Phenotypes Associated with This Genotype

Genotype
MGI:5510724

• Allelic Composition: Hbb^d3th/Hbb⁺; Tg(LCR-HBA1,LCR-HBB*)1Tow/0
• Genetic Background: involves: C57BL/6 * DBA/2J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:127701 )

• spleen is 2-4 times larger than control

anemia ( J:127701 )

• mild anemia

decreased erythrocyte cell number ( J:127701 )

• decreased red blood cell counts

decreased hematocrit ( J:127701 )

decreased hemoglobin content ( J:127701 )

• decreased hemoglobin concentration

anisopoikilocytosis ( J:127701 )

• 90% of deoxygenated cells exhibit sickled shapes as compared to 1% of the transgene only mice

• sickled erythrocytes have projections or spicules similar to human sickled cells

echinocytosis ( J:127701 )

reticulocytosis ( J:127701 )

• elevated reticulocyte counts

immune system

enlarged spleen ( J:127701 )

• spleen is 2-4 times larger than control

growth/size/body

enlarged spleen ( J:127701 )

• spleen is 2-4 times larger than control

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sickle cell anemia		DOID:10923	OMIM:603903	J:127701