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Fgfr2
Gene Detail
Symbol

Name
ID
Fgfr2
fibroblast growth factor receptor 2
MGI:95523
Synonyms
Bek, Fgfr-2, Fgfr7, Fgfr-7, KGFRTr, svs
Feature Type
protein coding gene
Genetic Map
Chromosome 7
73.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr7:130162451-133123350 bp, - strand
From VEGA annotation of GRCm38

  2960900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGFR2
Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr2

Human
homologs
FGFR2, fibroblast growth factor receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2263
neXtProt AC: NX_P21802

Human Synonyms: BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, K-SAM, TK14, TK25

Human Chr (Location): 10q26; chr10:121478330-121598656 (-)  GRCh38.p2

Disease Associations: (11) Diseases Associated with Human FGFR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(113) : Chemically induced (ENU)(2) Gene trapped(80) Spontaneous(1) Targeted(29) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.
 
Human Diseases Modeled in Mice Using Fgfr2 (4)    Mutations Annotated to Human Diseases (9)    Phenotype Images(28)
Interactions
Fgfr2 interacts with 397 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (172 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cell cortex, ...
Function ATP binding, fibroblast growth factor-activated receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (306 records)
Data Summary: Results (1147)    Tissues (623)    Images (281)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 41
RNA in situ 864
Northern blot 5
Western blot 3
RT-PCR 234
cDNA source data(880)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGFR2 ; Xenbase fgfr2 ; ZFIN fgfr2    NEW 
Molecular
reagents
All nucleic(925) Genomic(4) cDNA(886) Primer pair(29) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031222 (Evidence)
Ensembl Gene Model ENSMUSG00000030849 (Evidence)
Entrez Gene 14183 (Evidence)
UniGene 16340
DoTS DT.101365770, DT.101740973, DT.528387, DT.94146700, DT.94159570, DT.94159579, DT.94297839
NIA Mouse Gene Index U029330
EC 2.7.10.1
PDB 4HWU
Consensus CDS Project CCDS52412.1, CCDS52413.1
International Mouse Phenotyping Consortium Status Fgfr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031222 VEGA Gene Model | MGI Sequence Detail 2960900 C57BL/6J ±  kb
transcript OTTMUST00000077355 VEGA | MGI Sequence Detail 3323 Not Applicable 
polypeptide OTTMUSP00000040881 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(203) RefSeq(26) UniProt(41)
Polymorphisms
RFLP(2) : SNPs within 2kb(14935 from dbSNP Build 137)    SNPs within 2kb including multiple locations(14981)
Protein-related
information
ResourceIDDescription
InterPro IPR028175 Fibroblast growth factor receptor 2
InterPro IPR016248 Fibroblast growth factor receptor family
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000001449 fibroblast growth factor receptor 2
References
(Earliest) J:9441 Shukri NM, et al., Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape. Genet Res. 1988 Aug;52(1):27-32
(Latest) J:222294 Walker KA, et al., Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F888-98
All references(504)
Disease annotation references (12)
Other
accession IDs
MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory