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Fgfr2
Gene Detail
 Symbol
Name
ID
Fgfr2
fibroblast growth factor receptor 2
MGI:95523
Synonyms Bek, Fgfr-2, Fgfr7, Fgfr-7, KGFRTr, svs
Feature Type protein coding gene
Genetic Map
Chromosome 7
73.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr7:130162451-133123350 bp, - strand
From VEGA annotation of GRCm38

  2960900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr2

Human
homologs
Human Homolog FGFR2, fibroblast growth factor receptor 2
NCBI Gene ID 2263
neXtProt AC  NX_P21802
Human Synonyms  BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, K-SAM, TK14, TK25
Human Chr (Location)  10q26; chr10:121478330-121598458 (-)  GRCh38
Disease Associations  (11) Diseases Associated with Human FGFR2
Alleles
and
phenotypes
All alleles(115) : Targeted(29) Gene trapped(84) Spontaneous(1) Chemically induced(1)
 
Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.
 
Human Diseases Modeled Using Mouse Fgfr2 (5)    Alleles Annotated to Human Diseases(9)    Phenotype Images(20)
Gene Ontology
(GO)
classifications
All GO classifications: (172 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cell cortex, ...
Function ATP binding, fibroblast growth factor-activated receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (282 records)
Data Summary: Results (869)    Tissues (454)    Images (224)
Theiler Stages: 2, 3, 4, 5, 6, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 37
RNA in situ 602
Northern blot 4
RT-PCR 226
cDNA source data(878)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(919) Genomic(3) cDNA(884) Primer pair(26) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031222 (Evidence)
Ensembl Gene ModelENSMUSG00000030849 (Evidence)
Entrez Gene14183 (Evidence)
UniGene16340
DoTSDT.101365770, DT.101740973, DT.528387, DT.94146700, DT.94159570, DT.94159579, DT.94297839
NIA Mouse Gene IndexU029330
EC2.7.10.1
PDB4HWU
Consensus CDS ProjectCCDS52412.1, CCDS52413.1
International Mouse Knockout Project StatusFgfr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031222 VEGA Gene Model | MGI Sequence Detail 2960900 C57BL/6J ±  kb
transcript OTTMUST00000077355 VEGA | MGI Sequence Detail 3323 Not Applicable 
polypeptide OTTMUSP00000040881 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(203) RefSeq(26) UniProt(41)
Polymorphisms RFLP(2) : SNPs within 2kb(14935 from dbSNP Build 137)    SNPs within 2kb including multiple locations(14981)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology PR:000001449 fibroblast growth factor receptor 2
References (Earliest) J:9441 Shukri NM, et al., Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape. Genet Res. 1988 Aug;52(1):27-32
(Latest) J:206577 Green MJ, et al., Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1. Development. 2014 Jan;141(2):389-98
All references(464)
Other
accession IDs
MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory