62 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Amhr2tm3(cre)Bhr/Amhr2+ Smad2tm1Cxd/Smad2tm1.1Mwst Smad3tm1Par/Smad3tm1Zuk involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cumulus expansion	J:142827
	abnormal ovarian follicle morphology	J:142827
	decreased litter size	J:142827
	decreased oocyte number	J:142827
	decreased tertiary ovarian follicle number	J:142827
	increased atretic ovarian follicle number	J:142827
	increased circulating follicle stimulating hormone level	J:142827
	increased circulating luteinizing hormone level	J:142827
	premature ovarian failure	J:142827
	reduced female fertility	J:142827
Chrdtm1Emdr/Chrdtm1Emdr Smad3tm1Xfw/Smad3+ involves: 129/Sv * 129S1/Sv * 129X1/SvJ	normal embryo phenotype	J:161524
Chrdtm1Emdr/Chrdtm1Emdr Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * 129S1/Sv * 129X1/SvJ	normal embryo phenotype	J:161524
Il6sttm1Ern/Il6st+ Smad3tm1Par/Smad3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased adenoma incidence	J:100160
Inhatm1Bay/Inhatm1Bay Smad3tm1Par/Smad3+ involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6	increased adrenal gland tumor incidence	J:125349
	increased ovary tumor incidence	J:125349
Inhatm1Bay/Inhatm1Bay Smad3tm1Par/Smad3tm1Par involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6	abnormal ovarian folliculogenesis	J:125349
	increased ovary tumor incidence	J:125349
	increased Sertoli cell number	J:125349
Nogtm1Amc/Nog+ Smad3tm1Xfw/Smad3+ involves: 129/Sv * 129S1/Sv	abnormal embryonic tissue morphology	J:161524
Nogtm1Amc/Nog+ Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * 129S1/Sv	abnormal embryonic tissue morphology	J:161524
	holoprosencephaly	J:161524
Nogtm1Amc/Nogtm1Amc Smad3tm1Xfw/Smad3+ involves: 129/Sv * 129S1/Sv	abnormal anterior definitive endoderm morphology	J:161524
	abnormal embryonic tissue morphology	J:161524
	abnormal mesendoderm development	J:161524
	abnormal prechordal plate morphology	J:161524
	abnormal primitive streak formation	J:161524
	holoprosencephaly	J:161524
Nogtm1Amc/Nogtm1Amc Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * 129S1/Sv	abnormal embryonic tissue morphology	J:161524
	holoprosencephaly	J:161524
Rab25tm1Jrgo/Rab25tm1Jrgo Smad3tm1Par/Smad3+ 129-Rab25tm1Jrgo Smad3tm1Par	abnormal colon morphology	J:158733
	abnormal rectum morphology	J:158733
	colon polyps	J:158733
	increased colon adenocarcinoma incidence	J:158733
Smad2tm1.1Epb/Smad2tm1.1Epb Smad3tm1Cxd/Smad3tm1Cxd involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL	abnormal cell morphology	J:119642
	decreased apoptosis	J:119642
	premature death	J:119642
Smad2tm1.1Epb/Smad2tm1.1Epb Smad3tm1Cxd/Smad3tm1Cxd Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL	abnormal cell morphology	J:119642
	abnormal cell physiology	J:119642
	increased physiological sensitivity to xenobiotic	J:119642
	normal liver/biliary system phenotype	J:119642
Smad2tm1Cxd/Smad2+ Smad3tm1Cxd/Smad3+ involves: 129S6/SvEvTac * C57BL/6	abnormal Meckel's cartilage morphology	J:76396
Smad2tm1Cxd/Smad2+ Smad3tm1Cxd/Smad3+ involves: 129S6/SvEvTac * NIH Black Swiss	abnormal craniofacial morphology	J:70388, J:106308
	abnormal developmental patterning	J:106308
	abnormal endoderm development	J:106308
	abnormal foregut morphology	J:106308
	abnormal gastrulation	J:106308
	abnormal heart looping	J:106308
	abnormal hepatic cord morphology	J:70388
	abnormal hepatoblast migration	J:106308
	abnormal hepatocyte physiology	J:70388
	abnormal liver morphology	J:70388
	abnormal pericardial cavity morphology	J:106308
	abnormal somite development	J:106308
	cyclopia	J:106308
	decreased hepatocyte proliferation	J:70388
	delayed hepatic development	J:106308
	dilated liver sinusoidal space	J:70388
	embryonic growth retardation	J:106308
	embryonic lethality during organogenesis, incomplete penetrance	J:70388
	holoprosencephaly	J:106308
	increased erythrocyte cell number	J:70388
	increased fetal size	J:70388
	lethality throughout fetal growth and development, complete penetrance	J:106308
	liver hypoplasia	J:70388, J:106308
	small liver	J:70388
	small thyroid gland	J:106308
Smad2tm1Rob/Smad2tm2Rob Smad3tm1Xfw/Smad3+ Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1	abnormal heart development	J:84300
	absent foregut	J:84300
	fused somites	J:84300
	rostral body truncation	J:84300
Smad2tm3Rob/Smad2tm3Rob Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR	osteoarthritis	J:95374