Rhotm1.1(RHO*/TagRFP-T)Twe
Targeted Allele Detail
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Symbol: |
Rhotm1.1(RHO*/TagRFP-T)Twe |
Name: |
rhodopsin; targeted mutation 1.1, Theodore G Wensel |
MGI ID: |
MGI:8221592 |
Synonyms: |
P23HhRhoRFP, P23H-hRho-TagRFP, P23H-Rho-RFP |
Gene: |
Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
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Alliance: |
Rhotm1.1(RHO*/TagRFP-T)Twe page
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: The endogenous gene was replaced with a human RHO gene with a P23H mutation, a C terminal fusion to the fluorescent Tag-RFP-T and a lox511-flanked HPRT minigene via homologous recombination. An additional 1D4 signaling sequence was added to the carboxy-terminus in case the C-terminal RFP fusion tag may inhibit the endogenous Rho 1D4 sequence. Cre mediated recombination removed the HPRT minigene.
(J:346249)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rho Mutation: |
49 strains or lines available
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Original: |
J:346249 Robichaux MA, et al., Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa. Dis Model Mech. 2022 May 1;15(5):dmm049336 |
All: |
1 reference(s) |
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