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Jak2
Gene Detail
 Symbol
Name
ID
Jak2
Janus kinase 2
MGI:96629
Synonyms C81284
Feature Type protein coding gene
Genetic Map
Chromosome 19
23.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr19:29251828-29313080 bp, + strand
From NCBI annotation of GRCm38

  61253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak2

Human
homologs
Human Homolog JAK2, Janus kinase 2
NCBI Gene ID 3717
neXtProt AC  NX_O60674
Human Synonyms  JTK10, THCYT3
Human Chr (Location)  9p24; chr9:4985245-5129948 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human JAK2
Alleles
and
phenotypes
All alleles(19) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations die during midgestation due to a failure of erythropoieses. Mice expressing a conditional allele activated in mammary tissue exhibit lactation deficiency due to impaired alveologenesis. Mice homozygous for a knock-in allele exhibit myeloproliferative neoplasm.
 
Human Diseases Modeled Using Mouse Jak2 (3)    Alleles Annotated to Human Diseases(4)   
Gene Ontology
(GO)
classifications
All GO classifications: (137 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, ...
Component caveola, cytoplasm, ...
Function acetylcholine receptor binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (250)    Tissues (72)    Images (25)
Theiler Stages: 2, 15, 20, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 200
Western blot 3
RT-PCR 46
cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(93) Genomic(2) cDNA(87) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024789 (Evidence)
Entrez Gene16452 (Evidence)
UniGene275839
DFCITC1580801, TC1620219, TC1640491, TC1682205
DoTSDT.101735148, DT.532402, DT.94255102, DT.94255103
NIA Mouse Gene IndexU043720
EC2.7.10.2
PDB2HDX, 4GL9
Consensus CDS ProjectCCDS37950.1
International Mouse Knockout Project StatusJak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16452 NCBI Gene Model | MGI Sequence Detail 61253 C57BL/6J ±  kb
transcript NM_008413 RefSeq | MGI Sequence Detail 5055 C57BL/6 
polypeptide Q62120 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020693 Tyrosine-protein kinase, non-receptor Jak2
InterPro IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology PR:000009197 tyrosine-protein kinase JAK2
Graphical View of Protein Domain Structure
References (Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:210481 Shi SY, et al., Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing. Diabetologia. 2014 May;57(5):1016-26
All references(179)
Other
accession IDs
MGD-MRK-11517, MGI:2147569, MGI:2147795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory