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Hbb-bt Gene Detail
Summary
  • Symbol
    Hbb-bt
  • Name
    hemoglobin, beta adult t chain
  • Synonyms
    beta t
Location & Maps
more
  • Sequence Map
    Chr7:103812524-103813996 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, Syntenic
Homology
more
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HBB, hemoglobin subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    beta-globin, CD113t-C
  • Links
    NCBI Gene ID: 3043
    neXtProt AC: NX_P68871

  • Chr Location
    11p15.5; chr11:5225466-5227071 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    7 with human HBB associations

Human Disease Mouse Models
       Alpha-Thalassemia   OMIM: 604131
Beta-Thalassemia   OMIM: 613985
Beta-Thalassemia, Dominant Inclusion Body Type   OMIM: 603902
Heinz Body Anemias   OMIM: 140700
Hemoglobin--Beta Locus; HBB   OMIM: 141900
Malaria, Susceptibility to   OMIM: 611162
Sickle Cell Anemia   OMIM: 603903
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hbb-bt
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019042 VEGA Gene Model | MGI Sequence Detail 1473 C57BL/6J ±  kb
transcript OTTMUST00000045657 VEGA | MGI Sequence Detail 703 Not Applicable  
polypeptide OTTMUSP00000020541 VEGA | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    72 from dbSNP Build 142
Molecular
Reagents
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  • All nucleic 20
    cDNA 18
    Primer pair 2
References
more
  • Summaries
    All 12
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:32353 Weaver S, et al., The adult beta-globin genes of the single type mouse C57BL. Cell. 1981 May;24(2):403-11
  • Latest
    J:33053 Hug BA, et al., Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol. 1996 Jun;16(6):2906-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory