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Ins1 Gene Detail
Summary
  • Symbol
    Ins1
  • Name
    insulin I
  • Feature Type
    protein coding gene
  • IDs
    MGI:96572
    NCBI Gene: 16333
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:52264297-52265015 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 46.76 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96572
protein coding gene Chr19:52264297-52265476 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025241
protein coding gene Chr19:52345404-52346535 (+)
A/J MGP_AJ_G0025217
protein coding gene Chr19:49739360-49740493 (+)
AKR/J MGP_AKRJ_G0025186
protein coding gene Chr19:51340466-51341599 (+)
BALB/cJ MGP_BALBcJ_G0025212
protein coding gene Chr19:49822308-49823441 (+)
C3H/HeJ MGP_C3HHeJ_G0024972
protein coding gene Chr19:51498788-51499921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025655
protein coding gene Chr19:53601834-53602967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023067
protein coding gene Chr19:48769063-48770197 (+)
CAST/EiJ MGP_CASTEiJ_G0024436
protein coding gene Chr19:51440203-51441340 (+)
CBA/J MGP_CBAJ_G0024952
protein coding gene Chr19:56208275-56209408 (+)
DBA/2J MGP_DBA2J_G0025084
protein coding gene Chr19:49552933-49554066 (+)
FVB/NJ MGP_FVBNJ_G0025045
protein coding gene Chr19:49266656-49267789 (+)
LP/J MGP_LPJ_G0025170
protein coding gene Chr19:52167683-52168814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025076
protein coding gene Chr19:55736242-55737375 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025713
protein coding gene Chr19:51482819-51483952 (+)
PWK/PhJ MGP_PWKPhJ_G0024185
protein coding gene Chr19:49456867-49458003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023988
protein coding gene Chr19:50177911-50179040 (+)
WSB/EiJ MGP_WSBEiJ_G0024507
protein coding gene Chr19:51626851-51627984 (+)



Homology
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Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    35 phenotypes from multigenic genotypes
    3 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16333 NCBI Gene Model | MGI Sequence Detail 719 C57BL/6J ±  kb
transcript NM_008386 RefSeq | MGI Sequence Detail 611 C57BL/6  
polypeptide P01325 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 127
    Genomic 1
    cDNA 106
    Primer pair 16
    Other 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11410, MGD-MRK-11413, MGD-MRK-11415
References
more
  • Summaries
    All 580
    Developmental Gene Expression 409
    Diseases 4
    Gene Ontology 7
    Phenotypes 50
  • Earliest
    J:4914 Lalley PA, et al., Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):515 (Abstr.) (399-616)
  • Latest
    J:278268 Stefan-Lifshitz M, et al., Epigenetic modulation of beta cells by interferon-alpha via PNPT1/mir-26a/TET2 triggers autoimmune diabetes. JCI Insight. 2019 Mar 7;4(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory