Tg(LCR-HBA2,LCR-HBB)11Cos
Transgene Detail

Summary

• Symbol: Tg(LCR-HBA2,LCR-HBB)11Cos
• Name: transgene insertion 11, Frank Costantini
• MGI ID: MGI:3794861
• Synonyms: alpha^Hbeta^S, NY1DD, NY-S
• Transgene: Tg(LCR-HBA2,LCR-HBB)11Cos Location: unknown
• Alliance: Tg(LCR-HBA2,LCR-HBB)11Cos page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LCR-HBA2,LCR-HBB)11Cos expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBA2 (3040)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

• Mutation details: Constructs expressing the human alpha globin 2 gene from the locus control region of the human beta globin gene and the human beta globin gene also from the human locus control region were coinjected to create a line of mice with cointegrated transgenes. Transgene expression is noted in red blood cells. (J:129579)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:129579 Fabry ME, et al., High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12150-4
• All: 31 reference(s)