Fgfr2
Gene Detail

Symbol Name ID

Fgfr2 fibroblast growth factor receptor 2 MGI:95523

Synonyms

Bek, Fgfr-2, Fgfr7, Fgfr-7, KGFRTr, svs

Feature Type

protein coding gene

Genetic Map

Chromosome 7

73.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr7:130162451-133123350 bp, - strand From VEGA annotation of GRCm38   2960900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr2

Human homologs

Human Homolog		FGFR2, fibroblast growth factor receptor 2
NCBI Gene ID		2263
neXtProt AC		NX_P21802
Human Synonyms		BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, K-SAM, TK14, TK25
Human Chr (Location)		10q26; chr10:123237844-123357972 (-)  GRCh37.p10
Disease Associations		(11) Diseases Associated with Human FGFR2

Alleles and phenotypes

All alleles(113) : Targeted(27) Gene trapped(84) Spontaneous(1) Chemically induced(1)
 

Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.

 
Human Diseases Modeled Using Mouse Fgfr2 (5)    Alleles Annotated to Human Diseases(9)    Phenotype Images(15)

Gene Ontology (GO) classifications

All GO classifications: (168 annotations)

Process	angiogenesis, apoptotic process, ...
Component	cell cortex, cell surface, ...
Function	ATP binding, fibroblast growth factor-activated receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (266 records)
Data Summary: Results (824)    Tissues (430)    Images (203)
Theiler Stages: 2, 3, 4, 5, 6, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	29
RNA in situ	567
Northern blot	4
RT-PCR	224

cDNA source data(876)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(917) Genomic(3) cDNA(882) Primer pair(26) Other(6)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031222 (Evidence)
Ensembl Gene Model	ENSMUSG00000030849 (Evidence)
Entrez Gene	14183 (Evidence)
UniGene	16340
DoTS	DT.101365770, DT.101740973, DT.528387, DT.94146700, DT.94159570, DT.94159579, DT.94297839
NIA Mouse Gene Index	U029330
EC	2.7.10.1
Consensus CDS Project	CCDS52412.1, CCDS52413.1
International Mouse Knockout Project Status	Fgfr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031222	VEGA Gene Model | MGI Sequence Detail	2960900	C57BL/6J
transcript	OTTMUST00000077355	VEGA | MGI Sequence Detail	3323	Not Applicable
polypeptide	OTTMUSP00000040881	VEGA | MGI Sequence Detail	840	Not Applicable

All sequences(181) RefSeq(4) UniProt(41)

Polymorphisms

RFLP(2) : SNPs(567 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016248	Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology	PR:000001449	fibroblast growth factor receptor 2

References

(Earliest) J:9441 Shukri NM, et al., Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape. Genet Res. 1988 Aug;52(1):27-32
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(440)

Other accession IDs

MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454