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Smad3
Gene Detail
Symbol

Name
ID
Smad3
SMAD family member 3
MGI:1201674
Synonyms
Madh3, Smad 3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
34.22 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:63646767-63757994 bp, - strand
From VEGA annotation of GRCm38

  111228 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55937  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Smad protein
Gene Tree: Smad3

Human
homologs
Human Homolog SMAD3, SMAD family member 3
NCBI Gene ID 4088
neXtProt AC  NX_P84022
Human Synonyms  HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
Human Chr (Location)  15q22.33; chr15:67065857-67195195 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMAD3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted mutations exhibit reduced mucosal immunity, chronic intestinal inflammation (sometimes with colonic adenocarcinoma), forelimb malformation, reduced mineralization of enamel, impaired growth of ovarian follicles, and develop osteoarthritis.
 
Human Diseases Modeled Using Mouse Smad3 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Smad3 interacts with 303 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (78 records)
Data Summary: Results (220)    Tissues (91)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 115
In situ reporter (knock in) 3
Northern blot 6
Western blot 28
RT-PCR 49
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(129) Genomic(4) cDNA(115) Primer pair(9) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021500 (Evidence)
Ensembl Gene ModelENSMUSG00000032402 (Evidence)
Entrez Gene17127 (Evidence)
UniGene7320
DFCITC1582138, TC1630900
DoTSDT.101354158, DT.101378988, DT.40177981, DT.97410937
NIA Mouse Gene IndexU030990
Consensus CDS ProjectCCDS23272.1
International Mouse Knockout Project StatusSmad3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021500 VEGA Gene Model | MGI Sequence Detail 111228 C57BL/6J ±  kb
transcript OTTMUST00000050960 VEGA | MGI Sequence Detail 5090 Not Applicable 
polypeptide OTTMUSP00000023917 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(8) UniProt(11)
Polymorphisms
SNPs within 2kb(517 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013790 Dwarfin
InterPro IPR003619 MAD homology 1, Dwarfin-type
InterPro IPR013019 MAD homology, MH1
InterPro IPR001132 SMAD domain, Dwarfin-type
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000000365 smad3
References
(Earliest) J:46375 Zhao J, et al., Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture. Dev Biol. 1998 Feb 15;194(2):182-95
(Latest) J:213791 Dutta DJ, et al., Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
All references(343)
Disease annotation references (1)
Other
accession IDs
MGI:2143216

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory