Jak2
Gene Detail

Symbol Name ID

Jak2 Janus kinase 2 MGI:96629

Synonyms

C81284

Feature Type

protein coding gene

Genetic Map

Chromosome 19

23.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr19:29251828-29313080 bp, + strand From NCBI annotation of GRCm38   61253 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak2

Human homologs

Human Homolog		JAK2, Janus kinase 2
NCBI Gene ID		3717
neXtProt AC		NX_O60674
Human Synonyms		JTK10, THCYT3
Human Chr (Location)		9p24; chr9:4985245-5128183 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human JAK2

Alleles and phenotypes

All alleles(15) : Targeted(12) Gene trapped(3)
 

Homozygotes for null mutations die during midgestation due to a failure of erythropoieses. Mice expressing a conditional allele activated in mammary tissue exhibit lactation deficiency due to impaired alveologenesis. Mice homozygous for a knock-in allele exhibit myeloproliferative neoplasm.

 
Human Diseases Modeled Using Mouse Jak2 (3)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (127 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, ...
Component	caveola, cytoplasm, ...
Function	acetylcholine receptor binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (250)    Tissues (72)    Images (25)
Theiler Stages: 2, 15, 20, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	200
Western blot	3
RT-PCR	46

cDNA source data(86)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(92) Genomic(2) cDNA(86) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024789 (Evidence)
Entrez Gene	16452 (Evidence)
UniGene	275839
DFCI	TC1580801, TC1620219, TC1640491, TC1682205
DoTS	DT.101735148, DT.532402, DT.94255102, DT.94255103
NIA Mouse Gene Index	U043720
EC	2.7.10.2
PDB	2HDX
Consensus CDS Project	CCDS37950.1
International Mouse Knockout Project Status	Jak2

Sequences

Length	Strain/Species
genomic	16452	NCBI Gene Model | MGI Sequence Detail	61253	C57BL/6J
transcript	NM_008413	RefSeq | MGI Sequence Detail	5030	C57BL/6
polypeptide	Q62120	UniProt | EBI | MGI Sequence Detail	1129	Not Applicable

All sequences(39) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(378 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019748	FERM central domain
InterPro	IPR000299	FERM domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR020693	Tyrosine-protein kinase, non-receptor Jak2
InterPro	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology	PR:000009197	tyrosine-protein kinase JAK2

Graphical View of Protein Domain Structure

References

(Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:194747 Bell BD, et al., The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013 Apr;14(4):364-71
All references(155)

Other accession IDs

MGD-MRK-11517, MGI:2147569, MGI:2147795