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Phenotypes Associated with This Genotype
Genotype
MGI:5444033
Allelic
Composition
DccTg(H2-Kb-Jak2*V617F)1Shmd/Dcc+
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DccTg(H2-Kb-Jak2*V617F)1Shmd mutation (0 available); any Dcc mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• splenomegaly is seen at 3-5 months of age in some mutants
• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

hematopoietic system
• increase in number of CD41+ cells and Gr-1/Mac1 double-positive cells in the bone marrow and spleen
• decrease in the percentage of B220+ B cells in the bone marrow and spleen
• increase in numbers of mature myeloid cells in spleen
• femurs exhibit hypercellular bone marrow with maturing myeloid cells, erythrocytes in many stages of differentiation, and mature megakaryocytes
• megakaryocytes in the spleen are large in size and have multilobulated nuclei
• increase in the number of megakaryocytes in the bone marrow
• decrease in the percentage of erythroid precursor cells in the bone marrow
• increase in the percentage of erythroblasts in spleen
• 8 of 43 mutants show polycythemia at 3 months of age
• increase in the percentage of neutrophil precursor cells in the bone marrow
• 15 of 43 mutants exhibit thrombocytosis
• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes
• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis
• granulocytosis after 4 months of age
• architecture of spleen is barely preserved
• splenomegaly is seen at 3-5 months of age in some mutants
• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis
• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells
• emperipolesis of neutrophils in megakaryocyte cytoplasm is seen in the femurs; this is rarely observed in wild-type mice

immune system
• increase in numbers of mature myeloid cells in spleen
• increase in the percentage of neutrophil precursor cells in the bone marrow
• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes
• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis
• granulocytosis after 4 months of age
• architecture of spleen is barely preserved
• splenomegaly is seen at 3-5 months of age in some mutants
• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis
• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/24/2023
MGI 6.22
The Jackson Laboratory