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Phenotypes Associated with This Genotype
Genotype
MGI:5896637
Allelic
Composition
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4+
Genetic
Background
involves: 129 * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1(HBA)Tow mutation (3 available); any Hba mutation (10 available)
Hbbtm2(HBG1,HBB*)Tow mutation (3 available); any Hbb mutation (48 available)
Slc12a4Rbc10 mutation (1 available); any Slc12a4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compared to sickle mice wild-type for Slc12a4

cellular
• mesangial proliferation
• centrilobular necrosis and congestion

mortality/aging
• decreased survival compared to sickle mice wild-type for Slc12a4

hematopoietic system
• compared to sickle mice wild-type for Slc12a4
• increased anemia compared to mutant mice wild-type for Slc12a4
• increased compared to sickle mice wild-type for Slc12a4
• increase in 86Rb efflux
• increased red cell density

liver/biliary system
• marked lobular inflammation
• numerous sickle cells are seen in the sinusoids
• centrilobular necrosis and congestion

cardiovascular system
• increased intra-alveolar leakage of red cells

renal/urinary system
• mesangial proliferation
• increase in the number of red cells in the tubules

respiratory system
• increased intra-alveolar leakage of red cells
• increased interstitial congestion

immune system
• compared to sickle mice wild-type for Slc12a4
• marked lobular inflammation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sickle cell anemia DOID:10923 OMIM:603903
J:227339


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/24/2023
MGI 6.22
The Jackson Laboratory