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Phenotypes Associated with This Genotype
Genotype
MGI:5582253
Allelic
Composition		 Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Genetic
Background		 B6;129-Hbb-b1tm1Unc Hbb-b2tm1Unc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1tm1Unc mutation (2 available); any Hbb-b1 mutation (8 available)
Hbb-b2tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:211331 )
• Fam123b mRNA levels are increased by 16-fold in the spleen

homeostasis/metabolism
increased circulating erythropoietin level ( J:211331 )
• very high serum erythropoietin concentrations

immune system
abnormal spleen morphology ( J:211331 )
• Fam123b mRNA levels are increased by 16-fold in the spleen

skeleton
abnormal bone marrow morphology ( J:211331 )
• Fam123b mRNA levels are increased by 10-fold in the bone marrow

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
beta thalassemia DOID:12241 OMIM:613985
 J:211331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory