Hbb^d3th
Spontaneous Allele Detail

Summary

• Symbol: Hbb^d3th
• Name: hemoglobin beta chain complex; beta-thalassemia
• MGI ID: MGI:1856047
• Synonyms: beta^major, beta^MDD, Hbb^d3(th), Hbb^th-1, Hbb^th1, Hbb^UNC
• Gene: Hbb Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Spontaneous
• Mutation: Deletion
• Hbb^d3th involves 1 genes/genome features (Hbb-b1) View all
• Mutation details: A 3.7 kb region, including the entire beta major globin gene and 2 kilobases of 5' flanking region, is deleted. A novel approximately 66 bp sequence ending in a poly(A) stretch was found to bridge the deletion. (J:8395)
• Inheritance: Not Specified

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Hbb Mutation: 48 strains or lines available

References

• Original: J:7209 Skow LC, et al., A mouse model for beta-thalassemia. Cell. 1983 Oct;34(3):1043-52
• All: 45 reference(s)