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Hbb-bs Gene Detail
Summary
  • Symbol
    Hbb-bs
  • Name
    hemoglobin, beta adult s chain
  • Synonyms
    beta s
  • Feature Type
    protein coding gene
  • IDs
    MGI:5474852
    NCBI Gene: 100503605
  • Member of
    Hbb cluster
  • Gene Overview
    MyGene.info: HBB
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:103826523-103827928 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5474852
protein coding gene Chr7:103826523-103828096 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032683
protein coding gene Chr7:107036977-107038541 (-)
A/J MGP_AJ_G0032656
protein coding gene Chr7:104251438-104253002 (-)
AKR/J MGP_AKRJ_G0032589
protein coding gene Chr7:106755957-106757210 (-)
BALB/cJ MGP_BALBcJ_G0032666
protein coding gene Chr7:103978483-103980047 (-)
C3H/HeJ MGP_C3HHeJ_G0032377
protein coding gene Chr7:107112587-107114151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033162
protein coding gene Chr7:111026181-111026730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030158
protein coding gene Chr7:106328803-106344316 (-)
CAST/EiJ MGP_CASTEiJ_G0031708
protein coding gene Chr7:98645166-98666248 (-)
CBA/J MGP_CBAJ_G0032345
protein coding gene Chr7:114948770-114951877 (-)
DBA/2J MGP_DBA2J_G0032499
protein coding gene Chr7:102567071-102572337 (-)
FVB/NJ MGP_FVBNJ_G0032452
protein coding gene Chr7:102292060-102293473 (-)
LP/J MGP_LPJ_G0032592
protein coding gene Chr7:108350151-108351715 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032488
protein coding gene Chr7:116264254-116277570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033189
protein coding gene Chr7:105957129-105960355 (-)
PWK/PhJ MGP_PWKPhJ_G0031422
protein coding gene Chr7:95542935-95556878 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031266
protein coding gene Chr7:93226737-93237236 (-)
WSB/EiJ MGP_WSBEiJ_G0031822
protein coding gene Chr7:106671576-106689325 (-)



Homology
more
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HBB, hemoglobin subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    beta-globin, CD113t-C, ECYT6
  • Links
    NCBI Gene ID: 3043
    neXtProt AC: NX_P68871
    UniProt: P68871

  • Chr Location
    11p15.4; chr11:5225466-5227071 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with human HBB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hbb-bs
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100503605 NCBI Gene Model | MGI Sequence Detail 1406 C57BL/6J ±  kb
transcript NM_001201391 RefSeq | MGI Sequence Detail 639 C57BL/6  
polypeptide NP_001188320 RefSeq | MGI Sequence Detail 147 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 40
    cDNA 38
    Primer pair 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:32353 Weaver S, et al., The adult beta-globin genes of the single type mouse C57BL. Cell. 1981 May;24(2):403-11
  • Latest
    J:190446 Brown FC, et al., ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level. Blood Cells Mol Dis. 2013 Feb;50(2):86-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory