About   Help   FAQ
Hbb-bt Gene Detail
Summary
  • Symbol
    Hbb-bt
  • Name
    hemoglobin, beta adult t chain
  • Synonyms
    beta t
  • Feature Type
    protein coding gene
  • IDs
    MGI:5474850
    NCBI Gene: 101488143
  • Member of
    Hbb cluster
  • Gene Overview
    MyGene.info: HBB
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:103812524-103813923 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5474850
protein coding gene Chr7:103812524-103813996 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032682
protein coding gene Chr7:107022223-107023670 (-)
A/J MGP_AJ_G0032655
protein coding gene Chr7:104234539-104235986 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0032665
protein coding gene Chr7:103963794-103965241 (-)
C3H/HeJ MGP_C3HHeJ_G0032376
protein coding gene Chr7:107095146-107096593 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0030157
protein coding gene Chr7:106327914-106329354 (-)
CAST/EiJ MGP_CASTEiJ_G0031707
protein coding gene Chr7:98644272-98645719 (-)
CBA/J MGP_CBAJ_G0032344
protein coding gene Chr7:114929490-114930937 (-)
DBA/2J MGP_DBA2J_G0032498
protein coding gene Chr7:102555594-102557041 (-)
FVB/NJ MGP_FVBNJ_G0032451
protein coding gene Chr7:102274157-102281034 (-)
LP/J MGP_LPJ_G0032591
protein coding gene Chr7:108350148-108351621 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0031421
protein coding gene Chr7:95541940-95543488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031265
protein coding gene Chr7:93224324-93227290 (-)
WSB/EiJ MGP_WSBEiJ_G0031821
protein coding gene Chr7:106670682-106672129 (-)



Homology
more
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HBB, hemoglobin subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    beta-globin, CD113t-C, ECYT6
  • Links
    NCBI Gene ID: 3043
    neXtProt AC: NX_P68871
    UniProt: P68871

  • Chr Location
    11p15.4; chr11:5225466-5227071 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human HBB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hbb-bt
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 101488143 NCBI Gene Model | MGI Sequence Detail 1400 C57BL/6J ±  kb
transcript NM_008220 RefSeq | MGI Sequence Detail 646 C57BL/6  
polypeptide NP_032246 RefSeq | MGI Sequence Detail 147 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:32353 Weaver S, et al., The adult beta-globin genes of the single type mouse C57BL. Cell. 1981 May;24(2):403-11
  • Latest
    J:265272 Ghanem LR, et al., Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Mol Cell Biol. 2018 Aug 15;38(16)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory