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Ins1
Gene Detail
 Symbol
Name
ID
Ins1
insulin I
MGI:96572
Feature Type protein coding gene
Genetic Map
Chromosome 19
46.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr19:52264323-52265456 bp, + strand
From Ensembl annotation of GRCm38

  1134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7383  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: insulin
Gene Tree: Ins1

Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, glucose metabolic process, ...
Component cytoplasm, extracellular region, ...
Function chaperone binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (308 records)
Data Summary: Results (193)    Tissues (58)    Images (97)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 97
RNA in situ 9
RT-PCR 87
cDNA source data(104)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(124) Genomic(1) cDNA(105) Primer pair(15) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000035804 (Evidence)
Entrez Gene16333 (Evidence)
UniGene46269
DFCITC1573962, TC1639288
DoTSDT.103583704, DT.110879591, DT.55100404
NIA Mouse Gene IndexU019565
PDB1L6Q, 3WS3
Consensus CDS ProjectCCDS29898.1
International Mouse Knockout Project StatusIns1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035804 Ensembl Gene Model | MGI Sequence Detail 1134 C57BL/6J ±  kb
transcript ENSMUST00000039652 Ensembl | MGI Sequence Detail 1016 Not Applicable 
polypeptide ENSMUSP00000049095 Ensembl | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(6) : PCR(5) RFLP(1) SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004825 Insulin
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009189 insulin-1
References (Earliest) J:4914 Lalley PA, et al., Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):515 (Abstr.) (399-616)
(Latest) J:208336 Kesavan G, et al., Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development. 2014 Feb;141(3):685-96
All references(388)
Other
accession IDs
MGD-MRK-11410, MGD-MRK-11413, MGD-MRK-11415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory