Ins1
Gene Detail

Symbol Name ID

Ins1 insulin I MGI:96572

Feature Type

protein coding gene

Genetic Map

Chromosome 19

46.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr19:52264323-52265456 bp, + strand From Ensembl annotation of GRCm38   1134 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7383  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: insulin
Gene Tree: Ins1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	carbohydrate metabolic process, glucose metabolic process, ...
Component	cytoplasm, extracellular region, ...
Function	chaperone binding, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (287 records)
Data Summary: Results (177)    Tissues (59)    Images (81)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	81
RNA in situ	9
RT-PCR	87

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(122) Genomic(1) cDNA(103) Primer pair(15) Other(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000035804 (Evidence)
Entrez Gene	16333 (Evidence)
UniGene	46269
DFCI	TC1573962, TC1639288
DoTS	DT.103583704, DT.110879591, DT.55100404
NIA Mouse Gene Index	U019565
PDB	1L6Q
Consensus CDS Project	CCDS29898.1
International Mouse Knockout Project Status	Ins1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000035804	Ensembl Gene Model | MGI Sequence Detail	1134	C57BL/6J
transcript	ENSMUST00000039652	Ensembl | MGI Sequence Detail	1016	Not Applicable
polypeptide	ENSMUSP00000049095	Ensembl | MGI Sequence Detail	108	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(6) : PCR(5) RFLP(1) SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004825	Insulin
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
Protein Ontology	PR:000009189	insulin-1

References

(Earliest) J:4914 Lalley PA, et al., Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):515 (Abstr.) (399-616)
(Latest) J:193959 Georgia S, et al., DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15;27(4):372-7
All references(366)

Other accession IDs

MGD-MRK-11410, MGD-MRK-11413, MGD-MRK-11415