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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jak2
Janus kinase 2
MGI:96629
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
DccTg(H2-Kb-Jak2*V617F)1Shmd/Dcc+
involves: C57BL/6 * DBA/2 		abnormal definitive hematopoiesis J:130189
abnormal megakaryocyte morphology J:130189
abnormal neutrophil morphology J:130189
abnormal spleen morphology J:130189
decreased erythroid progenitor cell number J:130189
decreased hematocrit J:130189
decreased spleen white pulp amount J:130189
enhanced megakaryocyte emperipolesis J:130189
enlarged spleen J:130189
increased bone marrow cell number J:130189
increased erythroblast number J:130189
increased granulocyte number J:130189
increased leukocyte cell number J:130189
increased megakaryocyte cell number J:130189
increased spleen red pulp amount J:130189
increased spleen weight J:130189
myeloid hyperplasia J:130189
polycythemia J:130189
thrombocytosis J:130189
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
increased erythrocyte cell number J:220728
increased hematocrit J:220728
increased hemoglobin content J:220728
reticulocytosis J:220728
thrombocytosis J:220728
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		abnormal iron homeostasis J:220728
decreased CD4-positive, alpha-beta T cell number J:220728
decreased CD8-positive, alpha-beta T cell number J:220728
decreased erythrocyte cell number J:220728
decreased hematocrit J:220728
decreased hemoglobin content J:220728
decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
hypochromic microcytic anemia J:220728
reticulocytosis J:220728
Plek2tm1Pji/Plek2tm1Pji
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal cell differentiation J:257910
abnormal granulocyte differentiation J:257910
abnormal megakaryocyte differentiation J:257910
extramedullary hematopoiesis J:257910
normal hematopoietic system phenotype J:257910
normal homeostasis/metabolism phenotype J:257910
normal immune system phenotype J:257910
premature death J:257910
Tg(H2-Kb-Jak2*V617F)2Shmd/0
involves: C57BL/6 * DBA/2 		abnormal definitive hematopoiesis J:130189
abnormal megakaryocyte morphology J:130189
abnormal spleen morphology J:130189
anemia J:130189
decreased erythroblast number J:130189
decreased erythrocyte cell number J:130189
decreased erythroid progenitor cell number J:130189
decreased hematocrit J:130189
decreased hemoglobin content J:130189
enhanced megakaryocyte emperipolesis J:130189
enlarged spleen J:130189
giant platelets J:130189
increased compact bone thickness J:130189
increased leukocyte cell number J:130189
increased megakaryocyte cell number J:130189
increased neutrophil cell number J:130189
increased number of Howell-Jolly bodies J:130189
increased spleen red pulp amount J:130189
increased spleen weight J:130189
myelofibrosis J:130189
myeloid hyperplasia J:130189
polychromatophilia J:130189
spleen fibrosis J:130189
thrombocytosis J:130189
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory