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Transgene Detail
Symbol: Tg(Rho)1Wbae
Name: transgene insertion 1, Wolfgang Baehr
MGI ID: MGI:2686794
Synonyms: VPP
Transgene: Tg(Rho)1Wbae  Location: unknown  
Alliance: Tg(Rho)1Wbae page
Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6 x SJL
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Rho)1Wbae expresses 1 gene
Mutation detailsThe transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus. (J:12791)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:12791 Naash MI, et al., Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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