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Targeted Allele Detail
Symbol: Hbbtm2(HBG1,HBB*)Tow
Name: hemoglobin beta chain complex; targeted mutation 2, Timothy Townes
MGI ID: MGI:3790753
Synonyms: -1400-gamma-betaS, Hbbhbetas, Hbbtm2(HBB*)Tow, HbSS-Townes
Gene: Hbb  Location: unknown  Genetic Position: Chr7, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:134980
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
  Hbbtm2(HBG1,HBB*)Tow involves 2 genes/genome features (Hbb-b1, Hbb-b2) View all
Hbbtm2(HBG1,HBB*)Tow expresses 2 genes
Hbbtm2(HBG1,HBB*)Tow expression driven by 1 gene
Mutation detailsThe major and minor beta chains were replaced with a construct made of a 5.66 kb fragment of the human gamma chain including 1400 bp of 5' flanking sequence and a 4.1 kb fragment of the sickle cell form of human HBB in ES cells already containing a replacement of Hba complex with human HBA, Hbatm1(HBA)Tow. Cre-mediated recombination removed the floxed hygro cassette. (J:44160, J:134980)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:  48 strains or lines available
Original:  J:134980 Wu LC, et al., Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006 Aug 15;108(4):1183-8
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory