Phenotypes for Rho Rpe65 MGI:4455027 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rho^Tvrm4/Rho⁺ Rpe65^rd12/Rpe65^rd12
Genetic Background	B6.Cg-Rpe65^rd12 Rho^Tvrm4

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rho^Tvrm4 mutation (2 available); any Rho mutation (53 available)
Rpe65^rd12 mutation (1 available); any Rpe65 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Photoreceptor degeneration without exposure to bright light in Rpe65^rd12/Rpe65^rd12 Rho^Tvrm4/Rho⁺ mice

vision/eye

retina photoreceptor degeneration ( J:159523 )

• photoreceptor degeneration without exposure to bright light

• the peripheral retina also shows cell loss but is better preserved than the central retina

retina outer nuclear layer degeneration ( J:159523 )

• at 4 weeks of age, retinas have only 2-3 rows of cell bodies remaining in the central outer nuclear layer

nervous system

retina photoreceptor degeneration ( J:159523 )

• photoreceptor degeneration without exposure to bright light

• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa		DOID:10584	OMIM:268000 OMIM:PS268000	J:159523

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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