Phenotypes for Hbb-b1 Hbb-b2 Tg(HBB*)L2Pai MGI:6306309 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hbb-b1^tm1Unc/Hbb-b1⁺ Hbb-b2^tm1Unc/Hbb-b2⁺ Tg(HBB*)L2Pai/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1^tm1Unc mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b2^tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
Tg(HBB*)L2Pai mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:97548 )

abnormal erythropoiesis ( J:97548 )

• active but ineffective erythropoiesis and hemolysis

decreased erythrocyte cell number ( J:97548 )

decreased hematocrit ( J:97548 )

decreased hemoglobin content ( J:97548 )

decreased mean corpuscular volume ( J:97548 )

increased red blood cell distribution width ( J:97548 )

anisocytosis ( J:97548 )

poikilocytosis ( J:97548 )

reticulocytosis ( J:97548 )

homeostasis/metabolism

increased circulating bilirubin level ( J:97548 )

immune system

enlarged spleen ( J:97548 )

growth/size/body

enlarged spleen ( J:97548 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:97548

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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