Plek2^tm1Pji
Targeted Allele Detail

Summary

• Symbol: Plek2^tm1Pji
• Name: pleckstrin 2; targeted mutation 1, Peng Ji
• MGI ID: MGI:6162244
• Gene: Plek2 Location: Chr12:78935465-78953738 bp, - strand Genetic Position: Chr12, 35.51 cM, cytoband D3
• Alliance: Plek2^tm1Pji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257910
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin resistance gene. Western blot analysis confirmed absence of protein in bone marrow mononuclear cells. (J:257910)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plek2 Mutation: 17 strains or lines available

References

• Original: J:257910 Zhao B, et al., Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018 Jan 2;128(1):125-140
• All: 2 reference(s)