	348	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(80 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR001760	Opsin
InterPro	IPR000732	Rhodopsin
InterPro	IPR019477	Rhodopsin, N-terminal
InterPro	IPR027430	Visual pigments (opsins) retinal binding site
Protein Ontology	PR:000001245	rhodopsin

References

(Earliest) J:32330 Baehr W, et al., Isolation and analysis of the mouse opsin gene. FEBS Lett. 1988 Oct 10;238(2):253-6
(Latest) J:202013 Du Y, et al., Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16586-91
All references(277)

Other accession IDs

MGD-MRK-13042, MGD-MRK-13866, MGI:2661843