Hbb-bt MGI Mouse Gene Detail - MGI:5474850 - hemoglobin, beta adult t chain

Symbol

Hbb-bt
Name

hemoglobin, beta adult t chain
Synonyms

beta t

Feature Type

protein coding gene
IDs

MGI:5474850
NCBI Gene: 101488143
Member of

Hbb cluster
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:103461731-103463130 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, Syntenic

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

9

Strain-Specific Marker

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5474850	protein coding gene	Chr7:103461731-103463203 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	ENSMUSG00215050917	protein coding gene	Chr7:91309052-91310524 (-)
C57BL/6NJ	ENSMUSG00215050924	protein coding gene	Chr7:91323071-91324633 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030157	protein coding gene	Chr7:106327914-106329354 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
JF1/MsJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	ENSMUSG00190034636	protein coding gene	Chr7:92228172-92229734 (-)
NOD/ShiLtJ	ENSMUSG00190034597	protein coding gene	Chr7:92214166-92215638 (-)
NZO/HlLtJ	ENSMUSG00225050651	protein coding gene	Chr7:100631021-100632583 (-)
NZO/HlLtJ	ENSMUSG00225050646	protein coding gene	Chr7:100617027-100618499 (-)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010034699	protein coding gene	Chr7:91687580-91689051 (-)
WSB/EiJ	no annotation

Human Ortholog

HBB, hemoglobin subunit beta

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HBB, hemoglobin subunit beta
Synonyms

beta-globin, CD113t-C, ECYT6
Links

HGNC:4827

NCBI Gene ID: 3043

UniProt: P68871
Chr Location

11p15.4; chr11:5225464-5229395 (-) GRCh38

Human Ortholog

HBD, hemoglobin subunit delta
Synonyms

HBK
Links

HGNC:4829

NCBI Gene ID: 3045

UniProt: P02042
Chr Location

11p15.4; chr11:5232678-5243657 (-) GRCh38

MGI Vertebrate Homology

Hbb-bt stringent orthology
2 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: HBB, HBD
Gene Tree

Hbb-bt

Diseases

14 with human HBB associations

Human Disease

Mouse Models

acute chest syndrome

IDs

alpha thalassemia

IDs

autosomal dominant beta thalassemia

IDs

beta thalassemia

IDs

View 17 models

congenital hemolytic anemia

IDs

delta beta-thalassemia

IDs

familial erythrocytosis 6

IDs

IDs

IDs

IDs

IDs

IDs

IDs

View 7 models

sickle cell disease

IDs

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Genomic Mutations

3 involving Hbb-bt
Find Mice (IMSR)

5 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

654
Tissues

8
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
CCDS

CCDS40060.1

Ensembl

ENSMUSG00000073940 (Evidence)
NCBI Gene

101488143

			Length	Strain/Species	Flank
genomic	101488143	NCBI Gene Model \| MGI Sequence Detail	1400	C57BL/6J	± kb
transcript	NM_008220	RefSeq \| MGI Sequence Detail	646	ZRU/MplStud
polypeptide	NP_032246	RefSeq \| MGI Sequence Detail	147	ZRU/MplStud

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All nucleic 22

cDNA 18

Primer pair 4

Summaries

All 28

Developmental Gene Expression 5

Phenotypes 14
Earliest

J:32353 Weaver S, et al., The adult beta-globin genes of the single type mouse C57BL. Cell. 1981 May;24(2):403-11
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hbb-bt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73964	Chr7:103463120-103463134 (-)	3 bp
Tssr73963	Chr7:103462948-103462962 (-)	175 bp
Tssr73962	Chr7:103461892-103461903 (-)	1,232 bp
Tssr73961	Chr7:103461861-103461881 (-)	1,259 bp
Tssr73960	Chr7:103461845-103461856 (-)	1,279 bp
Tssr73959	Chr7:103461831-103461840 (-)	1,294 bp
Tssr73958	Chr7:103461786-103461807 (-)	1,333 bp
Tssr73957	Chr7:103461756-103461779 (-)	1,362 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24