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Smad3 Gene Detail
Summary
  • Symbol
    Smad3
  • Name
    SMAD family member 3
  • Synonyms
    Madh3, Smad 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201674
    NCBI Gene: 17127
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:63646767-63757994 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.22 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201674
 protein coding gene Chr9:63646766-63757994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034932
 protein coding gene Chr9:63258061-63370076 (-)
A/J MGP_AJ_G0034912
 protein coding gene Chr9:61154391-61265338 (-)
AKR/J MGP_AKRJ_G0034842
 protein coding gene Chr9:62574622-62688282 (-)
BALB/cJ MGP_BALBcJ_G0034905
 protein coding gene Chr9:60881623-60992932 (-)
C3H/HeJ MGP_C3HHeJ_G0034615
 protein coding gene Chr9:63094511-63208380 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035424
 protein coding gene Chr9:64976951-65091751 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032335
 protein coding gene Chr9:60815017-60925455 (-)
CAST/EiJ MGP_CASTEiJ_G0033936
 protein coding gene Chr9:63247288-63362410 (-)
CBA/J MGP_CBAJ_G0034586
 protein coding gene Chr9:67222451-67343720 (-)
DBA/2J MGP_DBA2J_G0034745
 protein coding gene Chr9:60940190-61051598 (-)
FVB/NJ MGP_FVBNJ_G0034687
 protein coding gene Chr9:60240388-60352183 (-)
LP/J MGP_LPJ_G0034828
 protein coding gene Chr9:63547320-63661120 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034730
 protein coding gene Chr9:68546665-68665643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035446
 protein coding gene Chr9:62673276-62790985 (-)
PWK/PhJ MGP_PWKPhJ_G0033640
 protein coding gene Chr9:61085474-61200977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033474
 protein coding gene Chr9:62940961-63057940 (-)
WSB/EiJ MGP_WSBEiJ_G0034049
 protein coding gene Chr9:62570312-62686746 (-)



Homology
more
  • Human Ortholog
    SMAD3, SMAD family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMAD3, SMAD family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
  • Links
    NCBI Gene ID: 4088
    neXtProt AC: NX_P84022
    UniProt: P84022

  • Chr Location
    15q22.33; chr15:67065698-67195195 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Smad3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 5 alleles in 9 genetic backgrounds
    60 phenotypes from multigenic genotypes
    4 images
    192 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit reduced mucosal immunity, chronic intestinal inflammation (sometimes with colonic adenocarcinoma), forelimb malformation, reduced mineralization of enamel, impaired growth of ovarian follicles, and develop osteoarthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    174
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    296
  • Tissues
    147
  • cDNA Data
    115
  • Literature Summary
    127
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032402 Ensembl Gene Model | MGI Sequence Detail 111228 C57BL/6J ±  kb
    transcript ENSMUST00000034973 Ensembl | MGI Sequence Detail 5090 Not Applicable  
    polypeptide ENSMUSP00000034973 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 4
      cDNA 117
      Primer pair 9
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143216
    References
    more
    • Summaries
      All 476
      Developmental Gene Expression 127
      Diseases 3
      Gene Ontology 45
      Phenotypes 192
    • Earliest
      J:159277 Zhang Y, et al., Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996 Sep 12;383(6596):168-72
    • Latest
      J:268171 Ono H, et al., Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy. Sci Rep. 2018 Jul 12;8(1):10548
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory