Ahsp^tm1Mjwe
Targeted Allele Detail

Summary

• Symbol: Ahsp^tm1Mjwe
• Name: alpha hemoglobin stabilizing protein; targeted mutation 1, Mitchell J Weiss
• MGI ID: MGI:2449154
• Synonyms: AHSP -, Eraf^tm1Deo
• Gene: Ahsp Location: Chr7:127902016-127902926 bp, + strand
• Alliance: Ahsp^tm1Mjwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77038
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the entire coding region. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:77038)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahsp Mutation: 1 strain or line available

References

• Original: J:77038 Kihm AJ, et al., An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature. 2002 Jun 13;417(6890):758-63
• All: 3 reference(s)