Phenotypes Associated with This Genotype

Genotype
MGI:4947235

• Allelic Composition: Rho^tm1.1Kpal/Rho⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retinal degeneration in Rho^tm1.1Kpal/Rho⁺ and Rho^tm1.1Kpal/Rho^tm1.1Kpal mice

vision/eye

abnormal retina layer morphology ( J:170648 )

• the distance between retina pigmented epithelium and the outer limiting membrane is reduced compared to in wild-type mice

decreased retina rod cell number ( J:170648 )

• half the number in wild-type mice

short retina rod cell outer segment ( J:170648 )

• shortened at P35 and P112

disorganized photoreceptor outer segment ( J:170648 )

• at P63

retina rod cell degeneration ( J:170648 )

• due to necrosis

thin retina outer nuclear layer ( J:170648 )

• at P63

abnormal cone electrophysiology ( J:170648 )

• continuous decline until P276

• mildly reduced at P70

• severely depressed at P170

abnormal rod electrophysiology ( J:170648 )

• severely reduced at P41

• nearly undetectable by P170

nervous system

decreased retina rod cell number ( J:170648 )

• half the number in wild-type mice

short retina rod cell outer segment ( J:170648 )

• shortened at P35 and P112

disorganized photoreceptor outer segment ( J:170648 )

• at P63

retina rod cell degeneration ( J:170648 )

• due to necrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:170648