About   Help   FAQ
Ins1
Gene Detail
Symbol

Name
ID
Ins1
insulin I
MGI:96572
Feature Type
protein coding gene
Genetic Map
Chromosome 19
46.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr19:52264323-52265456 bp, + strand
From Ensembl annotation of GRCm38

  1134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7383  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: insulin
Gene Tree: Ins1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Ins1 interacts with 97 markers (Mir23b, Mir25, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process carbohydrate metabolic process, glucose metabolic process, ...
Component cytoplasm, cytosol, ...
Function chaperone binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (334 records)
Data Summary: Results (231)    Tissues (72)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 111
RNA in situ 9
RT-PCR 111
cDNA source data(104)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) Genomic(1) cDNA(105) Primer pair(15) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000035804 (Evidence)
Entrez Gene 16333 (Evidence)
UniGene 46269
DFCI TC1573962, TC1639288
DoTS DT.103583704, DT.110879591, DT.55100404
NIA Mouse Gene Index U019565
PDB 1L6Q, 3WS3
Consensus CDS Project CCDS29898.1
International Mouse Phenotyping Consortium Status Ins1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035804 Ensembl Gene Model | MGI Sequence Detail 1134 C57BL/6J ±  kb
transcript ENSMUST00000039652 Ensembl | MGI Sequence Detail 1016 Not Applicable 
polypeptide ENSMUSP00000049095 Ensembl | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(6) : PCR(5) RFLP(1) SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004825 Insulin
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009189 insulin-1
References
(Earliest) J:4914 Lalley PA, et al., Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):515 (Abstr.) (399-616)
(Latest) J:220324 De Vas MG, et al., Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82
All references(412)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11410, MGD-MRK-11413, MGD-MRK-11415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory